RESUMO
BACKGROUND: Sweat(ing) is a common aggravating factor of atopic dermatitis (AD), and many school children with AD experience the exacerbation of their disease in summer. OBJECTIVE: We evaluated the usefulness of taking shower at the school for the management of AD in summer. METHODS: Fifty-eight school children with moderate or severer atopic dermatitis were enrolled in the study. Subjects were allocated to one of following groups, group A: no shower (n=15), group B: 4-weeks shower (n=22), group C1: 2-weeks shower in the first half (n=11), or group C2: 2-weeks shower in the latter half (n=10), and took (or did not take) shower at the school from the beginning of September. Disease severity was evaluated on day 0, 2 weeks later and 4 weeks later using SCORAD scoring system. RESULTS: Significant improvements in SCORAD scores after 4 weeks were observed only in groups B and C1. When the subjects were sub-divided by the severity of the disease, the significant effect of shower was limited to the patients with severe and most severe disease. Similar results were obtained with a modified SCORAD score in which subjective symptoms were excluded. CONCLUSION: It is useful to take showers at the school for the management of AD for the children with severer disease.
Assuntos
Banhos , Dermatite Atópica/terapia , Instituições Acadêmicas , Adolescente , Criança , Dermatite Atópica/etiologia , Dermatite Atópica/prevenção & controle , Humanos , Estações do Ano , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Substance P (SP) selectively activates mast cells that reside in connective tissues. We studied the reactions of bone marrow-derived mast cells (BMMC) of three mouse strains, cultured with or without fibroblasts. BMMC co-cultured with fibroblasts, but not those cultured alone, increased intracellular Ca(2+), released LTB(4) and histamine in response to SP. PD098059 significantly inhibited the release of LTB(4), but not histamine in all strains. SB203580 failed to reduce or slightly impaired the release of LTB(4). These results suggest that mast cells undergo maturation under the influence of fibroblasts, acquiring the responsiveness to SP with Ca(2+) signals and predominantly ERK-MAP kinase.
Assuntos
Sinalização do Cálcio/efeitos dos fármacos , Leucotrieno B4/metabolismo , Mastócitos/efeitos dos fármacos , Mastócitos/metabolismo , Substância P/imunologia , Substância P/farmacologia , Animais , Células da Medula Óssea/citologia , Células da Medula Óssea/efeitos dos fármacos , Células da Medula Óssea/metabolismo , Cálcio/metabolismo , Sinalização do Cálcio/imunologia , Técnicas de Cocultura , Inibidores Enzimáticos/farmacologia , Fibroblastos/citologia , Flavonoides/farmacologia , Liberação de Histamina/efeitos dos fármacos , Imidazóis/farmacologia , Masculino , Mastócitos/citologia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Proteínas Quinases Ativadas por Mitógeno/antagonistas & inibidores , Proteínas Quinases Ativadas por Mitógeno/metabolismo , Células NIH 3T3 , Piridinas/farmacologia , Especificidade da Espécie , Substância P/metabolismoRESUMO
The Japanese Dermatological Association established an advisory committee in 1995 to develop a severity scoring system for atopic dermatitis (AD). Its interim and concluding reports were published in Japanese in the Japanese Journal of Dermatology (108: 1491-1496, 1998 and 111: 2023-2033, 2001). Because of the strong demand for an English version, we have decided to publish the reports in English. This manuscript is the English version of the concluding report. The interim report suggested that eruption components such as erythema, papule, erosion, crust, excoriation and lichenification with extent of involved areas in five body regions, including the head and neck, anterior and posterior trunks, and upper and lower limbs, were important items for assessing AD severity. Additionally, it was recommended that streamlining of eruption components was mandatory for improving the statistical validity and reliability. The committee members subsequently concentrated their efforts on this task, and finally proposed an Atopic Dermatitis Severity Classification Criteria of the Japanese Dermatological Association.
Assuntos
Dermatite Atópica/classificação , Adulto , Comitês Consultivos , Idoso , Dermatite Atópica/complicações , Dermatite Atópica/diagnóstico , Feminino , Humanos , Japão , Idioma , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Prurido/etiologia , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Sociedades Médicas , Adulto JovemRESUMO
Sweating aggravates itch in atopic dermatitis, but the mechanism is unclear. In this study, we examined the involvement of type I hypersensitivity in the aggravation of atopic dermatitis by sweating. Skin tests with autologous sweat were positive in 56 of 66 patients (84.4%) with atopic dermatitis, but only in 3 of 27 healthy volunteers (11.1%). Sweat samples from both patients and healthy volunteers induced varying degrees of histamine release from basophils of patients with atopic dermatitis. However, the histamine release was impaired by removal of IgE on the basophils. Incubation of basophils with myeloma IgE before sensitization with serum of patients blocked the ability to release histamine-induced sweat. IgE antibody against antigen(s) in sweat may be present in serum of patients with atopic dermatitis. Key words: