Dual-key-based adaptive watermark embedding for light field 3D images.

The existing methods fail to effectively utilize the viewpoint information of light field 3D images for watermark embedding which results in a serious decrease in both invisibility and robustness of the watermark. Therefore, we propose a novel, to the best of our knowledge, light field 3D dual-key-based watermarking network (3D-DKWN). Our method employs a pixel mapping algorithm to obtain the disparity sub-image of the light field 3D image and generates an encoding key (EK). Adaptive watermark embedding is then performed on the disparity sub-image and a steganographic key (SK) is generated. Finally, the light field 3D image with the embedded watermark is reconstructed. Compared with previous approaches, our method reasonably utilizes the viewpoint information of light field 3D images, resulting in the significant improvement of invisibility and robustness of the watermark.

Preliminary evidence for therapeutic impact of intravesical glucosamine on protamine sulfate and potassium chloride-induced bladder overactivity in rat model.

PURPOSE: To investigate the protective effect of intravesical glucosamine in treating overactive bladder (OAB). METHODS: Ninety-two female Sprague-Dawley (SD) rats were divided into 4 groups i.e. protamine sulfate (PS), N-acetylcysteine (NAC), and glucosamine-treated PS (GPS), and normal saline control (NC) were used. We induced hyperactivity in rats via intravesical infusion of PS and potassium chloride (KCl), whereas the NC group underwent a sustained intravesical saline infusion for 1 h. N-acetylcysteine (NAC), a potential antioxidant as well as anti-inflammatory agent was employed as positive control. Cystometrography (CMG) was then conducted to determine urodynamic parameters, i.e., leak point pressure (LPP, n = 48) and inter-contractile interval, the duration between two voids (ICI, n = 32). RESULTS: LPP was significantly elevated in the GPS group (mean ± SD: 110.9 ± 6.2 mmHg) compared to the NC (81.0 ± 32.5 mmHg), PS (40.3 ± 10.9 mmHg), and NAC group (70.3 ± 19.4 mmHg). The cystometrogram data also reveals a prolonged ICI in the GPS group (241.3 ± 40.2 s) compared to the NC group (216.0 ± 41.7 s), PS group (128.8 ± 23.6 s), and NAC group (193.8 ± 28.3 s). CONCLUSION: This preliminary study implies the ameliorative impact of GPS treatment on OAB in terms of improved urodynamic parameters, including LPP and ICI.

Social mindfulness and prosociality vary across the globe.

Humans are social animals, but not everyone will be mindful of others to the same extent. Individual differences have been found, but would social mindfulness also be shaped by one's location in the world? Expecting cross-national differences to exist, we examined if and how social mindfulness differs across countries. At little to no material cost, social mindfulness typically entails small acts of attention or kindness. Even though fairly common, such low-cost cooperation has received little empirical attention. Measuring social mindfulness across 31 samples from industrialized countries and regions (n = 8,354), we found considerable variation. Among selected country-level variables, greater social mindfulness was most strongly associated with countries' better general performance on environmental protection. Together, our findings contribute to the literature on prosociality by targeting the kind of everyday cooperation that is more focused on communicating benevolence than on providing material benefits.

Bidirectional Longitudinal Associations between Parental Psychological Control and Peer Victimization among Chinese Adolescents: The Mediating Role of Basic Psychological Need Satisfaction.

