Detalhe da pesquisa
1.
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Nature
; 605(7908): 146-151, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314834
2.
Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.
PLoS Pathog
; 19(8): e1011328, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549173
3.
The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae.
Infect Immun
; 92(5): e0052223, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629842
4.
Oxadiazepinone HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 52: 128353, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492302
5.
Identification of a new class of HBV capsid assembly modulator.
Bioorg Med Chem Lett
; 39: 127848, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33610748
6.
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Gastroenterology
; 156(5): 1392-1403.e7, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30625297
7.
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection.
J Hepatol
; 71(6): 1086-1098, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31349000
8.
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373799
9.
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
Gastroenterology
; 154(3): 652-662.e8, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079518
10.
SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 29(16): 2405-2409, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31227344
11.
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Proc Natl Acad Sci U S A
; 112(49): 15196-201, 2015 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26598693
12.
Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559265
13.
Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody.
Hepatology
; 61(4): 1136-44, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25417967
14.
A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylation.
Mol Cell Proteomics
; 13(11): 3040-8, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044019
15.
NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Proc Natl Acad Sci U S A
; 110(5): E348-57, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307808
16.
Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.
Gastroenterology
; 146(1): 63-6.e5, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24076507
17.
Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.
J Virol
; 88(9): 4647-56, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24478422
18.
Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage.
Nucleic Acids Res
; 41(17): 8289-99, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23847103
19.
In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir.
J Infect Dis
; 209(5): 668-75, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24154738
20.
Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration.
J Hepatol
; 60(3): 500-7, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398036