1.
Angew Chem Int Ed Engl
; 51(28): 7035-40, 2012 Jul 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22689512
RESUMO
High profile: new activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.