Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

IL-23 stabilizes an effector T_reg cell program in the tumor microenvironment.

Wertheimer, Tobias; Zwicky, Pascale; Rindlisbacher, Lukas; Sparano, Colin; Vermeer, Marijne; de Melo, Bruno Marcel Silva; Haftmann, Claudia; Rückert, Tamina; Sethi, Aakriti; Schärli, Stefanie; Huber, Anna; Ingelfinger, Florian; Xu, Caroline; Kim, Daehong; Häne, Philipp; Fonseca da Silva, André; Muschaweckh, Andreas; Nunez, Nicolas; Krishnarajah, Sinduya; Köhler, Natalie; Zeiser, Robert; Oukka, Mohamed; Korn, Thomas; Tugues, Sonia; Becher, Burkhard.

Nat Immunol ; 25(3): 512-524, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38356059

2.

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.

Scherer, Stefanie; Oberle, Susanne G; Kanev, Kristiyan; Gerullis, Ann-Katrin; Wu, Ming; de Almeida, Gustavo P; Puleston, Daniel J; Baixauli, Francesc; Aly, Lilian; Greco, Alessandro; Nizharadze, Tamar; Becker, Nils B; Hoesslin, Madlaina V; Donhauser, Lara V; Berner, Jacqueline; Chu, Talyn; McNamara, Hayley A; Esencan, Zeynep; Roelli, Patrick; Wurmser, Christine; Kleiter, Ingo; Vehreschild, Maria J G T; Mayer, Christoph A; Knolle, Percy; Klingenspor, Martin; Fumagalli, Valeria; Iannacone, Matteo; Prlic, Martin; Korn, Thomas; Pearce, Erika L; Höfer, Thomas; Schulz, Anna M; Zehn, Dietmar.

Nat Immunol ; 24(3): 501-515, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36797499

3.

Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology.

Haimon, Zhana; Frumer, Gal Ronit; Kim, Jung-Seok; Trzebanski, Sébastien; Haffner-Krausz, Rebecca; Ben-Dor, Shifra; Porat, Ziv; Muschaweckh, Andreas; Chappell-Maor, Louise; Boura-Halfon, Sigalit; Korn, Thomas; Jung, Steffen.

Nat Immunol ; 23(12): 1749-1762, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36456736

4.

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.

Korn, Thomas.

Cell ; 176(3): 416-418, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30682369

5.

Repositioning T_H cell polarization from single cytokines to complex help.

Tuzlak, Selma; Dejean, Anne S; Iannacone, Matteo; Quintana, Francisco J; Waisman, Ari; Ginhoux, Florent; Korn, Thomas; Becher, Burkhard.

Nat Immunol ; 22(10): 1210-1217, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34545250

6.

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.

Hiltensperger, Michael; Beltrán, Eduardo; Kant, Ravi; Tyystjärvi, Sofia; Lepennetier, Gildas; Domínguez Moreno, Helena; Bauer, Isabel J; Grassmann, Simon; Jarosch, Sebastian; Schober, Kilian; Buchholz, Veit R; Kenet, Selin; Gasperi, Christiane; Öllinger, Rupert; Rad, Roland; Muschaweckh, Andreas; Sie, Christopher; Aly, Lilian; Knier, Benjamin; Garg, Garima; Afzali, Ali M; Gerdes, Lisa Ann; Kümpfel, Tania; Franzenburg, Sören; Kawakami, Naoto; Hemmer, Bernhard; Busch, Dirk H; Misgeld, Thomas; Dornmair, Klaus; Korn, Thomas.

Nat Immunol ; 22(7): 880-892, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34099917

7.

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler, Paul K; Bollrath, Julia; Pallangyo, Charles K; Matsutani, Takaji; Canli, Özge; De Oliveira, Tiago; Diamanti, Michaela A; Müller, Nina; Gamrekelashvili, Jaba; Putoczki, Tracy; Horst, David; Mankan, Arun K; Öner, Meryem G; Müller, Susanna; Müller-Höcker, Josef; Kirchner, Thomas; Slotta-Huspenina, Julia; Taketo, M Mark; Reinheckel, Thomas; Dröse, Stefan; Larner, Andrew C; Wels, Winfried S; Ernst, Matthias; Greten, Tim F; Arkan, Melek C; Korn, Thomas; Wirth, Dagmar; Greten, Florian R.

