Detalhe da pesquisa
1.
Engineering CAR-T cells to activate small-molecule drugs in situ.
Nat Chem Biol
; 18(2): 216-225, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34969970
2.
Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics.
Antimicrob Agents Chemother
; 67(2): e0137722, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36715507
3.
Rational approaches for the design of various GABA modulators and their clinical progression.
Mol Divers
; 25(1): 551-601, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170466
4.
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.
Bioorg Med Chem
; 27(16): 3477-3510, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31255497
5.
Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor ß/δ agonists with neuroprotective activity.
Bioorg Med Chem Lett
; 26(8): 1889-93, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988304
6.
Tailored Quinolines Demonstrate Flexibility to Exert Antitumor Effects through Varied Mechanisms-A Medicinal Perspective.
Anticancer Agents Med Chem
; 21(3): 288-315, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32900354
7.
Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability.
J Med Chem
; 64(17): 12705-12722, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34436882
8.
Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes.
Methods Enzymol
; 638: 69-87, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32416922
9.
An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening.
ACS Pharmacol Transl Sci
; 3(5): 931-947, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073192
10.
Exogenous Flupirtine as Potential Treatment for CLN3 Disease.
Cells
; 9(8)2020 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32796515
11.
Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship.
Anticancer Agents Med Chem
; 19(7): 842-874, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30657048
12.
Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses.
Ann Clin Transl Neurol
; 5(9): 1089-1103, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30250865
13.
Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis.
ACS Chem Neurosci
; 8(1): 82-88, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27718545
14.
Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2).
J Med Chem
; 60(23): 9739-9756, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29110485
15.
Synthesis and Antineoplastic Evaluation of Mitochondrial Complexâ II (Succinate Dehydrogenase) Inhibitors Derived from Atpeninâ A5.
ChemMedChem
; 12(13): 1033-1044, 2017 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523727
16.
Correction to "Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability".
J Med Chem
; 65(1): 890, 2022 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935384
17.
Progress in the Development of Small Molecule Therapeutics for the Treatment of Neuronal Ceroid Lipofuscinoses (NCLs).
J Med Chem
; 59(10): 4415-27, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26565590