[INDICES OF THE OXIDATIVE STATUS IN CHRONIC ADMINISTRATION OF COLLOID CARBONATE CALCIUM PRAPARATION WITH FAUCET AND LOW-MINERALIZED DRINKING WATER IN RATS].

There are discussed the changes of an array of indices of the oxidative status in chronic administration of colloidal calcium carbonate preparation with faucet and low-mineralized drinking water to rats. Slight differences between significant effects of administration of 3 and 30 mg/L of preparation permit to suggest that the process of its incoming delivery into organism of rats has a bottleneck in the nature of total capacity of macrophages of intestinal lymphoid tissue to absorption of particles.

[Comparative analysis of the influence of nano- and ionic forms of silver on biochemical indices in laboratory animals].

A comparative analysis of the effect of silver nanoparticles (SNP) with a diameter of 14 nm and silver sulfate (SS) on biochemical indices of the state of the organism under the administration of preparations with drinking water to mice F1 CBAxC57Bl (from 0.1 to 500 mg Ag/l for 2 weeks) and nonlinear rats (from 0.01 to 5 mg Ag/l within 6 months) has been performed In the experiment on mice there was found an increase in activity of glutathione reductase (GR) in erythrocytes under the administration of both drugs and reduction of antiradical activity of serum--under the introduction of SNP only. The administration of low doses of SNP in the experiment on rats caused much less pronounced changes in serum markers of the state of the liver; kidneys, protein and lipids metabolism in comparison with equivalent doses of the SS, that as a whole with the qualitative differences on GR activity in erythrocytes satisfactorily was explained by activation of phagocytic cells with nanoparticles. Thus, for the first time the SNP biological effects in animals were shown to be caused both by the exposure to solubilized Ag+ ions and by the response of cells to the surface of the nanoparticles themselves.

[Biochemical effects of chronic peroral administration of carbon nanotubes and activated charcoal in drinking water in rats].

Chronic 6-month experiment was carried out in rats, which received drinking water with multi-walled carbon nanotubes (MWCNTs), diameter of 15-40 nm, length ≥ 2 mkm) or activated charcoal (AC, diameter of 10-100 mkm), blood samples of the animals were used for assessment of biochemical markers. Both coal compounds induced the appearance of signs of oxidative stress 2 weeks after the beginning of the experiment and alteration of serum markers of liver and renal damage, as well as changes of cortisol and protein serum concentrations later Thus, despite of known high (asbest-like) inhalation toxicity of carbon nanotubes in comparison with other carbon allotrops (fullerenes and black carbon), we have found similar effects of MWCNTs and carbon microparticles in orally treated rats.

[Phenotypic polymorphism of biomedical parameters of the health status in hygienic studies].

The paper presents the results of investigating the phenotypic polymorphism of a number of biochemical and immunological parameters (the values of oxidative stress, the activity of catalase and glutathione-S-transferase in red blood cells, the serum levels of catecholamines, tumor-necrosis factor-?, and IgG antibody subclasses) in the authors' hygienic studies of genotypic and nongenotypic population samples.

[Spatial ultrasound visualization of the eye and orbit].

The paper presents data on the diagnostic use of three-dimensional (3-D) ultrasound visualization, analyzes earlier existing and new ultrasound diagnostic technologies, and shows it expedient to apply them in ophthalmologic practice. A hundred and forty-six healthy individuals and 52 patients (60 eyes) with different diseases of the eye and orbital cavity (chorioidal melanoma, facial angiomatosis, retinal detachment, vitreoretinal changes, etc.) were examined. The results of the studies and the analysis of the data available in the literature on this problem allow the authors to state that 3-D ultrasound diagnostic technologies can detect occult masses undetectable during conventional visual and ultrasound studies and define the topography of the dislocation of structurally complicated changes in the tunics of the eyeball.

[2. Diagnostic resources and clinical indications]. / Soobshchenie 2. Diagnosticheskie vozmozhnosti i klinicheskie pokazaniia.

Preliminary investigations, dedicated to the diagnostic application of three-dimension ultrasonic angioreconstruction, confirmed the feasibility of using the above method in ophthalmologic practice in cases of suspected intraocular and orbital neoplasms. 32 patients (37 eyes) with various pathologies of the eye and orbital cavity, including choroidal melanoma, facial angiomatosis, retinal detachment, chronic uveitis etc.) were examined. The results are indicative of that the three-dimension ultrasonic angioreconstruction makes it possible to detect the latent vascular neoplasms, which cannot be defined by the standard visual and ultrasonic examinations, and the dislocation of structural elements of the eyeball tunics. Besides, it provides for evaluating their special localization and their interrelations with the neighboring anatomic elements.

[Three-dimensional computerized sonography in evaluation of the vascular system of the eye and orbit. I. Methodological approach and principles of analysis of results]. / Trekhmernaia komp'iuternaia sonografiia v opredelenii sosudistoi sistemy glaza i orbity. Soobshchenie 1. Metodicheskii podkhod i printsipy analiza rezul'tatov issledovaniia.

An examination of 40 healthy persons (80 eyes) enabled a refinement and unification of the ultrasound techniques applicable to investigations of a. ophthalmica, a. and v. centralis retinae, a. ciliaris brevis et longae and of other orbital space vessels. Abilities of various regimes of computer-based sonography, in particular of color energy Doppler mapping, were determined in examinations of capillary choroidal plexuses and of optic-nerve portions neighboring directly on the eyeball. The possibilities of using the three-dimension ultrasound angioreconstruction in examinations of the ocular angioarchitectonics and of the retrobulbar space were evaluated.