Detalhe da pesquisa
1.
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.
Europace
; 18(9): 1287-98, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26622055
2.
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.
Proc Natl Acad Sci U S A
; 106(24): 9896-901, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19482941
3.
The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells.
Channels (Austin)
; 15(1): 239-252, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465001
4.
Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes.
J Pharmacol Toxicol Methods
; 104: 106896, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32622755
5.
Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+ß1 Model.
Front Pharmacol
; 10: 1374, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31920633
6.
Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
Toxicol Sci
; 170(2): 345-356, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31020317
7.
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.
Toxicon
; 51(6): 974-83, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313714
8.
Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.
J Pharmacol Toxicol Methods
; 91: 80-86, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29421525
9.
Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking.
Stem Cell Reports
; 11(6): 1365-1377, 2018 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30540961
10.
Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.
Br J Pharmacol
; 174(21): 3766-3779, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094846
11.
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.
Toxicon
; 120: 57-60, 2016 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27475861
12.
Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.
Neuropharmacology
; 107: 160-167, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956727
13.
Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Stem Cells Transl Med
; 5(5): 602-12, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27034410
14.
Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.
Sci Rep
; 5: 17402, 2015 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26616025
15.
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
J Gen Physiol
; 141(3): 359-69, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23401573
16.
Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily.
Biochem Pharmacol
; 83(9): 1307-17, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22305749