RESUMO
Two new fatty acid glucosides, (3E,8Z)-8-carboxy-1-(O-beta-D-glucopyranosyl)-2,6-dihydroxytritriaconta-3,8-diene (1) and (8Z)-8-carboxy-1-(O-beta-D-glucopyranosyl)-3,4-epoxy-2,6-dihydroxytritriacont-8-ene (2), have been isolated from the root bark of Ochna calodendron and their structures elucidated by extensive two-dimensional NMR methods including HMQC, HMBC and NOESY experiments.
Assuntos
Ácidos Graxos Insaturados/química , Ácidos Graxos/química , Glucosídeos/química , Magnoliopsida , Fitoterapia , Extratos Vegetais/química , Humanos , Raízes de PlantasRESUMO
Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
Assuntos
Boswellia/química , Glicosídeos/isolamento & purificação , Plantas Medicinais/química , Estilbenos/isolamento & purificação , Triterpenos/isolamento & purificação , Camarões , Inibidores Enzimáticos/química , Inibidores Enzimáticos/isolamento & purificação , Inibidores Enzimáticos/farmacologia , Glicosídeos/química , Glicosídeos/farmacologia , Concentração Inibidora 50 , Estrutura Molecular , Estilbenos/química , Estilbenos/farmacologia , Triterpenos/química , Triterpenos/farmacologiaRESUMO
Suitable drugs for the elimination of adult Onchocerca volvulus are still needed since ivermectin, the new microfilaricide, appears to be ineffective against this parasite stage. Herein we report on the identification of filaricides in three medicinal plants. The compounds carapolide A, mexicanolide-methylangolensate mixture from Carapa procera and oliverine from Polyalthia suaveolens or Pachypodanthium staudtii when tested at 10-100 micrograms.ml-1 were found to exhibit considerable microfilaricidal activity after 24 hours of incubation. Oliverine was found to be filaricidal when tested against adult female worms at 100 micrograms.ml-1. Preliminary toxicity studies in mice showed carapolide A and the mexicanolide-methylangolensate mixture to be relatively non-toxic, whereas, oliverine had a minimal lethal dose of 8 mg.Kg-1 of body weight. Based on the above results further pharmacologic studies are recommended to determine, the potential application of the active compounds on the treatment of onchocerciasis.