Despite evidence indicating a connection between inappropriate parenting styles and peer victimization, the dynamic processes and mechanisms underlying this link and whether it is consistent across genders and different developmental stages have yet to be explored. To address these gaps, the current 2-year longitudinal study explored the potential bidirectional associations between parental psychological control and peer victimization, as well as the mediating role of adolescent basic psychological need satisfaction. A total of 4,990 adolescents (49.4% boys, Mage T1 = 12.21 years, SDage T1 = 2.60) across different developmental stages (early adolescents, N = 1,819, 49.2% boys, Mage T1 = 9.34 years, SDage T1 = 0.62; middle adolescents, N = 1,525, 50.75% boys, Mage T1 = 12.47 years, SDage T1 = 0.69; late adolescents, N = 1,646, 46.5% boys, Mage T1 = 15.26 years, SDage T1 = 0.50) participated in this three-wave longitudinal survey. The results revealed that parental psychological control was bidirectionally associated with peer victimization. Additionally, basic psychological need satisfaction played the meditating role in this vicious cycle. Further analysis demonstrated interesting developmental differences. Parental psychological control was directly associated with subsequent peer victimization at all three developmental stages, and peer victimization was only directly associated with subsequent parental psychological control in the next year among early adolescents and middle adolescents. The mutual mediating role of basic psychological need satisfaction between parental psychological control and peer victimization was observed exclusively in early adolescents. Both male and female adolescents could be equally affected by these dynamics. This research underscores the reciprocal dynamics inherent in parent-child interactions, intervening in either of these processes (i.e., family, peers, and adolescent basic psychological need satisfaction) may break this destructive cycle.

Color 3D display and security via monochrome scenes.

Color three-dimensional (3D) displays have always been the ideal display method because of their strong sense of reality, whereas color 3D displays of monochrome scenes are still challenging and unexplored. A color stereo reconstruction algorithm (CSRA) is proposed to solve the issue. We design a deep learning-based color stereo estimation (CSE) network to obtain color 3D information of monochrome scenes. The vivid color 3D visual effect is verified by our self-made display system. Furthermore, an efficient CSRA-based 3D image encryption scheme is achieved by encrypting a monochrome image with two-dimensional double cellular automata (2D-DCA). The proposed encryption scheme fulfills the requirement for real-time and high-security 3D image encryption with a large key space and the parallel processing capability of 2D-DCA.

3D salient object detection based on light field integral imaging.

Potent usage of the multi-scale light field information for salient object detection (SOD) is the essential requirement of three-dimensional (3D) SOD. On this basis, a light field 3D-SOD scheme is proposed that employs the pixel mapping algorithm to achieve a more distinct representation of spatial and angular information in the four-dimensional (4D) light field, collaboratively mining the global saliency cues via the co-salient object detection (CoSOD) network. Compared with the previous method, our scheme filters out most of the noise by thoroughly leveraging the global dependence of the 4D light field, offering significant enhancements in saliency extraction performance and efficiency. Additionally, the 3D reconstruction results demonstrate the integral retention of the spatial and angular information of the original light field.

Development of beliefs in a just world among Chinese early adolescents and the predictive role of family factors: A three-wave longitudinal study.

OBJECTIVE: This study explored how belief in a just world (BJW) develops among Chinese adolescents and the predictive role of family factors. BACKGROUND: The development of BJW in adolescence is an important but understudied topic, especially in non-Western contexts. METHOD: Using a three-wave longitudinal design, 1525 participants (48% girls; Mage = 12.47) were recruited to report their BJW, childhood SES, only-child or not, and parental psychological control in Wave 1 (Wave 2: N = 1262; Wave 3: N = 1124). RESULTS: The mean slope for personal BJW is positive and significant, but not significant for general BJW. Childhood SES predicted initial level of personal and general BJW and the rate of growth of personal BJW. Only-child predicted initial level and the growth rate of personal BJW. Parental psychological control negatively predicted personal and general BJW at three time points. CONCLUSION: Personal BJW increased during the observation period, whereas general BJW was stable. Individuals with lower levels of childhood SES had lower initial personal and general BJW but a higher growth rate in personal BJW than those with higher SES. Individuals having siblings had lower levels of initial personal BJW but a higher growth rate in personal BJW than those from only-child family. Parental psychological control may exert consistent and contemporaneous negative effect on BJW across time.

Effect of economic inequality on generosity: A social norm perspective.

