Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 181(6): 1291-1306.e19, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32407674

2.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Gehart, Helmuth; van Es, Johan H; Hamer, Karien; Beumer, Joep; Kretzschmar, Kai; Dekkers, Johanna F; Rios, Anne; Clevers, Hans.

Cell ; 176(5): 1158-1173.e16, 2019 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-30712869

3.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 182(4): 1062-1064, 2020 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-32822568

4.

Lineage tracing.

Kretzschmar, Kai; Watt, Fiona M.

Cell ; 148(1-2): 33-45, 2012 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-22265400

5.

Modelling adult stem cells and their niche in health and disease with epithelial organoids.

Szabó, Lili; Seubert, Anna C; Kretzschmar, Kai.

Semin Cell Dev Biol ; 144: 20-30, 2023 07 30.

Artigo em Inglês | MEDLINE | ID: mdl-36127261

6.

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.

Boonekamp, Kim E; Kretzschmar, Kai; Wiener, Dominique J; Asra, Priyanca; Derakhshan, Sepideh; Puschhof, Jens; López-Iglesias, Carmen; Peters, Peter J; Basak, Onur; Clevers, Hans.

Proc Natl Acad Sci U S A ; 116(29): 14630-14638, 2019 07 16.

Artigo em Inglês | MEDLINE | ID: mdl-31253707

7.

Profiling proliferative cells and their progeny in damaged murine hearts.

Kretzschmar, Kai; Post, Yorick; Bannier-Hélaouët, Marie; Mattiotti, Andrea; Drost, Jarno; Basak, Onur; Li, Vivian S W; van den Born, Maaike; Gunst, Quinn D; Versteeg, Danielle; Kooijman, Lieneke; van der Elst, Stefan; van Es, Johan H; van Rooij, Eva; van den Hoff, Maurice J B; Clevers, Hans.

Proc Natl Acad Sci U S A ; 115(52): E12245-E12254, 2018 12 26.

Artigo em Inglês | MEDLINE | ID: mdl-30530645

8.

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.

Karmouch, Jennifer; Zhou, Qiong Q; Miyake, Christina Y; Lombardi, Raffaella; Kretzschmar, Kai; Bannier-Hélaouët, Marie; Clevers, Hans; Wehrens, Xander H T; Willerson, James T; Marian, Ali J.

Circ Res ; 121(12): 1346-1359, 2017 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-29018034

9.

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Driskell, Ryan R; Lichtenberger, Beate M; Hoste, Esther; Kretzschmar, Kai; Simons, Ben D; Charalambous, Marika; Ferron, Sacri R; Herault, Yann; Pavlovic, Guillaume; Ferguson-Smith, Anne C; Watt, Fiona M.

Nature ; 504(7479): 277-281, 2013 Dec 12.

Artigo em Inglês | MEDLINE | ID: mdl-24336287

10.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Tetteh, Paul W; Kretzschmar, Kai; Begthel, Harry; van den Born, Maaike; Korving, Jeroen; Morsink, Folkert; Farin, Henner; van Es, Johan H; Offerhaus, G Johan A; Clevers, Hans.

Proc Natl Acad Sci U S A ; 113(42): 11859-11864, 2016 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-27708166

11.

Wnt/ß-catenin signaling in adult mammalian epithelial stem cells.

Kretzschmar, Kai; Clevers, Hans.

Dev Biol ; 428(2): 273-282, 2017 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-28526587

12.

Establishment and characterization of a canine keratinocyte organoid culture system.

Wiener, Dominique J; Basak, Onur; Asra, Priyanca; Boonekamp, Kim E; Kretzschmar, Kai; Papaspyropoulos, Angelos; Clevers, Hans.

Vet Dermatol ; 29(5): 375-e126, 2018 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-29963730

13.

Everything has its time: Id2 clocks embryonic specification of Lgr5⁺ gut stem cells.

Kretzschmar, Kai; Clevers, Hans.

EMBO J ; 36(7): 837-839, 2017 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-28298434

14.

Sox2 modulates the function of two distinct cell lineages in mouse skin.

Lesko, Marta H; Driskell, Ryan R; Kretzschmar, Kai; Goldie, Stephen J; Watt, Fiona M.

Dev Biol ; 382(1): 15-26, 2013 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-23948231

15.

