Volumetric Cuspal Deflection of Premolars Restored With Different Paste-like Bulk-fill Resin Composites Evaluated by Microcomputed Tomography.

OBJECTIVES: The aim of this study was to measure the volumetric cuspal deflection of premolars restored with different paste-like bulk-fill resin composites using microcomputed tomography (micro-CT). METHODS AND MATERIALS: A total of 35 freshly extracted human maxillary second premolars were selected for this study. Standardized large MOD cavities were prepared in each premolar with a bucco-lingual width of 4 mm and a cavity depth of 4 mm measured from the palatal cusp tip. After cavity preparation, all samples were scanned immediately using a micro-CT system. After the initial micro-CT scanning, restorative procedures were performed. Four groups received different paste-like bulk-fill composites-Beautifil-Bulk Restorative (BBR), Admira Fusion x-tra (AFX), x-tra fill, and Sonic Fill-and the control group received a conventional universal composite and Clearfil Majesty Esthetic (CME). Immediately after the restorative procedure, each tooth was scanned by micro-CT in the same manner as the initial scanning. The buccal and palatal regions of each restoration were evaluated separately in terms of cuspal deflection. One-way analysis of variance was used to compare the effect of the composite resin, and multiple comparisons were performed by the Tukey test with a level of significance of α = 0.05. RESULTS AND DISCUSSION: Multiple comparisons showed that teeth restored with the conventional paste-like composite and CME (control) had significantly different cuspal deflection from those filled with paste-like bulk-fill composites (p<0.05). Among the bulk-fill composites, a significant difference was observed between BBR and AFX (p<0.05). CONCLUSIONS: Paste-like bulk-fill resin composites had significantly lower cuspal deflection than the conventional paste-like resin composite tested.

Morphometric analysis of vidian canal and its relations with surrounding anatomic structures by using cone-beam computed tomography.

BACKGROUND: We identified the vidian canal (VC) in a Turkish subpopulation on cone-beam computed tomography (CBCT) images and explored its anatomic relationships; the canal serves as an anatomic pathway during endonasal surgical approaches. MATERIALS AND METHODS: Coronal and axial CBCT images of 100 patients (50 males and 50 females) were evaluated (slice thickness and interval, 0.5 mm). We measured the length of the VC length, extent of VC pneumatisation into the sphenoid sinus, position of the VC relative to the medial pterygopalatine plate (MPP), pterygopalatine fossa (PPF) depth, and VC-VC, VC-MPP, and VC-foramen rotundum (FR) distances, the angle between the posterior end of the middle turbinate and the lateral part of the VC anterior opening, and the angle between the VC and the palatovaginal canal. RESULTS: The mean VC length was 13.09 ± 2.07 and 13.01 ± 2.12 mm on the right and left sides, respectively. Relative to the MPP, the VC was located medially in 54.5% of patients, on the same level in 36%, and laterally in 9.5%. Pneumatisation was of grade I in 24% of patients, grade II in 33%, grade III in 23.5%, and grade IV in 19.5%. The VC-FR and VC-MPP distances were significantly greater on the left side. The angle between the posterior end of the middle turbinate and the lateral part of the anterior VC opening was significantly greater on the right side. The VC-VC distance was significantly greater when the VC lay lateral to the MPP. CONCLUSIONS: Anatomic characteristics of the VC on CBCT images unique to Turkish populations should be kept in mind during surgery.

Accuracy of two different voxel sizes for presurgical evaluation of mandibular osteotomy.

The aim of this study was to compare the accuracy of two different voxel resolutions for the preoperative assessment of mandibular osteotomies. The study was conducted on 37 dry adult human mandibles. To obtain measurement standardization, heated gutta-percha cones were placed on the dry mandibles to mark 20 anatomical points. These cones were used for all measurement groups. Cone beam computerized tomography (CBCT) scans of the mandibles were made using 0.200mm3 and 0.400mm3 voxel sizes (Planmeca Promex-3D Helsinki, Finland). The results obtained from these two groups were compared with physical measurements obtained using a digital calliper, in order to analyze their predictive value. In the study, one voxel size did not have supremacy over the other in terms of accuracy. For mandibular osteotomies, 0.400mm3 voxel size can be preferred because of lower radiation dose.

Comparison of the influence of FOV sizes and different voxel resolutions for the assessment of periodontal defects.

