Detalhe da pesquisa
1.
Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes.
Drug Metab Dispos
; 50(5): 566-575, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35246464
2.
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.
Drug Metab Dispos
; 48(10): 849-860, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32739889
3.
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
J Pharmacol Exp Ther
; 365(2): 237-248, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453199
4.
Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes.
AAPS J
; 22(6): 142, 2020 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33156404
5.
In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes.
AAPS J
; 22(6): 131, 2020 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051808
6.
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
AAPS J
; 19(2): 534-550, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28050713