Economic inequality has been found to reduce individuals' generosity in western contexts. However, whether this effect is cross-culturally consistent and its internal mechanism remain unclear, as well as how to mitigate this impact. Hence, we explored whether and why economic inequality may erode generosity in a sample of Chinese adults from the social norm perspective and introduced the equal allocation norm to mitigate this effect. Four online studies were conducted: two were correlational (Study 1: n = 300; Study 2: n = 568) and two were experimental (Study 3: n = 289; Study 4: n = 500). Results showed that economic inequality predicted less generosity in the dictator game, and perceived unequal allocation norm accounted for this effect. Moreover, introducing the equal allocation norm could buffer this negative effect. Findings suggest economic inequality impairs generosity, and making the equal allocation norm more salient may guide people to act more generously.

Prognostic value and predictive biomarkers of phenotypes of tumour-associated macrophages in colorectal cancer.

BACKGROUND: The roles of different subtypes of tumour-associated macrophages (TAMs) in predicting the prognosis of colorectal cancer (CRC) remain controversial. In this study, different subtypes of TAMs were investigated as prognostic and predictive biomarkers for CRC. METHODS: Expressions of CD68, CD86 and CD163 were investigated by immunohistochemistry (IHC) and immunofluorescence (IF), and the correlation between the expression of CD86 and CD163 was calculated in colorectal cancer tissues from 64 CRC patients. RESULTS: The results showed that high expressions of CD86+ and CD68+ CD86+ TAMs as well as low expression of CD163+ and CD68+ CD163+ TAMs were significantly associated with favourable overall survival (OS). The level of CD86 protein expression showed a negative correlation with CD163 protein expression. In addition, CD86 protein expression remarkably negatively correlated with tumour differentiation and tumour node metastasis (TNM) stage, while CD163 protein expression significantly positively correlated with tumour differentiation and tumour size. As an independent risk factor, high expression of CD86 TAMs had prominently favourable prognostic efficacy, while high expression of CD68+ CD163+ TAMs had significantly poor prognostic efficacy. CONCLUSIONS: These results indicate that CD86+ and CD68+ CD163+ TAMs as prognostic and predictive biomarkers for CRC.

[Mechanism of lung and intestine combination therapy in treatment of acute lung injury by inhibiting inflammatory response based on NF-κB/NLRP3 signaling pathway and alveolar macrophage activation].

Lung and intestine combination therapy(LICT) is effective in the treatment of acute lung injury(ALI). In this study, the combination of Mahuang Decoction and Dachengqi Decoction(hereinafter referred to as the combination), a manifestation of LICT, was employed to explore the effect of nuclear factor kappaB(NF-κB)/nucleotide binding oligomerization domain-like receptors-3(NLRP3) pathway and alveolar macrophage activation on the lung inflammation in rats with ALI, for the purpose of elucidating the mechanism of LICT in treating ALI. After the modeling of ALI with limpolysaccharide(LPS, ip), rats were respectively given(ig) the combination at 10, 7.5, and 5 g·kg~(-1)(high-dose, medium-dose, and low-dose LICT groups, separately), once every 8 h for 3 times. Haematoxylin-eosin(HE) staining was used to observe the histopathological changes of lung tissue, followed by the scoring of inflammation. Immunohistochemistry was applied to detect alveolar macrophage activation, enzyme-linked immunosorbent assay(ELISA) was applied to detect the serum content of tumor necrosis factor-α(TNF-α) and interleukin-18(IL-18), Western blot was applied to detect the protein expression of phosphorylated-nuclear factor kappaB p65(p-NF-κB p65), nuclear factor kappaB p65(NF-κB p65), phosphorylated-inhibitor kappaB alpha(p-IκBα), inhibitor kappaB alpha(IκBα), and NLRP3 in lung tissue, and quantitative reverse transcription-PCR(qRT-PCR) was applied to detect the mRNA expression of TNF-α, IL-18, NLRP3, and NF-κB p65 in lung tissue. The results showed that LICT groups demonstrated lung injury relief, decrease in inflammation score, alleviation of alveolar macrophage activation, significant decline in serum content of inflammatory factors TNF-α and IL-18, and decrease of the protein expression of p-NF-κB p65/NF-κB p65, p-IκBα/IκBα, and NLRP3, and mRNA expression of TNF-α, IL-18, NLRP3, and NF-κB p65 in lung tissue. In summary, LICT has definite therapeutic effect on ALI. The mechanism is that it inhibits alveolar macrophage activation by suppressing NF-κB/NLRP3 signaling pathway, thereby reducing the activation and release of inflammatory factors and finally inhibiting inflammation.