Reprogramming adult dermis to a neonatal state through epidermal activation of ß-catenin.

Collins, Charlotte A; Kretzschmar, Kai; Watt, Fiona M.

Development ; 138(23): 5189-99, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-22031549

16.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models.

Xiang, Kun; Wang, Ergang; Mantyh, John; Rupprecht, Gabrielle; Negrete, Marcos; Sanati, Golshid; Hsu, Carolyn; Randon, Peggy; Dohlman, Anders; Kretzschmar, Kai; Bose, Shree; Giroux, Nicholas; Ding, Shengli; Wang, Lihua; Balcazar, Jorge Prado; Huang, Qiang; Sundaramoorthy, Pasupathi; Xi, Rui; McCall, Shannon Jones; Wang, Zhaohui; Jiang, Chongming; Kang, Yubin; Kopetz, Scott; Crawford, Gregory E; Lipkin, Steven M; Wang, Xiao-Fan; Clevers, Hans; Hsu, David; Shen, Xiling.

Adv Sci (Weinh) ; 11(16): e2303379, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38380561

17.

Human organoids are superior to cell culture models for intestinal barrier research.

Kollmann, Catherine; Buerkert, Hannah; Meir, Michael; Richter, Konstantin; Kretzschmar, Kai; Flemming, Sven; Kelm, Matthias; Germer, Christoph-Thomas; Otto, Christoph; Burkard, Natalie; Schlegel, Nicolas.

Front Cell Dev Biol ; 11: 1223032, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37849736

18.

Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures.

Yang, Annie S P; Dutta, Devanjali; Kretzschmar, Kai; Hendriks, Delilah; Puschhof, Jens; Hu, Huili; Boonekamp, Kim E; van Waardenburg, Youri; Chuva de Sousa Lopes, Susana M; van Gemert, Geert-Jan; de Wilt, Johannes H W; Bousema, Teun; Clevers, Hans; Sauerwein, Robert W.

Nat Commun ; 14(1): 4631, 2023 08 02.

Artigo em Inglês | MEDLINE | ID: mdl-37532704

19.

Uncovering the mode of action of engineered T cells in patient cancer organoids.

Dekkers, Johanna F; Alieva, Maria; Cleven, Astrid; Keramati, Farid; Wezenaar, Amber K L; van Vliet, Esmée J; Puschhof, Jens; Brazda, Peter; Johanna, Inez; Meringa, Angelo D; Rebel, Heggert G; Buchholz, Maj-Britt; Barrera Román, Mario; Zeeman, Amber L; de Blank, Sam; Fasci, Domenico; Geurts, Maarten H; Cornel, Annelisa M; Driehuis, Else; Millen, Rosemary; Straetemans, Trudy; Nicolasen, Mara J T; Aarts-Riemens, Tineke; Ariese, Hendrikus C R; Johnson, Hannah R; van Ineveld, Ravian L; Karaiskaki, Froso; Kopper, Oded; Bar-Ephraim, Yotam E; Kretzschmar, Kai; Eggermont, Alexander M M; Nierkens, Stefan; Wehrens, Ellen J; Stunnenberg, Henk G; Clevers, Hans; Kuball, Jürgen; Sebestyen, Zsolt; Rios, Anne C.

Nat Biotechnol ; 41(1): 60-69, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-35879361

20.

Cancer research using organoid technology.

Kretzschmar, Kai.

J Mol Med (Berl) ; 99(4): 501-515, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33057820

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High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Lineage tracing.

Modelling adult stem cells and their niche in health and disease with epithelial organoids.

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.

Profiling proliferative cells and their progeny in damaged murine hearts.

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Wnt/ß-catenin signaling in adult mammalian epithelial stem cells.

Establishment and characterization of a canine keratinocyte organoid culture system.

Everything has its time: Id2 clocks embryonic specification of Lgr5⁺ gut stem cells.

Sox2 modulates the function of two distinct cell lineages in mouse skin.

Reprogramming adult dermis to a neonatal state through epidermal activation of ß-catenin.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models.

Human organoids are superior to cell culture models for intestinal barrier research.

Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures.

Uncovering the mode of action of engineered T cells in patient cancer organoids.

Cancer research using organoid technology.