Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells.
J Biol Chem
; 298(5): 101890, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378132
3.
Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents.
Bioorg Med Chem Lett
; 65: 128713, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367592
4.
CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.
Mol Pharmacol
; 96(4): 419-429, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467029
5.
Selective degradation of CDK6 by a palbociclib based PROTAC.
Bioorg Med Chem Lett
; 29(11): 1375-1379, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935795
6.
Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA.
RSC Chem Biol
; 3(1): 32-36, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128406
7.
Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.
Chem Biol Drug Des
; 96(2): 773-784, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32237047
8.
Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.
Oncotarget
; 11(25): 2462-2463, 2020 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32637035
9.
Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.
ACS Chem Biol
; 13(5): 1148-1152, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29608269
10.
Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.
Oncotarget
; 9(4): 5216-5232, 2018 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29435174
11.
Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
Chem Commun (Camb)
; 53(54): 7577-7580, 2017 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636052
12.
Long-circulatory nanoparticles for gemcitabine delivery: Development and investigation of pharmacokinetics and in-vivo anticancer efficacy.
Eur J Pharm Sci
; 92: 183-93, 2016 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27404580
13.
Development and evaluation of paclitaxel loaded PLGA:poloxamer blend nanoparticles for cancer chemotherapy.
Int J Biol Macromol
; 69: 393-9, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24942992
14.
Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate.
Int J Pharm
; 470(1-2): 51-62, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24810239
15.
Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines.
Eur J Med Chem
; 70: 864-74, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24262379