Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mechanisms of Deubiquitinase Specificity and Regulation.

Mevissen, Tycho E T; Komander, David.

Annu Rev Biochem ; 86: 159-192, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28498721

2.

Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague, Michael J; Urbé, Sylvie; Komander, David.

Nat Rev Mol Cell Biol ; 20(5): 321, 2019 May.

Artigo em Inglês | MEDLINE | ID: mdl-30783221

3.

Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague, Michael J; Urbé, Sylvie; Komander, David.

Nat Rev Mol Cell Biol ; 20(6): 338-352, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30733604

4.

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Damgaard, Rune Busk; Walker, Jennifer A; Marco-Casanova, Paola; Morgan, Neil V; Titheradge, Hannah L; Elliott, Paul R; McHale, Duncan; Maher, Eamonn R; McKenzie, Andrew N J; Komander, David.

Cell ; 166(5): 1215-1230.e20, 2016 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-27523608

5.

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.

Keusekotten, Kirstin; Elliott, Paul Ronald; Glockner, Laura; Fiil, Berthe Katrine; Damgaard, Rune Busk; Kulathu, Yogesh; Wauer, Tobias; Hospenthal, Manuela Kathrin; Gyrd-Hansen, Mads; Krappmann, Daniel; Hofmann, Kay; Komander, David.

Cell ; 153(6): 1312-26, 2013 Jun 06.

Artigo em Inglês | MEDLINE | ID: mdl-23746843

6.

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

Mevissen, Tycho E T; Hospenthal, Manuela K; Geurink, Paul P; Elliott, Paul R; Akutsu, Masato; Arnaudo, Nadia; Ekkebus, Reggy; Kulathu, Yogesh; Wauer, Tobias; El Oualid, Farid; Freund, Stefan M V; Ovaa, Huib; Komander, David.

Cell ; 154(1): 169-84, 2013 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-23827681

7.

Activation mechanism of PINK1.

Gan, Zhong Yan; Callegari, Sylvie; Cobbold, Simon A; Cotton, Thomas R; Mlodzianoski, Michael J; Schubert, Alexander F; Geoghegan, Niall D; Rogers, Kelly L; Leis, Andrew; Dewson, Grant; Glukhova, Alisa; Komander, David.

Nature ; 602(7896): 328-335, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34933320

8.

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.

Ordureau, Alban; Paulo, Joao A; Zhang, Jiuchun; An, Heeseon; Swatek, Kirby N; Cannon, Joe R; Wan, Qiaoqiao; Komander, David; Harper, J Wade.

Mol Cell ; 77(5): 1124-1142.e10, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-32142685

9.

The ubiquitin code.

Komander, David; Rape, Michael.

Annu Rev Biochem ; 81: 203-29, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22524316

10.

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.

Gersch, Malte; Wagstaff, Jane L; Toms, Angela V; Graves, Bradford; Freund, Stefan M V; Komander, David.

Mol Cell ; 74(3): 436-451.e7, 2019 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-30926242

11.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Annibaldi, Alessandro; Wicky John, Sidonie; Vanden Berghe, Tom; Swatek, Kirby N; Ruan, Jianbin; Liccardi, Gianmaria; Bianchi, Katiuscia; Elliott, Paul R; Choi, Sze Men; Van Coillie, Samya; Bertin, John; Wu, Hao; Komander, David; Vandenabeele, Peter; Silke, John; Meier, Pascal.

Mol Cell ; 69(4): 566-580.e5, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29452637

12.

Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis.

Liu, Zikou; Dagley, Laura F; Shield-Artin, Kristy; Young, Samuel N; Bankovacki, Aleksandra; Wang, Xiangyi; Tang, Michelle; Howitt, Jason; Stafford, Che A; Nachbur, Ueli; Fitzgibbon, Cheree; Garnish, Sarah E; Webb, Andrew I; Komander, David; Murphy, James M; Hildebrand, Joanne M; Silke, John.

EMBO J ; 40(23): e103718, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34698396

13.

Insights into ubiquitin chain architecture using Ub-clipping.

Swatek, Kirby N; Usher, Joanne L; Kueck, Anja F; Gladkova, Christina; Mevissen, Tycho E T; Pruneda, Jonathan N; Skern, Tim; Komander, David.

Nature ; 572(7770): 533-537, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31413367

14.

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.

Michel, Martin A; Swatek, Kirby N; Hospenthal, Manuela K; Komander, David.

Mol Cell ; 68(1): 233-246.e5, 2017 Oct 05.

Artigo em Inglês | MEDLINE | ID: mdl-28943312

15.

Identification and characterization of diverse OTU deubiquitinases in bacteria.

Schubert, Alexander F; Nguyen, Justine V; Franklin, Tyler G; Geurink, Paul P; Roberts, Cameron G; Sanderson, Daniel J; Miller, Lauren N; Ovaa, Huib; Hofmann, Kay; Pruneda, Jonathan N; Komander, David.

EMBO J ; 39(15): e105127, 2020 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-32567101

16.

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

Klemm, Theresa; Ebert, Gregor; Calleja, Dale J; Allison, Cody C; Richardson, Lachlan W; Bernardini, Jonathan P; Lu, Bernadine Gc; Kuchel, Nathan W; Grohmann, Christoph; Shibata, Yuri; Gan, Zhong Yan; Cooney, James P; Doerflinger, Marcel; Au, Amanda E; Blackmore, Timothy R; van der Heden van Noort, Gerbrand J; Geurink, Paul P; Ovaa, Huib; Newman, Janet; Riboldi-Tunnicliffe, Alan; Czabotar, Peter E; Mitchell, Jeffrey P; Feltham, Rebecca; Lechtenberg, Bernhard C; Lowes, Kym N; Dewson, Grant; Pellegrini, Marc; Lessene, Guillaume; Komander, David.

EMBO J ; 39(18): e106275, 2020 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-32845033

17.

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

Kulathu, Yogesh; Komander, David.

Nat Rev Mol Cell Biol ; 13(8): 508-23, 2012 Jul 23.

Artigo em Inglês | MEDLINE | ID: mdl-22820888

18.

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

Rahighi, Simin; Ikeda, Fumiyo; Kawasaki, Masato; Akutsu, Masato; Suzuki, Nobuhiro; Kato, Ryuichi; Kensche, Tobias; Uejima, Tamami; Bloor, Stuart; Komander, David; Randow, Felix; Wakatsuki, Soichi; Dikic, Ivan.

Cell ; 136(6): 1098-109, 2009 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-19303852

19.

Mechanism of parkin activation by PINK1.

Gladkova, Christina; Maslen, Sarah L; Skehel, J Mark; Komander, David.

Nature ; 559(7714): 410-414, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29995846

20.

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.

Pruneda, Jonathan N; Durkin, Charlotte H; Geurink, Paul P; Ovaa, Huib; Santhanam, Balaji; Holden, David W; Komander, David.

Mol Cell ; 63(2): 261-276, 2016 07 21.

Artigo em Inglês | MEDLINE | ID: mdl-27425412

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