1.
Org Biomol Chem
; 6(23): 4315-8, 2008 Dec 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19005589
RESUMO
Polystyrene(40)-b-poly(isocyanoalanine(2-thiophen-3-yl-ethyl)amide)(50) (PS-PIAT) polymersomes have the unique property of being sufficiently porous to allow diffusion of small (organic) substrates while retaining large biomolecules such as enzymes inside. Herein we report on the encapsulation and protection of glucose oxidase (GOx) and horse radish peroxidase (HRP) in PS-PIAT polymersomes and the successful employment of these functionalised nanoreactors in a cascade reaction. The demonstrated concept allows for further application in other enzymatic cascade reactions, bio-organic hybrid systems and biosensing devices.
Assuntos
Alanina/análogos & derivados , Glucose Oxidase/metabolismo , Peroxidase do Rábano Silvestre/metabolismo , Iminas/química , Nanotecnologia , Poliestirenos/química , Alanina/química , Porosidade , Fatores de Tempo
2.
Angew Chem Int Ed Engl
; 46(39): 7378-82, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17705203