Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia.

Nasri, Masoud; Ritter, Malte U; Mir, Perihan; Dannenmann, Benjamin; Kaufmann, Masako M; Arreba-Tutusaus, Patricia; Xu, Yun; Borbaran-Bravo, Natalia; Klimiankou, Maksim; Lengerke, Claudia; Zeidler, Cornelia; Cathomen, Toni; Welte, Karl; Skokowa, Julia.

Mol Ther ; 2024 Mar 30.

Artigo em Inglês | MEDLINE | ID: mdl-38556793

2.

HAX1-related congenital neutropenia: Long-term observation in paediatric and adult patients enrolled in the European branch of the Severe Chronic Neutropenia International Registry (SCNIR).

Pogozhykh, Denys; Yilmaz Karapinar, Deniz; Klimiankou, Maksim; Gerschmann, Natali; Ebetsberger-Dachs, Georg; Palmblad, Jan; Carlsson, Göran; Masmas, Tania; Kinsey, Sally; Bartels, Marije; Mellor-Heineke, Sabine; Welte, Karl; Skokowa, Julia; Zeidler, Cornelia.

Br J Haematol ; 202(2): 393-411, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37193639

3.

Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring ELANE mutations.

Zeidler, Alexander; Borbaran-Bravo, Natalia; Dannenmann, Benjamin; Ritter, Malte; Nasri, Masoud; Klimiankou, Maksim; Kandabarau, Sergey; Zahabi, Azadeh; König, Josef; Zeidler, Cornelia; Skokowa, Julia; Welte, Karl.

Haematologica ; 2023 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-37855057

4.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Morishima, Tatsuya; Krahl, Ann-Christin; Nasri, Masoud; Xu, Yun; Aghaallaei, Narges; Findik, Betül; Klimiankou, Maksim; Ritter, Malte; Hartmann, Marcus D; Gloeckner, Christian Johannes; Stefanczyk, Sylwia; Lindner, Christian; Oswald, Benedikt; Bernhard, Regine; Hähnel, Karin; Hermanutz-Klein, Ursula; Ebinger, Martin; Handgretinger, Rupert; Casadei, Nicolas; Welte, Karl; Andre, Maya; Müller, Patrick; Bajoghli, Baubak; Skokowa, Julia.

Blood ; 134(14): 1159-1175, 2019 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-31366618

5.

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.

Nasri, Masoud; Ritter, Malte; Mir, Perihan; Dannenmann, Benjamin; Aghaallaei, Narges; Amend, Diana; Makaryan, Vahagn; Xu, Yun; Fletcher, Breanna; Bernhard, Regine; Steiert, Ingeborg; Hahnel, Karin; Berger, Jürgen; Koch, Iris; Sailer, Brigitte; Hipp, Katharina; Zeidler, Cornelia; Klimiankou, Maksim; Bajoghli, Baubak; Dale, David C; Welte, Karl; Skokowa, Julia.

Haematologica ; 105(3): 598-609, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31248972

6.

Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs.

Ritter, Malte; Klimiankou, Maksim; Klimenkova, Olga; Schambach, Axel; Hoffmann, Dirk; Schmidt, Amy; Kanz, Lothar; Link, Daniel C; Welte, Karl; Skokowa, Julia.

Ann Hematol ; 99(10): 2329-2338, 2020 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-32821971

7.

Old drug revisited: disulfiram, NETs, and sepsis.

Klimiankou, Maksim; Skokowa, Julia.

Blood ; 138(25): 2604-2605, 2021 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-34940816

8.

Identification of GFI1 mutations in adult patients with congenital neutropenia.

Boutakoglou, Erasmia; Klimiankou, Maksim; Tsaknakis, Grigorios; Drakos, Elias; Skokowa, Julia; Papadaki, Helen A.

Ann Hematol ; 101(12): 2771-2773, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36112213

9.

Chronic neutropenic colitis with complete colonic obstruction in a patient with severe congenital neutropenia associated with G6PC3 mutations.

Nikolouzakis, Taxiarchis Konstantinos; Spyridakis, Konstantinos; Tzardi, Maria; Tsaknakis, Grigorios; Ximeri, Maria; Klimiankou, Maksim; Chrysos, Emmanuel; Skokowa, Julia; Papadaki, Helen A.

Ann Hematol ; 101(7): 1583-1585, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35084551

10.

ELANE mutant-specific activation of different UPR pathways in congenital neutropenia.

Nustede, Rainer; Klimiankou, Maksim; Klimenkova, Olga; Kuznetsova, Inna; Zeidler, Cornelia; Welte, Karl; Skokowa, Julia.

