Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.

Di Pilato, Mauro; Kfuri-Rubens, Raphael; Pruessmann, Jasper N; Ozga, Aleksandra J; Messemaker, Marius; Cadilha, Bruno L; Sivakumar, Ramya; Cianciaruso, Chiara; Warner, Ross D; Marangoni, Francesco; Carrizosa, Esteban; Lesch, Stefanie; Billingsley, James; Perez-Ramos, Daniel; Zavala, Fidel; Rheinbay, Esther; Luster, Andrew D; Gerner, Michael Y; Kobold, Sebastian; Pittet, Mikael J; Mempel, Thorsten R.

Cell ; 184(17): 4512-4530.e22, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-34343496

2.

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.

Briukhovetska, Daria; Suarez-Gosalvez, Javier; Voigt, Cornelia; Markota, Anamarija; Giannou, Anastasios D; Schübel, Maryam; Jobst, Jakob; Zhang, Tao; Dörr, Janina; Märkl, Florian; Majed, Lina; Müller, Philipp Jie; May, Peter; Gottschlich, Adrian; Tokarew, Nicholas; Lücke, Jöran; Oner, Arman; Schwerdtfeger, Melanie; Andreu-Sanz, David; Grünmeier, Ruth; Seifert, Matthias; Michaelides, Stefanos; Hristov, Michael; König, Lars M; Cadilha, Bruno Loureiro; Mikhaylov, Oleg; Anders, Hans-Joachim; Rothenfusser, Simon; Flavell, Richard A; Cerezo-Wallis, Daniela; Tejedo, Cristina; Soengas, María S; Bald, Tobias; Huber, Samuel; Endres, Stefan; Kobold, Sebastian.

Immunity ; 56(1): 143-161.e11, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36630913

3.

PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells.

Lacher, Sebastian B; Dörr, Janina; de Almeida, Gustavo P; Hönninger, Julian; Bayerl, Felix; Hirschberger, Anna; Pedde, Anna-Marie; Meiser, Philippa; Ramsauer, Lukas; Rudolph, Thomas J; Spranger, Nadine; Morotti, Matteo; Grimm, Alizee J; Jarosch, Sebastian; Oner, Arman; Gregor, Lisa; Lesch, Stefanie; Michaelides, Stefanos; Fertig, Luisa; Briukhovetska, Daria; Majed, Lina; Stock, Sophia; Busch, Dirk H; Buchholz, Veit R; Knolle, Percy A; Zehn, Dietmar; Dangaj Laniti, Denarda; Kobold, Sebastian; Böttcher, Jan P.

Nature ; 629(8011): 417-425, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38658748

4.

Comparative performance of scFv-based anti-BCMA CAR formats for improved T cell therapy in multiple myeloma.

Stock, Sophia; Fertig, Luisa; Gottschlich, Adrian; Dörr, Janina; Märkl, Florian; Majed, Lina; Menkhoff, Vivien D; Grünmeier, Ruth; Rejeski, Kai; Cordas Dos Santos, David M; Theurich, Sebastian; von Bergwelt-Baildon, Michael; Endres, Stefan; Subklewe, Marion; Kobold, Sebastian.

Cancer Immunol Immunother ; 73(6): 100, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38630291

5.

Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies.

Tsiverioti, Christina Angeliki; Gottschlich, Adrian; Theurich, Sebastian; Anders, Hans-Johachim; Kroiss, Matthias; Kobold, Sebastian; Trefny, Marcel.

Biol Chem ; 2024 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-38766710

6.

Efficient Chimeric Antigen Receptor T-Cell Generation Starting with Leukoreduction System Chambers of Thrombocyte Apheresis Sets.

Xhaxho, Stefani; Chen-Wichmann, Linping; Kreissig, Sophie; Windisch, Roland; Gottschlich, Adrian; Nandi, Sayantan; Schabernack, Sophie; Kohler, Irmgard; Kellner, Christian; Kobold, Sebastian; Humpe, Andreas; Wichmann, Christian.

Transfus Med Hemother ; 51(2): 111-118, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38584695

7.

Mechanisms and strategies for safe chimeric antigen receptor T-cell activity control.

Stock, Sophia; Klüver, Anna-Kristina; Fertig, Luisa; Menkhoff, Vivien D; Subklewe, Marion; Endres, Stefan; Kobold, Sebastian.

Int J Cancer ; 153(10): 1706-1725, 2023 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-37350095

8.

Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy.

Lorenzini, Theo; Cadilha, Bruno L; Obeck, Hannah; Benmebarek, Mohamed-Reda; Märkl, Florian; Michaelides, Stefanos; Strzalkowski, Thaddäus; Briukhovetska, Daria; Müller, Philipp Jie; Nandi, Sayantan; Winter, Pia; Majed, Lina; Grünmeier, Ruth; Seifert, Matthias; Rausch, Svenja; Feuchtinger, Tobias; Endres, Stefan; Kobold, Sebastian.

Br J Cancer ; 129(4): 696-705, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37400680

9.

CD33 BiTE^® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.

