Detalhe da pesquisa
1.
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Chem Rev
; 121(6): 3238-3270, 2021 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410674
2.
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.
Bioorg Chem
; 131: 106269, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36446201
3.
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
J Biol Chem
; 297(2): 100909, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34171358
4.
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Biochemistry
; 60(39): 2925-2931, 2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34506130
5.
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning.
J Chem Inf Model
; 61(6): 2537-2541, 2021 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138546
6.
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Nucleic Acids Res
; 47(14): 7676-7689, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31424549
7.
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
J Virol
; 93(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381484
8.
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry
; 58(35): 3711-3726, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386353
9.
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
J Biomol NMR
; 73(6-7): 365-374, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243634
10.
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
J Chem Inf Model
; 59(9): 3679-3691, 2019 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381335
11.
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
Biochemistry
; 57(10): 1652-1662, 2018 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457713
12.
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
J Virol
; 91(10)2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28298600
13.
Introduction: Drug Resistance.
Chem Rev
; 121(6): 3235-3237, 2021 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33757288
14.
Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.
J Mol Recognit
; 30(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27859766
15.
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Proc Natl Acad Sci U S A
; 111(45): 15993-8, 2014 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355911
16.
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
J Am Chem Soc
; 138(36): 11850-9, 2016 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27512818
17.
HIV-1 protease-substrate coevolution in nelfinavir resistance.
J Virol
; 88(13): 7145-54, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24719428
18.
Burial of nonpolar surface area and thermodynamic stabilization of globins as a function of chain elongation.
Proteins
; 82(10): 2318-31, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752983
19.
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J Am Chem Soc
; 136(34): 11956-63, 2014 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25091085
20.
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.
ACS Infect Dis
; 10(4): 1174-1184, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38472113