Br J Haematol ; 172(2): 219-27, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26567890

11.

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.

Klimenkova, Olga; Ellerbeck, Wienke; Klimiankou, Maksim; Ünalan, Murat; Kandabarau, Siarhei; Gigina, Anna; Hussein, Kais; Zeidler, Cornelia; Welte, Karl; Skokowa, Julia.

Blood ; 123(8): 1239-49, 2014 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-24352879

12.

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.

Gupta, Kshama; Kuznetsova, Inna; Klimenkova, Olga; Klimiankou, Maksim; Meyer, Johann; Moore, Malcolm A S; Zeidler, Cornelia; Welte, Karl; Skokowa, Julia.

Blood ; 123(16): 2550-61, 2014 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-24394665

13.

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.

Skokowa, Julia; Steinemann, Doris; Katsman-Kuipers, Jenny E; Zeidler, Cornelia; Klimenkova, Olga; Klimiankou, Maksim; Unalan, Murat; Kandabarau, Siarhei; Makaryan, Vahagn; Beekman, Renee; Behrens, Kira; Stocking, Carol; Obenauer, Julia; Schnittger, Susanne; Kohlmann, Alexander; Valkhof, Marijke G; Hoogenboezem, Remco; Göhring, Gudrun; Reinhardt, Dirk; Schlegelberger, Brigitte; Stanulla, Martin; Vandenberghe, Peter; Donadieu, Jean; Zwaan, C Michel; Touw, Ivo P; van den Heuvel-Eibrink, Marry M; Dale, David C; Welte, Karl.

Blood ; 123(14): 2229-37, 2014 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-24523240

14.

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML.

Klimiankou, Maksim; Mellor-Heineke, Sabine; Klimenkova, Olga; Reinel, Elisa; Uenalan, Murat; Kandabarau, Siarhei; Skokowa, Julia; Welte, Karl; Zeidler, Cornelia.

Blood ; 127(21): 2638-41, 2016 05 26.

Artigo em Inglês | MEDLINE | ID: mdl-27030388

15.

GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations.

Klimiankou, Maksim; Klimenkova, Olga; Uenalan, Murat; Zeidler, Alexander; Mellor-Heineke, Sabine; Kandabarau, Siarhei; Skokowa, Julia; Zeidler, Cornelia; Welte, Karl.

Blood ; 126(15): 1865-7, 2015 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-26324699

16.

Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche.

Borbaran-Bravo, Natalia; Arreba-Tutusaus, Patricia; Ritter, Malte U; Nasri, Masoud; Klimiankou, Maksim; Skokowa, Julia.

Cell Rep Med ; 3(8): 100724, 2022 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-35977470

17.

iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.

Dannenmann, Benjamin; Klimiankou, Maksim; Oswald, Benedikt; Solovyeva, Anna; Mardan, Jehan; Nasri, Masoud; Ritter, Malte; Zahabi, Azadeh; Arreba-Tutusaus, Patricia; Mir, Perihan; Stein, Frederic; Kandabarau, Siarhei; Lachmann, Nico; Moritz, Thomas; Morishima, Tatsuya; Konantz, Martina; Lengerke, Claudia; Ripperger, Tim; Steinemann, Doris; Erlacher, Miriam; Niemeyer, Charlotte M; Zeidler, Cornelia; Welte, Karl; Skokowa, Julia.

Cell Stem Cell ; 28(5): 906-922.e6, 2021 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-33894142

18.

Gene Knockout in Hematopoietic Stem and Progenitor Cells Followed by Granulocytic Differentiation.

Mir, Perihan; Ritter, Malte; Welte, Karl; Skokowa, Julia; Klimiankou, Maksim.

Methods Mol Biol ; 2115: 455-469, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32006417

19.

New insights into the pathomechanism of cyclic neutropenia.

Mir, Perihan; Klimiankou, Maksim; Findik, Betuel; Hähnel, Karin; Mellor-Heineke, Sabine; Zeidler, Cornelia; Skokowa, Julia; Welte, Karl.

Ann N Y Acad Sci ; 1466(1): 83-92, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32083314

20.

Ultra-Sensitive CSF3R Deep Sequencing in Patients With Severe Congenital Neutropenia.

Klimiankou, Maksim; Uenalan, Murat; Kandabarau, Siarhei; Nustede, Rainer; Steiert, Ingeborg; Mellor-Heineke, Sabine; Zeidler, Cornelia; Skokowa, Julia; Welte, Karl.

Front Immunol ; 10: 116, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30891028

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