Honesty-Humility and unethical behavior in adolescents: The mediating role of moral disengagement and the moderating role of system justification.

INTRODUCTION: Honesty-Humility represents the tendency to be fair, genuine, and cooperative in social interactions. Although previous evidence has demonstrated that Honesty-Humility is related to decreased unethical behavior, little is known about the mediating and moderating mechanisms underlying this relationship, especially among adolescents. Based on social cognitive theory and system justification theory, the present study aims to examine the mediating role of moral disengagement and the moderating role of system justification in the relationship between Honesty-Humility and unethical behavior among Chinese adolescents. METHODS: A large sample of Chinese adolescents (N = 2,576, 47% boys; Mage = 17.00 years, SD = 1.07) was recruited from four senior high schools. The participants completed questionnaires regarding Honesty-Humility, moral disengagement, system justification, and unethical behavior. RESULTS: The findings suggested that Honesty-Humility was negatively associated with adolescents' unethical behavior, and moral disengagement partially mediated this negative association. Furthermore, system justification moderated the mediation model. Specifically, the negative relationships between Honesty-Humility and moral disengagement/unethical behavior were stronger among adolescents who perceive the society as fair. CONCLUSION: These findings advance the understanding of when and how Honesty-Humility prevents adolescents from unethical behavior. The theoretical and practical implications of the current study as well as future research directions are discussed.

Role of TRPA1 in Tissue Damage and Kidney Disease.

TRPA1, a nonselective cation channel, is expressed in sensory afferent that innervates peripheral targets. Neuronal TRPA1 can promote tissue repair, remove harmful stimuli and induce protective responses via the release of neuropeptides after the activation of the channel by chemical, exogenous, or endogenous irritants in the injured tissue. However, chronic inflammation after repeated noxious stimuli may result in the development of several diseases. In addition to sensory neurons, TRPA1, activated by inflammatory agents from some non-neuronal cells in the injured area or disease, might promote or protect disease progression. Therefore, TRPA1 works as a molecular sentinel of tissue damage or as an inflammation gatekeeper. Most kidney damage cases are associated with inflammation. In this review, we summarised the role of TRPA1 in neurogenic or non-neurogenic inflammation and in kidney disease, especially the non-neuronal TRPA1. In in vivo animal studies, TRPA1 prevented sepsis-induced or Ang-II-induced and ischemia-reperfusion renal injury by maintaining mitochondrial haemostasis or via the downregulation of macrophage-mediated inflammation, respectively. Renal tubular epithelial TRPA1 acts as an oxidative stress sensor to mediate hypoxia-reoxygenation injury in vitro and ischaemia-reperfusion-induced kidney injury in vivo through MAPKs/NF-kB signalling. Acute kidney injury (AKI) patients with high renal tubular TRPA1 expression had low complete renal function recovery. In renal disease, TPRA1 plays different roles in different cell types accordingly. These findings depict the important role of TRPA1 and warrant further investigation.

Renal Tubular Epithelial TRPA1 Acts as An Oxidative Stress Sensor to Mediate Ischemia-Reperfusion-Induced Kidney Injury through MAPKs/NF-κB Signaling.

