1.
Arch Dermatol
; 112(8): 1158-60, 1976 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-182085
RESUMO
A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dose-dependent, but the mechanism by which it occurs is unknown.
Assuntos
Dapsona/efeitos adversos , Neurônios Motores , Doenças Neuromusculares/induzido quimicamente , Dermatopatias/tratamento farmacológico , Adulto , Dapsona/administração & dosagem , Relação Dose-Resposta a Droga , Feminino , Humanos , Degeneração Neural , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Prednisona/uso terapêutico , Dermatopatias/patologia , Sulfapiridina/uso terapêutico
2.
Conn Med
; 33(1): 29-36, 1969 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5762804