Detalhe da pesquisa
1.
Compound Activity Prediction with Dose-Dependent Transcriptomic Profiles and Deep Learning.
J Chem Inf Model
; 64(7): 2695-2704, 2024 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293736
2.
Dark chemical matter as a promising starting point for drug lead discovery.
Nat Chem Biol
; 11(12): 958-66, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26479441
3.
Drug target prediction through deep learning functional representation of gene signatures.
Nat Commun
; 15(1): 1853, 2024 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38424040
4.
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterâCompounds with Novel Mechanisms from High-Throughput Screening Profiles.
ACS Chem Biol
; 19(4): 938-952, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38565185
5.
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors.
Cell Rep
; 42(4): 112297, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961816
6.
Chemical and biological properties of frequent screening hits.
J Chem Inf Model
; 52(4): 913-26, 2012 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22435989
7.
EndoBind detects endogenous protein-protein interactions in real time.
Commun Biol
; 4(1): 1085, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34526658
8.
Chemical-text hybrid search engines.
J Chem Inf Model
; 50(1): 47-54, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047295
9.
Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma.
Clin Cancer Res
; 23(11): 2856-2868, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986745
10.
Profiling the kinome for drug discovery.
Drug Discov Today Technol
; 3(3): 269-76, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980528
11.
Seeing the light: luminescent reporter gene assays.
Comb Chem High Throughput Screen
; 14(8): 648-57, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21564017
12.
Multiplexed reporter gene assays: monitoring the cell viability and the compound kinetics on luciferase activity.
J Biomol Screen
; 16(7): 786-93, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21693766
13.
Large-scale annotation of small-molecule libraries using public databases.
J Chem Inf Model
; 47(4): 1386-94, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608408
14.
Learning from the data: mining of large high-throughput screening databases.
J Chem Inf Model
; 46(6): 2381-95, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125181
15.
An efficient rapid system for profiling the cellular activities of molecular libraries.
Proc Natl Acad Sci U S A
; 103(9): 3153-8, 2006 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492761
16.
Genome-scale functional profiling of the mammalian AP-1 signaling pathway.
Proc Natl Acad Sci U S A
; 100(21): 12153-8, 2003 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-14514886