Oxidative stress and inflammation play important roles in the pathophysiology of acute kidney injury (AKI). Transient receptor potential ankyrin 1 (TRPA1) is a Ca2+-permeable ion channel that is sensitive to reactive oxygen species (ROS). The role of TRPA1 in AKI remains unclear. In this study, we used human and animal studies to assess the role of renal TRPA1 in AKI and to explore the regulatory mechanism of renal TRPA1 in inflammation via in vitro experiments. TRPA1 expression increased in the renal tubular epithelia of patients with AKI. The severity of tubular injury correlated well with tubular TRPA1 or 8-hydroxy-2'-deoxyguanosine expression. In an animal model, renal ischemia-reperfusion injury (IR) increased tubular TRPA1 expression in wild-type (WT) mice. Trpa1-/- mice displayed less IR-induced tubular injury, oxidative stress, inflammation, and dysfunction in kidneys compared with WT mice. In the in vitro model, TRPA1 expression increased in renal tubular cells under hypoxia-reoxygenation injury (H/R) conditions. We demonstrated that H/R evoked a ROS-dependent TRPA1 activation, which elevated intracellular Ca2+ level, increased NADPH oxidase activity, activated MAPK/NF-κB signaling, and increased IL-8. Renal tubular TRPA1 may serve as an oxidative stress sensor and a crucial regulator in the activation of signaling pathways and promote the subsequent transcriptional regulation of IL-8. These actions might be evident in mice with IR or patients with AKI.

TLC388 Induces DNA Damage and G2 Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells.

TLC388, a camptothecin-derivative targeting topoisomerase I, is a potential anticancer drug. In this study, its effect on A549 and H838 human non-small cell lung cancer (NSCLC) cells was investigated. Cell viability and proliferation were determined by thiazolyl blue tetrazolium bromide and clonogenic assays, respectively, and cell cycle analysis and detection of phosphorylated histone H3 (Ser10) were performed by flow cytometry. γ-H2AX protein; G2/M phase-associated molecules ataxia-telangiectasia mutated (ATM), CHK1, CHK2, CDC25C, CDC2, and cyclin B1; and apoptosis were assessed with immunofluorescence staining, immunoblotting, and an annexin V assay, respectively. The effect of co-treatment with CHIR124 (a checkpoint kinase 1 [CHK1] inhibitor) was also studied. TLC388 decreased the viability and proliferation of cells of both NSCLC lines in a dose-dependent manner. TLC388 inhibited the viability of NSCLC cell lines with an estimated concentration of 50% inhibition (IC50), which was 4.4 and 4.1 µM for A549 and H838 cells, respectively, after 24 hours. Moreover, it resulted in the accumulation of cells at the G2/M phase and increased γ-H2AX levels in A549 cells. Levels of the G2 phase-related molecules phosphorylated ATM, CHK1, CHK2, CDC25C, and cyclin B1 were increased in TLC388-treated cells. CHIR124 enhanced the cytotoxicity of TLC388 toward A549 and H838 cells and induced apoptosis of the former. TLC388 inhibits NSCLC cell growth by inflicting DNA damage and activating G2/M checkpoint proteins that trigger G2 phase cell cycle arrest to enable DNA repair. CHIR124 enhanced the cytotoxic effect of TLC388 and induced apoptosis.

Opposite effects of statins on the risk of tuberculosis and herpes zoster in patients with diabetes: A population-based cohort study.

It remains uncertain whether statin use is associated with the risks of tuberculosis (TB) and herpes zoster in patients with type 2 diabetes. This study aims to assess the effects of statins vs nonstatin lipid-lowering agents on the risk of these infectious diseases in patients with diabetes. METHODS: Participants in the Taiwan National Health Insurance Research Database diagnosed with type 2 diabetes in 2001-2013 were classified as statin users, nonstatin users and lipid-lowering drug-free groups. Participants were observed for incident TB and herpes zoster from diabetes diagnosis until treatment crossover or December 2013. Statin user and nonstatin user were the time-dependent variables in Cox regression analysis. RESULTS: Over 240 782 person-years of observation, statin users (n = 17 696) were associated with a lower TB risk than nonstatin users (n = 5327) and the drug-free group (n = 22 316) (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.44-0.99 and aHR: 0.57; 95% CI: 0.44-0.73). Compared with nonstatin users, statin users showed a dose-dependent association with TB risk (low-potency statin users, aHR: 0.692; 95% CI: 0.455-1.053; high-potency users, aHR: 0.491; 95% CI: 0.241-0.999). Statin users presented with a higher risk of herpes zoster than nonstatin users and the drug-free group (aHR: 1.23; 95% CI: 1.01-1.50 and aHR: 1.20; 95% CI: 1.09-1.33). The risks of TB and herpes zoster were not statistically different between nonstatin users and the drug-free group. CONCLUSION: Compared with nonstatin drugs, statin use was specifically associated with a decreased risk of TB but a moderately increased risk of herpes zoster in this cohort study.

