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1.
Phys Rev Lett ; 122(7): 077202, 2019 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-30848651

RESUMO

Yb(Rh_{1-x}Co_{x})_{2}Si_{2} is a model system to address two challenging problems in the field of strongly correlated electron systems. The first is the intriguing competition between ferromagnetic (FM) and antiferromagnetic (AFM) order when approaching a magnetic quantum critical point (QCP). The second is the occurrence of magnetic order along a very hard crystalline electric field (CEF) direction, i.e., along the one with the smallest available magnetic moment. Here, we present a detailed study of the evolution of the magnetic order in this system from a FM state with moments along the very hard c direction at x=0.27 towards the yet unknown magnetic state at x=0. We first observe a transition towards an AFM canted state with decreasing x and then to a pure AFM state. This confirms that the QCP in YbRh_{2}Si_{2} is AFM, but the phase diagram is very similar to those observed in some inherently FM systems like NbFe_{2} and CeRuPO, which suggests that the basic underlying instability might be FM. Despite the huge CEF anisotropy the ordered moment retains a component along the c axis also in the AFM state. The huge CEF anisotropy in Yb(Rh_{1-x}Co_{x})_{2}Si_{2} excludes that this hard-axis ordering originates from a competing exchange anisotropy as often proposed for other heavy-fermion systems. Instead, it points to an order-by-disorder based mechanism.

2.
Psychol Res ; 82(1): 177-185, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29196834

RESUMO

Dual tasking, or the simultaneous execution of two continuous tasks, is frequently associated with a performance decline that can be explained within a capacity sharing framework. In this study, we assessed the effects of a concurrent motor task on the efficiency of visual information uptake based on the 'theory of visual attention' (TVA). TVA provides parameter estimates reflecting distinct components of visual processing capacity: perceptual threshold, visual processing speed, and visual short-term memory (VSTM) storage capacity. Moreover, goodness-of-fit values and bootstrapping estimates were derived to test whether the TVA-model is validly applicable also under dual task conditions, and whether the robustness of parameter estimates is comparable in single- and dual-task conditions. 24 subjects of middle to higher age performed a continuous tapping task, and a visual processing task (whole report of briefly presented letter arrays) under both single- and dual-task conditions. Results suggest a decline of both visual processing capacity and VSTM storage capacity under dual-task conditions, while the perceptual threshold remained unaffected by a concurrent motor task. In addition, goodness-of-fit values and bootstrapping estimates support the notion that participants processed the visual task in a qualitatively comparable, although quantitatively less efficient way under dual-task conditions. The results support a capacity sharing account of motor-cognitive dual tasking and suggest that even performing a relatively simple motor task relies on central attentional capacity that is necessary for efficient visual information uptake.


Assuntos
Comportamento de Escolha/fisiologia , Cognição/fisiologia , Memória de Curto Prazo/fisiologia , Comportamento Multitarefa/fisiologia , Desempenho Psicomotor/fisiologia , Análise e Desempenho de Tarefas , Percepção Visual/fisiologia , Adulto , Idoso , Tomada de Decisões/fisiologia , Feminino , Alemanha , Humanos , Masculino , Pessoa de Meia-Idade
3.
Exp Biol Med (Maywood) ; 249: 10037, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38854792

RESUMO

In-ovo imaging using avian eggs has been described as a potential alternative to animal testing using rodents. However, imaging studies are hampered by embryonal motion producing artifacts. This study aims at systematically comparing isoflurane, desflurane and sevoflurane in three different concentrations in ostrich embryos. Biomagnetic signals of ostrich embryos were recorded analyzing cardiac action and motion. Ten groups comprising eight ostrich embryos each were investigated: Control, isoflurane (2%, 4%, and 6%), desflurane (6%, 12%, and 18%) and sevoflurane (3%, 5%, and 8%). Each ostrich egg was exposed to the same narcotic gas and concentration on development day (DD) 31 and 34. Narcotic gas exposure was upheld for 90 min and embryos were monitored for additional 75 min. Toxicity was evaluated by verifying embryo viability 24 h after the experiments. Initial heart rate of mean 148 beats/min (DD 31) and 136 beats/min (DD 34) decreased over time by 44-48 beats/minute. No significant differences were observed between groups. All narcotic gases led to distinct movement reduction after mean 8 min. Embryos exposed to desflurane 6% showed residual movements. Isoflurane 6% and sevoflurane 8% produced motion-free time intervals of mean 70 min after discontinuation of narcotic gas exposure. Only one embryo death occurred after narcotic gas exposure with desflurane 6%. This study shows that isoflurane, desflurane and sevoflurane are suitable for ostrich embryo immobilization, which is a prerequisite for motion-artifact free imaging. Application of isoflurane 6% and sevoflurane 8% is a) safe as no embryonal deaths occurred after exposure and b) effective as immobilization was observed for approx. 70 min after the end of narcotic gas exposure. These results should be interpreted with caution regarding transferability to other avian species as differences in embryo size and incubation duration exist.


Assuntos
Desflurano , Embrião não Mamífero , Isoflurano , Struthioniformes , Animais , Struthioniformes/embriologia , Embrião não Mamífero/efeitos dos fármacos , Anestésicos Inalatórios , Sevoflurano/efeitos adversos , Sevoflurano/farmacologia , Entorpecentes/toxicidade , Imobilização
4.
Phys Rev Lett ; 110(25): 256402, 2013 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-23829749

RESUMO

YbRh2Si2 is a prototypical system for studying unconventional antiferromagnetic quantum criticality. However, ferromagnetic correlations are present which can be enhanced via isoelectronic cobalt substitution for rhodium in Yb(Rh(1-x)Co(x))2Si2. So far, the magnetic order with increasing x was believed to remain antiferromagnetic. Here, we present the discovery of ferromagnetism for x = 0.27 below T(C) = 1.30 K in single crystalline samples. Unexpectedly, ordering occurs along the c axis, the hard crystalline electric field direction, where the g factor is an order of magnitude smaller than in the basal plane. Although the spontaneous magnetization is only 0.1 µB/Yb it corresponds to the full expected saturation moment along c taking into account partial Kondo screening.

