Detalhe da pesquisa
1.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26669328
2.
Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development.
Regul Toxicol Pharmacol
; 73(2): 562-70, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26382609
3.
Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
Bioorg Med Chem Lett
; 24(17): 4187-91, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25091930
4.
Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys.
PLoS One
; 19(2): e0298240, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38315680
5.
Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper.
Drug Metab Dispos
; 41(9): 1598-609, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23792813
6.
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Proc Natl Acad Sci U S A
; 107(20): 9446-51, 2010 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439741
7.
A model-based approach to predicting the human pharmacokinetics of a monoclonal antibody exhibiting target-mediated drug disposition.
J Pharmacol Exp Ther
; 341(3): 702-8, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22414855
8.
Identification and quantification of osteopontin splice variants in the plasma of lung cancer patients using immunoaffinity capture and targeted mass spectrometry.
Biomarkers
; 17(2): 125-33, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22188260
9.
How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.
Drug Metab Dispos
; 39(10): 1779-83, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21768274
10.
An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
Cancer Immunol Res
; 9(10): 1141-1157, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34376502
11.
Structure-based design of novel human Pin1 inhibitors (II).
Bioorg Med Chem Lett
; 20(7): 2210-4, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207139
12.
Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody.
Mol Cancer Ther
; 19(10): 2105-2116, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32847983
13.
Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.
Mol Cancer Ther
; 7(8): 2394-404, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18723486
14.
Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics.
J Immunother Cancer
; 7(1): 105, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30992085
15.
Author Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer.
Sci Rep
; 9(1): 16735, 2019 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31700121
16.
Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer.
Sci Rep
; 9(1): 8420, 2019 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182754
17.
Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.
J Med Chem
; 49(11): 3362-7, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16722655
18.
Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys.
Cytometry B Clin Cytom
; 90(2): 191-8, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25914284
19.
RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models.
Mol Cancer Ther
; 15(11): 2698-2708, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582525
20.
Modeling, simulation, and translation framework for the preclinical development of monoclonal antibodies.
AAPS J
; 15(2): 551-8, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408094