Chinese adolescents with higher social dominance orientation are less prosocial and less happy: A value-environment fit analysis.

This study aims to investigate the relationship between social dominance orientation (SDO) and subjective well-being among Chinese adolescents (N = 4246), and to examine the mediating role of prosocial behaviour in this relationship. The structural equation model's results showed that SDO was negatively associated with prosocial behaviour and subjective well-being, that prosocial behaviour was positively associated with subjective well-being, and also that (low) prosocial behaviour partially mediated the negative relationship between SDO and subjective well-being. Multi-group analyses showed that the mediation model was generally similar between boys and girls, but that the negative relationship between SDO and prosocial behaviour was somewhat stronger among girls than boys. This study sheds light on how SDO is associated with positive outcomes among Chinese adolescents and highlights the mediating role of prosocial behaviour as an underlying mechanism between SDO and subjective well-being. Future studies are needed to further discover the role of culture values in the association between SDO and subjective well-being.

Size Regulation of Platinum Nanoparticles by Using Confined Spaces for the Low-Temperature Oxidation of Ethylene.

Noble-metal nanoparticles have attracted great attention because of their excellent catalytic activity. However, the activity of noble-metal nanoparticles is severely dependent on the size of the metal nanoparticles. Therefore, regulation of the nanoparticle size is of great importance. Herein we report an efficient strategy for the first time to regulate the size of platinum (Pt) nanoparticles in a typical mesoporous silica SBA-15 by using the confined spaces. The Pt-containing precursor is introduced to the confined spaces between the template and silica walls in as-prepared SBA-15 by grinding. Subsequent calcination allows template removal and precursor conversion in one step and avoids repeated calcination in conventional modification processes. This leads to the formation of Pt nanoparticles with smaller size, making Pt metal catalysts highly active. Hence, the catalytic activity of the oxidation of trace ethylene is very superior to that of those prepared by the conventional method. For a typical material, PtAS-5, containing 5.0 wt % Pt, the complete conversion of ethylene was achieved at 40 °C, which is lower than that on the catalyst PtCS-5 prepared by the conventional method (50 °C) as well as that on a series of catalysts reported previously.

Three good deeds and three blessings: The kindness and gratitude interventions with Chinese prisoners.

BACKGROUND: Studies have found lower well-being among prisoners than in the general population. Positive psychological interventions provide fruitful ways of enhancing people's well-being, but little is known about whether these contribute to prisoners' well-being. AIMS: To test the effects of two typical positive psychological interventions - kindness and gratitude - on Chinese prisoners' well-being. METHODS: One hundred and forty-four participants were randomly assigned to three conditions: kindness or gratitude groups in addition to 'treatment as usual' and a control condition of treatment as usual alone, with 48 men in each condition. Participants completed established well-being measures before and after the 6-week intervention and a similar period in control conditions. RESULTS: Both kindness and gratitude interventions significantly increased prisoners' well-being compared to the control group. The kindness intervention promoted higher well-being than the gratitude intervention. CONCLUSIONS: Although both kindness and gratitude interventions enhanced prisoners' happiness and mitigated negative affect, the weaker effect of the gratitude condition reflects Chinese strongly communal culture, so further cross-cultural studies would be of interest. Future research should also include longer term follow-up and expand the work to include women in prison.