OBJECTIVES: This study assessed the influence of different voxel resolutions of two different CBCT units on the in vitro detection of periodontal defects. METHODS: The study used 12 dry skulls with a maxilla and a mandible. Artificial defects (dehiscence, tunnel, fenestration) were separately created on the anterior, premolar and molar teeth using burrs. A total of 14 dehiscences, 13 fenestrations, 8 tunnels and 16 non-defect controls were used in the study. Images were obtained from two different CBCT units in six voxel sizes (voxel size: 0.080, 0.100, 0.125, 0.150, 0.160 and 0.200 mm3). Kappa coefficients were calculated to assess both intra- and interobserver agreements for each image set. RESULTS: Overall intraobserver kappa coefficients ranged between 0.978 and 0.973 for the 0.080-mm3 images and between 0.751 and 0.737 for the 0.160-mm3 images, suggesting notably high intraobserver agreement for detecting periodontal defects. CBCT performed significantly better at detecting fenestrations (p<0.05) than tunnel and dehiscence defects. No statistically significant difference was found between the detection of dehiscence and tunnel defects (p>0.05). CONCLUSIONS: A voxel size of 0.150 mm3 was identified as the cut-off point for overall detection of periodontal defects. CBCT should be considered the most reliable imaging modality for the diagnosis of periodontal defects.

Cisplatin, mitomycin, and interferon-alpha2a combination chemoimmunotherapy in the treatment of diffuse malignant pleural mesothelioma.

STUDY OBJECTIVE: To investigate the therapeutic activity and toxicity of combination chemoimmunotherapy with cisplatin, mitomycin, and interferon (IFN)-alpha2a, by comparing the responses in a group of patients with diffuse malignant pleural mesothelioma (DMPM) to the responses in a control group of DMPM patients given supportive care alone. DESIGN: Patients with histopathologically confirmed DMPM were evaluated for treatment with chemoimmunotherapy. SETTING: After the initial evaluation, all patients received either chemoimmunotherapy or supportive care from the Osmangazi University Medical Faculty, Department of Chest Diseases. PATIENTS: Forty-three patients with DMPM received chemoimmunotherapy until the end of the survey; 19 patients were given supportive therapy alone after refusing chemoimmunotherapy. INTERVENTIONS: Drugs were administered according to the following schedule: IV cisplatin, 30 mg/m2 qd on days 1 and 2; IV mitomycin, 8 mg/m2 on day 1; and subcutaneous IFN-alpha2a, 4.5 million IU twice weekly. The courses were repeated every 4 weeks. RESULTS: Overall, 232 chemoimmunotherapy cycles were administered. A total of 10 objective responses (ORs) in 43 patients (23%) were assessed, including 2 complete responses (5%), 4 partial responses, and 4 regressions. Seventeen patients had stable disease, and 16 patients had progression. The median survival time was 11.5 months for the 43 patients who received chemoimmunotherapy and 7.0 months for the 19 patients who received supportive therapy alone. The difference in survival times between the chemoimmunotherapy and supportive therapy groups was not significant. However, the median survival time for the patients who had OR was 21.3 months, which is significantly longer than that of the patients who received supportive care alone and that of patients with progressive disease (6 months). The toxicities associated with the treatment schedule of this study were, for the most part, tolerable. CONCLUSIONS: The drug combination used in this study is moderately effective and well tolerated in patients with DMPM, especially in those who responded to the treatment.

The prevalence of asthma and allergy among university freshmen in Eskisehir, Turkey.

The aim of this study was to determine the current and cumulative prevalence of asthma, allergic rhinitis, atopic dermatitis and reactivities to allergen skin prick tests (SPT) among university freshmen. The data at the first stage were collated through the application of the European Community Respiratory Health Survey (-ECRHS-Stage I) questionnaire on 1603 students registering at various faculties and vocational colleges of Osmangazi University in Eskisehir, Turkey, in the academic year 1997-1998. At the second stage a physical examination as well as allergen SPTs were conducted on 151 students. Of the students within the study group, six (0.4%) had experienced an asthma attack within the previous 12 months, 11 (0.7%) had a past of asthma attacks and 123 (8.1%) reported wheezing attacks within the previous 12 months. The prevalence of asthma-like symptoms, rhinoconjunctivitis and dermatitis were found to be 17.0%, 10.0% and 5.9% respectively. Asthma and asthma-like symptoms were found to be significantly more prevalent among students who smoked. A positive SPT reaction to more than one allergen was found in 14.6% of the students. SPT positivity was 8.3% in asymptomatic students, 27.3% in asthmatic students, 14.5% in those with asthma-like symptoms, 28% in those with non-infectious rhinitis and 7.1% in those with dermatitis. In analysis of logistic regression, a history of atopy, as ascertained in the questionnaire, was seen to have a significant effect on SPT positivity. The rate of self-reported asthma and/or asthma-like symptoms among newly enrolled freshmen at the Osmangazi University was found to be lower than in other countries. Cigarette smoking was seen to increase such symptoms significantly, in comparison to non-smokers.