Marcinek, Anetta; Brauchle, Bettina; Rohrbacher, Lisa; Hänel, Gerulf; Philipp, Nora; Märkl, Florian; Strzalkowski, Thaddäus; Lacher, Sonja M; Udiljak, Dragica; Spiekermann, Karsten; Theurich, Sebastian; Kobold, Sebastian; Kischel, Roman; James, John R; Bücklein, Veit L; Subklewe, Marion.

Cancer Immunol Immunother ; 72(7): 2499-2512, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37041225

10.

Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor.

McCarthy, Derrick; Lofgren, Michael; Watt, Amy; Horton, Holly; Kieffer-Kwon, Philippe; Ding, Jian; Kobold, Sebastian; Baeuerle, Patrick A; Hofmeister, Robert; Gutierrez, Dario A; Tighe, Robert.

Cancer Immunol Immunother ; 72(12): 4195-4207, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37848682

11.

Impact of the selective A2_AR and A2_BR dual antagonist AB928/etrumadenant on CAR T cell function.

Seifert, Matthias; Benmebarek, Mohamed-Reda; Briukhovetska, Daria; Märkl, Florian; Dörr, Janina; Cadilha, Bruno L; Jobst, Jakob; Stock, Sophia; Andreu-Sanz, David; Lorenzini, Theo; Grünmeier, Ruth; Oner, Arman; Obeck, Hannah; Majed, Lina; Dhoqina, Dario; Feinendegen, Manouk; Gottschlich, Adrian; Zhang, Jin; Schindler, Ulrike; Endres, Stefan; Kobold, Sebastian.

Br J Cancer ; 127(12): 2175-2185, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36266575

12.

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.

Dickopf, Steffen; Buldun, Can; Vasic, Vedran; Georges, Guy; Hage, Carina; Mayer, Klaus; Forster, Matthias; Wessels, Uwe; Stubenrauch, Kay-Gunnar; Benz, Jörg; Ehler, Andreas; Lauer, Matthias E; Ringler, Philippe; Kobold, Sebastian; Endres, Stefan; Klein, Christian; Brinkmann, Ulrich.

Biol Chem ; 403(5-6): 495-508, 2022 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-35073465

13.

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR.

Stenger, Dana; Stief, Tanja A; Kaeuferle, Theresa; Willier, Semjon; Rataj, Felicitas; Schober, Kilian; Vick, Binje; Lotfi, Ramin; Wagner, Beate; Grünewald, Thomas G P; Kobold, Sebastian; Busch, Dirk H; Jeremias, Irmela; Blaeschke, Franziska; Feuchtinger, Tobias.

Blood ; 136(12): 1407-1418, 2020 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-32483603

14.

Determinants of response and resistance to CAR T cell therapy.

Lesch, Stefanie; Benmebarek, Mohamed-Reda; Cadilha, Bruno L; Stoiber, Stefan; Subklewe, Marion; Endres, Stefan; Kobold, Sebastian.

Semin Cancer Biol ; 65: 80-90, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-31705998

15.

Giving T-cell bispecifics a helping hand.

Kobold, Sebastian.

Blood ; 143(21): 2115-2116, 2024 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-38780922

16.

Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.

Simnica, Donjetë; Kobold, Sebastian.

N Engl J Med ; 387(6): 573, 2022 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-35947720

17.

Bifunctional PD-1 × αCD3 × αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.

Herrmann, Monika; Krupka, Christina; Deiser, Katrin; Brauchle, Bettina; Marcinek, Anetta; Ogrinc Wagner, Ana; Rataj, Felicitas; Mocikat, Ralph; Metzeler, Klaus H; Spiekermann, Karsten; Kobold, Sebastian; Fenn, Nadja C; Hopfner, Karl-Peter; Subklewe, Marion.

Blood ; 132(23): 2484-2494, 2018 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-30275109

18.

Cancer cells induce interleukin-22 production from memory CD4⁺ T cells via interleukin-1 to promote tumor growth.

Voigt, Cornelia; May, Peter; Gottschlich, Adrian; Markota, Anamarija; Wenk, Daniel; Gerlach, Inga; Voigt, Sebastian; Stathopoulos, Georgios T; Arendt, Kristina A M; Heise, Constanze; Rataj, Felicitas; Janssen, Klaus-Peter; Königshoff, Melanie; Winter, Hauke; Himsl, Isabelle; Thasler, Wolfgang E; Schnurr, Max; Rothenfußer, Simon; Endres, Stefan; Kobold, Sebastian.

Proc Natl Acad Sci U S A ; 114(49): 12994-12999, 2017 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-29150554

19.

Teaching an old dog new tricks: next-generation CAR T cells.

Tokarew, Nicholas; Ogonek, Justyna; Endres, Stefan; von Bergwelt-Baildon, Michael; Kobold, Sebastian.

Br J Cancer ; 120(1): 26-37, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30413825

20.

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy.

Rataj, Felicitas; Jacobi, Severin J; Stoiber, Stefan; Asang, Florian; Ogonek, Justyna; Tokarew, Nicholas; Cadilha, Bruno L; van Puijenbroek, Erwin; Heise, Constanze; Duewell, Peter; Endres, Stefan; Klein, Christian; Kobold, Sebastian.

Br J Cancer ; 120(1): 79-87, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30429531

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