Cell ; 174(1): 88-101.e16, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29909986

8.

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.

Baumann, Tobias; Dunkel, Andreas; Schmid, Christian; Schmitt, Sabine; Hiltensperger, Michael; Lohr, Kerstin; Laketa, Vibor; Donakonda, Sainitin; Ahting, Uwe; Lorenz-Depiereux, Bettina; Heil, Jan E; Schredelseker, Johann; Simeoni, Luca; Fecher, Caroline; Körber, Nina; Bauer, Tanja; Hüser, Norbert; Hartmann, Daniel; Laschinger, Melanie; Eyerich, Kilian; Eyerich, Stefanie; Anton, Martina; Streeter, Matthew; Wang, Tina; Schraven, Burkhart; Spiegel, David; Assaad, Farhah; Misgeld, Thomas; Zischka, Hans; Murray, Peter J; Heine, Annkristin; Heikenwälder, Mathias; Korn, Thomas; Dawid, Corinna; Hofmann, Thomas; Knolle, Percy A; Höchst, Bastian.

Nat Immunol ; 21(5): 555-566, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32327756

9.

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; Lepennetier, Gildas; Engleitner, Thomas; Garg, Garima; Muschaweckh, Andreas; Mitsdörffer, Meike; Koedel, Uwe; Höchst, Bastian; Knolle, Percy; Gunzer, Matthias; Hemmer, Bernhard; Rad, Roland; Merkler, Doron; Korn, Thomas.

Nat Immunol ; 19(12): 1341-1351, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30374128

10.

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Afzali, Ali Maisam; Nirschl, Lucy; Sie, Christopher; Pfaller, Monika; Ulianov, Oleksii; Hassler, Tobias; Federle, Christine; Petrozziello, Elisabetta; Kalluri, Sudhakar Reddy; Chen, Hsin Hsiang; Tyystjärvi, Sofia; Muschaweckh, Andreas; Lammens, Katja; Delbridge, Claire; Büttner, Andreas; Steiger, Katja; Seyhan, Gönül; Ottersen, Ole Petter; Öllinger, Rupert; Rad, Roland; Jarosch, Sebastian; Straub, Adrian; Mühlbauer, Anton; Grassmann, Simon; Hemmer, Bernhard; Böttcher, Jan P; Wagner, Ingrid; Kreutzfeldt, Mario; Merkler, Doron; Pardàs, Irene Bonafonte; Schmidt Supprian, Marc; Buchholz, Veit R; Heink, Sylvia; Busch, Dirk H; Klein, Ludger; Korn, Thomas.

Nature ; 627(8003): 407-415, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38383779

11.

CNS T_reg cells have alternative functions but run on conventional fuel.

Korn, Thomas.

Nat Immunol ; 23(6): 818-819, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35618830

12.

Reply to 'Comment on: Repositioning T_H cell polarization from single cytokines to complex help'.

Tuzlak, Selma; Ginhoux, Florent; Korn, Thomas; Becher, Burkhard.

Nat Immunol ; 23(4): 503-504, 2022 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-35190719

13.

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells.

Heink, Sylvia; Yogev, Nir; Garbers, Christoph; Herwerth, Marina; Aly, Lilian; Gasperi, Christiane; Husterer, Veronika; Croxford, Andrew L; Möller-Hackbarth, Katja; Bartsch, Harald S; Sotlar, Karl; Krebs, Stefan; Regen, Tommy; Blum, Helmut; Hemmer, Bernhard; Misgeld, Thomas; Wunderlich, Thomas F; Hidalgo, Juan; Oukka, Mohamed; Rose-John, Stefan; Schmidt-Supprian, Marc; Waisman, Ari; Korn, Thomas.

