Detalhe da pesquisa
1.
Population pharmacokinetic analysis of RO5459072, a low water-soluble drug exhibiting complex food-drug interactions.
Br J Clin Pharmacol
; 87(9): 3550-3560, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33576513
2.
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
J Pharmacol Exp Ther
; 365(2): 237-248, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453199
3.
Functional analysis and transcriptional output of the Göttingen minipig genome.
BMC Genomics
; 16: 932, 2015 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26573612
4.
Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
Bioorg Med Chem Lett
; 20(18): 5426-30, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20724150
5.
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.
Sci Rep
; 9(1): 4074, 2019 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858459
6.
Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.
PLoS One
; 13(10): e0205435, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30332475
7.
The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.
BMC Struct Biol
; 7: 66, 2007 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17935609
8.
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
AAPS J
; 19(2): 534-550, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28050713
9.
Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.
ChemMedChem
; 11(19): 2216-2239, 2016 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27629993
10.
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
J Med Chem
; 58(22): 9041-60, 2015 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26523333
11.
Predicting plasma protein binding of drugs--revisited.
Curr Opin Drug Discov Devel
; 7(4): 507-12, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15338960
12.
Predicting plasma protein binding of drugs: a new approach.
Biochem Pharmacol
; 64(9): 1355-74, 2002 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12392818
13.
Nucleotide Platination Induced by Visible Light.
Angew Chem Int Ed Engl
; 38(10): 1460-1463, 1999 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711587
14.
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
Curr Top Med Chem
; 11(15): 1902-24, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21470172
15.
Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes.
Angew Chem Int Ed Engl
; 42(3): 335-9, 2003 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12548693
16.
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.
Genomics
; 85(3): 372-85, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15718104
17.
An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application.
J Chem Inf Model
; 45(5): 1324-36, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16180909