Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

CONCERTO: A randomized, placebo-controlled trial of oral laquinimod in relapsing-remitting multiple sclerosis.

Comi, Giancarlo; Dadon, Yuval; Sasson, Nissim; Steinerman, Joshua R; Knappertz, Volker; Vollmer, Timothy L; Boyko, Alexey; Vermersch, Patrick; Ziemssen, Tjalf; Montalban, Xavier; Lublin, Fred D; Rocca, Maria A; Volkinshtein, Rita; Rubinchick, Svetlana; Halevy, Nitsan; Filippi, Massimo.

Mult Scler ; 28(4): 608-619, 2022 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-34378456

2.

Time to onset of cannabidiol (CBD) treatment effect in Lennox-Gastaut syndrome: Analysis from two randomized controlled trials.

Privitera, Michael; Bhathal, Hari; Wong, Matthew; Cross, J Helen; Wirrell, Elaine; Marsh, Eric D; Mazurkiewicz-Beldzinska, Maria; Villanueva, Vicente; Checketts, Daniel; Knappertz, Volker; VanLandingham, Kevan.

Epilepsia ; 62(5): 1130-1140, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33797076

3.

Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials.

Devinsky, Orrin; Thiele, Elizabeth A; Wright, Stephen; Checketts, Daniel; Morrison, Gilmour; Dunayevich, Eduardo; Knappertz, Volker.

Acta Neurol Scand ; 142(6): 531-540, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-32592183

4.

Validating the use of brain volume cutoffs to identify clinically relevant atrophy in RRMS.

Bovis, Francesca; De Stefano, Nicola; Steinerman, Joshua R; Knappertz, Volker; Sormani, Maria Pia.

Mult Scler ; 25(2): 217-223, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-29154721

5.

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor.

Kaye, Joel; Piryatinsky, Victor; Birnberg, Tal; Hingaly, Tal; Raymond, Emanuel; Kashi, Rina; Amit-Romach, Einat; Caballero, Ignacio S; Towfic, Fadi; Ator, Mark A; Rubinstein, Efrat; Laifenfeld, Daphna; Orbach, Aric; Shinar, Doron; Marantz, Yael; Grossman, Iris; Knappertz, Volker; Hayden, Michael R; Laufer, Ralph.

Proc Natl Acad Sci U S A ; 113(41): E6145-E6152, 2016 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-27671624

6.

Laquinimod efficacy in relapsing-remitting multiple sclerosis: how to understand why and if studies disagree.

Cutter, Gary R; Knappertz, Volker; Sasson, Nissim; Ladkani, David.

BMC Neurol ; 16: 176, 2016 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-27639853

7.

CD19 as a molecular target in CNS autoimmunity.

Stüve, Olaf; Warnke, Clemens; Deason, Krystin; Stangel, Martin; Kieseier, Bernd C; Hartung, Hans-Peter; von Büdingen, Hans-Christian; Centonze, Diego; Forsthuber, Thomas G; Knappertz, Volker.

Acta Neuropathol ; 128(2): 177-90, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24993505

8.

Pharmacodynamic synergism contributes to the antiseizure action of cannabidiol and clobazam.

Rana, Rohini R; Rajasekaran, Karthik; Knappertz, Volker; Gray, Royston A.

Exp Neurol ; 360: 114286, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36442674

9.

Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon ß-1b trial in multiple sclerosis.

Goodin, Douglas S; Traboulsee, Anthony; Knappertz, Volker; Reder, Anthony T; Li, David; Langdon, Dawn; Wolf, Christian; Beckmann, Karola; Konieczny, Andreas; Ebers, George C.

J Neurol Neurosurg Psychiatry ; 83(3): 282-7, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22193561

10.

Neutralizing antibodies to interferon beta-1b multiple sclerosis: a clinico-radiographic paradox in the BEYOND trial.

Goodin, Douglas S; Hartung, Hans-Peter; O'Connor, Paul; Filippi, Massimo; Arnason, Barry; Comi, Giancarlo; Cook, Stuart; Jeffery, Douglas; Kappos, Ludwig; Bogumil, Timon; Knappertz, Volker; Sandbrink, Rupert; Beckmann, Karola; White, Rick; Petkau, John; Pohl, Christoph.

Mult Scler ; 18(2): 181-95, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21952094

11.

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial.

Watkins, Paul B; Church, Rachel J; Li, Jie; Knappertz, Volker.

Clin Pharmacol Ther ; 109(5): 1224-1231, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33022751

12.

Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial.

Thiele, Elizabeth A; Bebin, E Martina; Bhathal, Hari; Jansen, Floor E; Kotulska, Katarzyna; Lawson, John A; O'Callaghan, Finbar J; Wong, Michael; Sahebkar, Farhad; Checketts, Daniel; Knappertz, Volker.

JAMA Neurol ; 78(3): 285-292, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33346789

13.

Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial.

Miller, Ian; Scheffer, Ingrid E; Gunning, Boudewijn; Sanchez-Carpintero, Rocio; Gil-Nagel, Antonio; Perry, M Scott; Saneto, Russell P; Checketts, Daniel; Dunayevich, Eduardo; Knappertz, Volker.

JAMA Neurol ; 77(5): 613-621, 2020 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-32119035

14.

A randomized, placebo-controlled, phase 2 trial of laquinimod in primary progressive multiple sclerosis.

Giovannoni, Gavin; Knappertz, Volker; Steinerman, Joshua R; Tansy, Aaron P; Li, Thomas; Krieger, Stephen; Uccelli, Antonio; Uitdehaag, Bernard M J; Montalban, Xavier; Hartung, Hans-Peter; Pia Sormani, Maria; Cree, Bruce A C; Lublin, Fred; Barkhof, Frederik.

Neurology ; 95(8): e1027-e1040, 2020 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-32651286

15.

Sample size estimates for clinical trials of vasospasm in subarachnoid hemorrhage.

Kreiter, Kurt T; Mayer, Stephan A; Howard, George; Knappertz, Volker; Ilodigwe, Don; Sloan, Michael A; Macdonald, R Loch.

Stroke ; 40(7): 2362-7, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19461029

16.

Needles: a comparison study.

Mayer, Gerhard; Knappertz, Volker; Kinast, Peter.

Med Device Technol ; 20(7): 30, 32-4, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-20058653

17.

An assessment of the joint associations of aspirin and statin use with C-reactive protein concentration.

Fisher, Matt; Cushman, Mary; Knappertz, Volker; Howard, George.

Am Heart J ; 156(1): 106-11, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18585504

18.

Time course of glatiramer acetate efficacy in patients with RRMS in the GALA study.

Davis, Mat D; Ashtamker, Natalia; Steinerman, Joshua R; Knappertz, Volker.

Neurol Neuroimmunol Neuroinflamm ; 4(2): e327, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-28210662

19.

Long-term safety and tolerability of glatiramer acetate 20 mg/ml in the treatment of relapsing forms of multiple sclerosis.

Ziemssen, Tjalf; Ashtamker, Natalia; Rubinchick, Svetlana; Knappertz, Volker; Comi, Giancarlo.

Expert Opin Drug Saf ; 16(2): 247-255, 2017 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-27989217

20.

Once-daily glatiramer acetate decreases magnetic resonance imaging disease activity in Japanese patients with relapsing-remitting multiple sclerosis.

Yamamura, Takashi; Ashtamker, Natalia; Ladkani, David; Fukazawa, Toshiyuki; Houzen, Hideki; Tanaka, Masami; Miura, Toshiro; Knappertz, Volker.

Clin Exp Neuroimmunol ; 8(2): 129-137, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28706565

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