5.
HNO ; 58(5): 433-42, 2010 May.
Artigo em Alemão | MEDLINE | ID: mdl-20424810

RESUMO

Modern imaging techniques used for depicting the facial nerve include multi-slice spiral computed tomography (CT) and high-field magnetic resonance imaging (MRI). CT is the gold standard for imaging the osseous structures of the temporal bone. As a result of its excellent soft tissue contrast, MRI enables identification of the facial nerve itself. Due to high spatial resolution and the possibility to generate multiplanar reconstructions, both CT and MRI facilitate an exact evaluation of anatomical structures in all three spatial planes. The present article provides an overview of relevant anatomical structures, a thorough knowledge of which is the basic prerequisite to understanding pathologies and interpreting radiological findings correctly. Furthermore, basic techniques and strategies for imaging the facial nerve using CT and MRI are explained in general. The articles concludes with specific requirements for the radiological diagnosis of dysplasia, neoplasms and trauma, as well as vascular and inflammatory diseases.


Assuntos
Doenças do Nervo Facial/diagnóstico , Nervo Facial/diagnóstico por imagem , Nervo Facial/patologia , Imageamento por Ressonância Magnética/métodos , Tomografia Computadorizada por Raios X/métodos , Humanos
7.
J Laryngol Otol ; 129(4): e1, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25776098

RESUMO

BACKGROUND: Neuralgic amyotrophy is a polyneuropathy that classically involves the brachial plexus. This paper reports an unusual clinical manifestation associated with vocal fold paralysis. CASE REPORT: A 36-year-old male presented with hoarseness and progressive weakness of the right shoulder and upper arm muscles. Laryngoscopy revealed a limited adduction of the right vocal fold. RESULTS: Subsequent speech therapy did not improve the symptoms. Therefore, vocal fold augmentation by application of hyaluronic acid in the right vocal fold was performed. CONCLUSION: Vocal fold augmentation with resorbable material seems to be a more effective transient treatment than speech therapy alone for patients with neuralgic amyotrophy and laryngeal involvement.


Assuntos
Neurite do Plexo Braquial/complicações , Ácido Hialurônico/uso terapêutico , Viscossuplementos/uso terapêutico , Paralisia das Pregas Vocais/etiologia , Paralisia das Pregas Vocais/terapia , Prega Vocal , Adulto , Humanos , Masculino
8.
J Phys Condens Matter ; 24(29): 294201, 2012 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-22773300

RESUMO

Both CeCu2Si2 and YbRh2Si2 crystallize in the tetragonal ThCr2Si2 crystal structure. Recent neutron-scattering results on normal-state CeCu2Si2 reveal a slowing down of the quasielastic response which complies with the scaling expected for a quantum critical point (QCP) of itinerant, i.e., three-dimensional spin-density-wave (SDW), type. This interpretation is in full agreement with the non-Fermi-liquid behavior observed in transport and thermodynamic measurements. The momentum dependence of the magnetic excitation spectrum reveals two branches of an overdamped dispersive mode whose coupling to the heavy charge carriers is strongly retarded. These overdamped spin fluctuations are considered to be the driving force for superconductivity in CeCu2Si2 (Tc = 600 mK). The weak antiferromagnet YbRh2Si2 (TN = 70 mK) exhibits a magnetic-field-induced QCP at BN = 0.06 T (B⊥c). There is no indication of superconductivity down to T = 10 mK. The magnetic QCP appears to concur with a breakdown of the Kondo effect. Doping-induced variations of the average unit-cell volume result in a detachment of the magnetic and electronic instabilities. A comparison of the properties of these isostructural compounds suggests that 3D SDW QCPs are favorable for unconventional superconductivity. The question whether a Kondo-breakdown QCP may also give rise to superconductivity, however, remains to be clarified.


Assuntos
Elétrons , Fenômenos Magnéticos , Metais/química , Teoria Quântica , Temperatura
9.
Neuroradiology ; 46(5): 363-7, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15045495

RESUMO

Previous studies have shown that valproate is detectable in vitro by 1H magnetic resonance spectroscopy (MRS) at 1.5 T, whereas in patients on valproate monotherapy, no significant dose-dependent valproate signal could be seen. To investigate whether an increased signal-to-noise ratio as provided by higher valproate doses and increased magnetic field strength would enable detection of valproate in vivo, six Wistar rats were examined using volume-selective 1H MRS at 2.34 T. The spectra were analyzed by fitting a linear superposition of the basis spectra of valproate, brain metabolites, and simulated lipid signals. The analysis revealed no significant signal contributions after valproate administration of up to 330 mg/kg body weight. To analyze how underlying mechanisms, such as potential drug interactions with macromolecules, may affect the valproate signal, additional in vitro spectra of valproate were measured before and after adding albumin. The spectra exhibited a strong decrease of the valproate signal with increasing albumin concentration. The results support the hypothesis that in vivo valproate is bound to a high degree to macromolecules and will therefore not be detectable by 1H MRS.


Assuntos
Anticonvulsivantes/farmacocinética , Encéfalo/metabolismo , Ácido Valproico/farmacocinética , Animais , Anticonvulsivantes/administração & dosagem , Relação Dose-Resposta a Droga , Metabolismo dos Lipídeos , Espectroscopia de Ressonância Magnética , Ratos , Ratos Wistar , Soroalbumina Bovina/metabolismo , Ácido Valproico/administração & dosagem
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