Environmental asbestos exposure and malignant pleural mesothelioma.

Asbestos-related benign and malignant pleural diseases are endemic in some rural parts of central Turkey because of environmental exposure to asbestos fibres. We report here epidemiological data on 113 patients with diffuse malignant pleural mesothelioma (DMPM) diagnosed in our clinic in Eskisehir, located in central Turkey. Of the 113 patients, 59 were men and 54 women (male:female ratio = 1). Ninety-seven patients (86%) had non-occupational asbestos exposure; all were living in villages. Their mean age was 56 years. As the patients had been exposed to asbestos from birth, the latency period was equivalent to the age of the patients. Twenty-eight patients (29%) had lived in villages their entire lives. The other 69 (71%) had been born in a village but migrated to the city or had given up white-soil usage for various reasons. The mean exposure time was 55 years for those with a long exposure period and 25 years for those with a short exposure period, but there was no significant difference between the age of the disease appearance for both groups (55 and 56 years, respectively). Thus, the latency time of mesothelioma due to environmental exposure to asbestos was longer than that due to occupational exposure, but independent of the length of exposure. Soil samples from 67 villages were analysed, comprising a population of 10,120 villagers. Tremolite and some other types of asbestos were found. In conclusion, DMPM in our region is due to mainly to environmental exposure to asbestos. The risk is substantial as a large proportion of the villagers are exposed. After smoking, asbestos exposure is one of the most serious health hazards in our rural population.

T lymphocyte activation in bronchoalveolar lavage of patients with interstitial lung disease.

To study the role of T-lymphocytes in the patients with alveolitis due to interstitial lung disease (ILD), we have examined T cell populations in bronchoalveolar lavage (BAL) and peripheral blood (PB) of ten patients with ILD and six normal-controls via flow cytometry. The percentages of T-lymphocytes bearing the activation markers of HLA-DR (p < 0.01) and CD25 (p < 0.05) were significantly higher in BAL of ILD patients. There was no correlation between T lymphocytes subtypes and pulmonary functions and diffusion capacity (p > 0.05). In PB of ILD patients had less CD4+ T lymphocytes and CD19 cells (B lymphocytes) than controls (p < 0.05). This increased T-lymphocyte activation in BAL in contrast to PB suggested to have a role in the pathogenesis of the lung involvement in ILD.

Prevalence of occupational asthma among automobile and furniture painters in the center of Eskisehir (Turkey): the effects of atopy and smoking habits on occupational asthma.

BACKGROUND: Occupational asthma (OA) is a respiratory disorder characterized by airway hyperreactivity caused by agents present in the workplace. For determination of the prevalence of OA among car and furniture painters exposed to isocyanate in the center of Eskisehir, Turkey, a clinical and epidemiologic prospective study in three phases was done, incorporating 312 (89.4%) of the painters. METHODS: Of these subjects, 190 (61%) were furniture painters and 122 (39%) automobile painters. In the first phase of the study, a modified questionnaire and pulmonary function test (PFT) were done. During the second phase, peak expiratory flow rate (PEFR) was monitored in 52 subjects whose complaints were confirmed and who agreed to a month of such monitoring. In the third phase, nonspecific bronchial provocation tests (NSBPT) with histamine were done on 23 of the PEFR-monitored workers. RESULTS: Finally, through questionnaire, typical history, PFT, PEFR monitoring, and NSBPT, 30 workers (9.6%) were diagnosed as having OA. Smoking habits and atopy in the OA-diagnosed workers were found to be statistically significantly high in comparison to the other workers. CONCLUSIONS: It was concluded that OA is a common disorder among automobile and furniture painters, and smoking habits and atopy were seen to have a significant effect on OA occurrence.