RESUMO
AIM: To determine the feasibility of semi-quantitative haemodynamic parameters derived from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to assess liver fibrosis. MATERIALS AND METHODS: Seventy-five patients with Child's A classification (males/females=24/51; average age, 58 years; range, 30-80 years) received DCE-MRI 3 days prior to hepatectomy. Semi-quantitative haemodynamic parameters, including the wash-in slope, wash-out slope, and time-to-peak, were calculated from DCE-MRI data. Liver fibrosis of the resected non-tumour liver was graded pathologically from F0 (no fibrosis) to F6 (cirrhosis) in the regions corresponding to those assessed by DCE-MRI. RESULTS: The wash-out slope showed higher interobserver and intra-observer reliabilities than the wash-in slope and time-to-peak. There was a significant positive correlation between the wash-out slope and pathological grade of fibrosis (Spearman's correlation coefficient: r=0.5331, p<0.0001). The area under the receiver operating characteristic curve was 0.8066 when using the wash-out slope to differentiate cirrhosis (grade F6) from non-cirrhosis (grades F0-5). Using the cut-off point that maximised specificity, the sensitivity was 62.07%, specificity was 91.30%, positive predictive value was 81.81%, negative predictive value was 79.25%, and accuracy was 80%. CONCLUSIONS: The wash-out slope derived from DCE-MRI might be potentially useful in assessing liver cirrhosis in patients with Child's A classification before hepatectomy.
Assuntos
Hepatectomia , Cirrose Hepática/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Meios de Contraste , Estudos de Viabilidade , Feminino , Humanos , Cirrose Hepática/cirurgia , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Cuidados Pré-Operatórios/métodosAssuntos
Vesícula/patologia , Exantema/patologia , Dermatose Linear Bolhosa por IgA/patologia , Idoso de 80 Anos ou mais , Antibacterianos/efeitos adversos , Betametasona/administração & dosagem , Betametasona/uso terapêutico , Vesícula/induzido quimicamente , Vesícula/tratamento farmacológico , Diagnóstico Diferencial , Exantema/induzido quimicamente , Glucocorticoides/uso terapêutico , Humanos , Imunoglobulina A/metabolismo , Dermatose Linear Bolhosa por IgA/induzido quimicamente , Dermatose Linear Bolhosa por IgA/diagnóstico , Dermatose Linear Bolhosa por IgA/tratamento farmacológico , Masculino , Combinação Piperacilina e Tazobactam/efeitos adversos , Prednisolona/administração & dosagem , Prednisolona/uso terapêutico , Resultado do Tratamento , Vancomicina/efeitos adversosAssuntos
Exantema/patologia , Púrpura/patologia , Rickettsia typhi/isolamento & purificação , Pele/patologia , Tifo Endêmico Transmitido por Pulgas/diagnóstico , Animais , Antibacterianos/uso terapêutico , Povo Asiático , Exantema/microbiologia , Febre/diagnóstico , Febre/etiologia , Técnica Indireta de Fluorescência para Anticorpo/métodos , Humanos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Masculino , Pessoa de Meia-Idade , Púrpura/microbiologia , Roedores , Pele/irrigação sanguínea , Resultado do Tratamento , Tifo Endêmico Transmitido por Pulgas/sangue , Tifo Endêmico Transmitido por Pulgas/tratamento farmacológicoRESUMO
The structure-activity relationships of 25 triorganotin(IV) compounds were studied using the 4th instar A. aegypti larvae of the susceptible Liverpool Red-eye strain. The LC50 values of these compounds were compared with those of Malathion, DDT and Temephos. Maximal activities were obtained with tritolyltin chloride and its complexes with triphenyl-phosphine oxide and pyridine N-oxide, dimethyloctyltin- and diethyloctyltin acetates and tributyltin sucrose phthalate. A limited number of the triorganotin compounds was also tested with observed high activity against the 4th instar larvae of a local DDT-tolerant strain and against the 2nd instar larvae and adults of the susceptible strain. Delayed effect studies with both 2nd and 4th instar larvae showed high post-treatment mortality for the latter and, among the range of active compounds, the methyl- and aryltin compounds, in particular, were also found to exhibit high residual activities (100% kill) in laboratory tests conducted up to 10 weeks.