Detalhe da pesquisa
1.
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect.
PLoS Genet
; 17(1): e1009236, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465068
2.
Evolutionary Aspects of TRPMLs and TPCs.
Int J Mol Sci
; 21(11)2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32545371
3.
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Structure
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38815576
4.
Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction.
bioRxiv
; 2023 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873080
5.
P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2.
Cell Rep
; 42(12): 113501, 2023 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38039128
6.
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Cell Calcium
; 103: 102553, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35144097
7.
Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases.
Biomed Pharmacother
; 148: 112751, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35240524
8.
TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.
EMBO Mol Med
; 14(9): e15377, 2022 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35929194
9.
JPT2: The missing link between intracellular Ca2+ release channels and NAADP?
Cell Calcium
; 97: 102405, 2021 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33873071
10.
Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation.
Biochim Biophys Acta Mol Cell Res
; 1868(2): 118921, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33279607
11.
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
EMBO Mol Med
; 13(10): e13742, 2021 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34411438
12.
Discovery of lipophilic two-pore channel agonists.
FEBS J
; 287(24): 5284-5293, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32478984
13.
TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles.
Sci Adv
; 6(46)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177082
14.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Elife
; 92020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32167471
15.
The protein interaction networks of mucolipins and two-pore channels.
Biochim Biophys Acta Mol Cell Res
; 1866(7): 1111-1123, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30395881
16.
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.
Elife
; 72018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30479274