Nat Immunol ; 18(1): 74-85, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27893700

14.

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Sledzinska, Anna; Vila de Mucha, Maria; Bergerhoff, Katharina; Hotblack, Alastair; Demane, Dafne Franz; Ghorani, Ehsan; Akarca, Ayse U; Marzolini, Maria A V; Solomon, Isabelle; Vargas, Frederick Arce; Pule, Martin; Ono, Masahiro; Seddon, Benedict; Kassiotis, George; Ariyan, Charlotte E; Korn, Thomas; Marafioti, Teresa; Lord, Graham M; Stauss, Hans; Jenner, Richard G; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 52(1): 151-166.e6, 2020 01 14.

Artigo em Inglês | MEDLINE | ID: mdl-31924474

15.

Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.

Bauer, Isabel J; Fang, Ping; Lämmle, Katrin F; Tyystjärvi, Sofia; Alterauge, Dominik; Baumjohann, Dirk; Yoon, Hongsup; Korn, Thomas; Wekerle, Hartmut; Kawakami, Naoto.

Proc Natl Acad Sci U S A ; 120(30): e2302697120, 2023 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-37467267

16.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

Schmidt, Henrik; Raj, Timsse; O'Neill, Thomas J; Muschaweckh, Andreas; Giesert, Florian; Negraschus, Arlinda; Hoefig, Kai P; Behrens, Gesine; Esser, Lena; Baumann, Christina; Feederle, Regina; Plaza-Sirvent, Carlos; Geerlof, Arie; Gewies, Andreas; Isay, Sophie E; Ruland, Jürgen; Schmitz, Ingo; Wurst, Wolfgang; Korn, Thomas; Krappmann, Daniel; Heissmeyer, Vigo.

Proc Natl Acad Sci U S A ; 120(48): e2309205120, 2023 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-37988467

17.

The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the T_H17 lineage in humans.

Mitsdoerffer, Meike; Aly, Lilian; Barz, Melanie; Engleitner, Thomas; Sie, Christopher; Delbridge, Claire; Lepennetier, Gildas; Öllinger, Rupert; Pfaller, Monika; Wiestler, Benedikt; Rad, Roland; Meyer, Bernhard; Knier, Benjamin; Schmidt-Graf, Friederike; Gempt, Jens; Korn, Thomas.

Proc Natl Acad Sci U S A ; 119(34): e2206208119, 2022 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-35969754

18.

Foxp3⁺ regulatory T cells in the central nervous system and other nonlymphoid tissues.

Korn, Thomas.

Eur J Immunol ; 53(8): e2250227, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37143298

19.

Disentangling the manifold functions of RORÎ³t.

Korn, Thomas.

Nat Immunol ; 18(10): 1059-1060, 2017 09 19.

Artigo em Inglês | MEDLINE | ID: mdl-28926531

20.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells.

Heink, Sylvia; Yogev, Nir; Garbers, Christoph; Herwerth, Marina; Aly, Lilian; Gasperi, Christiane; Husterer, Veronika; Croxford, Andrew L; Möller-Hackbarth, Katja; Bartsch, Harald S; Sotlar, Karl; Krebs, Stefan; Regen, Tommy; Blum, Helmut; Hemmer, Bernhard; Misgeld, Thomas; Wunderlich, Thomas F; Hidalgo, Juan; Oukka, Mohamed; Rose-John, Stefan; Schmidt-Supprian, Marc; Waisman, Ari; Korn, Thomas.

Nat Immunol ; 18(4): 474, 2017 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-28323263

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IL-23 stabilizes an effector T_reg cell program in the tumor microenvironment.

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.

Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology.

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.

Repositioning T_H cell polarization from single cytokines to complex help.

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

CNS T_reg cells have alternative functions but run on conventional fuel.

Reply to 'Comment on: Repositioning T_H cell polarization from single cytokines to complex help'.

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells.

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the T_H17 lineage in humans.

Foxp3⁺ regulatory T cells in the central nervous system and other nonlymphoid tissues.

Disentangling the manifold functions of RORÎ³t.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells.