Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells.

Brennecke, Philip; Reyes, Alejandro; Pinto, Sheena; Rattay, Kristin; Nguyen, Michelle; Küchler, Rita; Huber, Wolfgang; Kyewski, Bruno; Steinmetz, Lars M.

Nat Immunol ; 16(9): 933-41, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26237553

2.

Aire, master of many trades.

Kyewski, Bruno; Peterson, Pärt.

Cell ; 140(1): 24-6, 2010 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-20085700

3.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano, Tomoyoshi; Nedjic, Jelena; Hinterberger, Maria; Steinert, Madlen; Koser, Sandra; Pinto, Sheena; Gerdes, Norbert; Lutgens, Esther; Ishimaru, Naozumi; Busslinger, Meinrad; Brors, Benedikt; Kyewski, Bruno; Klein, Ludger.

Immunity ; 42(6): 1048-61, 2015 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-26070482

4.

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller, Corey N; Proekt, Irina; von Moltke, Jakob; Wells, Kristen L; Rajpurkar, Aparna R; Wang, Haiguang; Rattay, Kristin; Khan, Imran S; Metzger, Todd C; Pollack, Joshua L; Fries, Adam C; Lwin, Wint W; Wigton, Eric J; Parent, Audrey V; Kyewski, Bruno; Erle, David J; Hogquist, Kristin A; Steinmetz, Lars M; Locksley, Richard M; Anderson, Mark S.

Nature ; 559(7715): 627-631, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-30022164

5.

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Papadopoulou, Aikaterini S; Dooley, James; Linterman, Michelle A; Pierson, Wim; Ucar, Olga; Kyewski, Bruno; Zuklys, Saulius; Hollander, Georg A; Matthys, Patrick; Gray, Daniel H D; De Strooper, Bart; Liston, Adrian.

Nat Immunol ; 13(2): 181-7, 2011 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-22179202

6.

Love is in the Aire: mTECs share their assets.

Kyewski, Bruno; Feuerer, Markus.

Immunity ; 41(3): 343-345, 2014 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-25238088

7.

Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.

Ucar, Ahmet; Ucar, Olga; Klug, Paula; Matt, Sonja; Brunk, Fabian; Hofmann, Thomas G; Kyewski, Bruno.

Immunity ; 41(2): 257-69, 2014 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-25148026

8.

Re-examining the Nature and Function of Self-Reactive T cells.

Richards, David M; Kyewski, Bruno; Feuerer, Markus.

Trends Immunol ; 37(2): 114-125, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26795134

9.

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.

Michel, Chloé; Miller, Corey N; Küchler, Rita; Brors, Benedikt; Anderson, Mark S; Kyewski, Bruno; Pinto, Sheena.

J Immunol ; 199(10): 3488-3503, 2017 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-28993517

10.

Dissecting and modeling the emergent murine TEC compartment during ontogeny.

Brunk, Fabian; Michel, Chloé; Holland-Letz, Tim; Slynko, Alla; Kopp-Schneider, Annette; Kyewski, Bruno; Pinto, Sheena.

Eur J Immunol ; 47(7): 1153-1159, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28439878

11.

Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self-antigen in mice.

Lucca, Liliana E; Axisa, Pierre-Paul; Aloulou, Meryem; Perals, Corine; Ramadan, Abdulraouf; Rufas, Pierre; Kyewski, Bruno; Derbinski, Jens; Fazilleau, Nicolas; Mars, Lennart T; Liblau, Roland S.

Eur J Immunol ; 46(9): 2247-59, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27334749

12.

Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.

Brunk, Fabian; Augustin, Iris; Meister, Michael; Boutros, Michael; Kyewski, Bruno.

J Immunol ; 195(11): 5261-71, 2015 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-26512137

13.

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

Rattay, Kristin; Claude, Janine; Rezavandy, Esmail; Matt, Sonja; Hofmann, Thomas G; Kyewski, Bruno; Derbinski, Jens.

J Immunol ; 194(3): 921-8, 2015 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-25552543

14.

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

Rattay, Kristin; Meyer, Hannah Verena; Herrmann, Carl; Brors, Benedikt; Kyewski, Bruno.

J Autoimmun ; 67: 65-75, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26481130

15.

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.

Pinto, Sheena; Michel, Chloé; Schmidt-Glenewinkel, Hannah; Harder, Nathalie; Rohr, Karl; Wild, Stefan; Brors, Benedikt; Kyewski, Bruno.

Proc Natl Acad Sci U S A ; 110(37): E3497-505, 2013 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-23980163

16.

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

Pinto, Sheena; Sommermeyer, Daniel; Michel, Chloé; Wilde, Susanne; Schendel, Dolores; Uckert, Wolfgang; Blankenstein, Thomas; Kyewski, Bruno.

Eur J Immunol ; 44(9): 2811-21, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24846220

17.

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

Alvarez, Iñaki; Collado, Javier A; Colobran, Roger; Carrascal, Montserrat; Ciudad, M Teresa; Canals, Françesc; James, Eddie A; Kwok, William W; Gärtner, Martina; Kyewski, Bruno; Pujol-Borrell, Ricardo; Jaraquemada, Dolores.

J Autoimmun ; 60: 12-9, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25911201

18.

An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression.

Pinto, Sheena; Schmidt, Katrin; Egle, Stefanie; Stark, Hans-Jürgen; Boukamp, Petra; Kyewski, Bruno.

J Immunol ; 190(3): 1085-93, 2013 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-23269248

19.

Self-representation in the thymus: an extended view.

Kyewski, Bruno; Derbinski, Jens.

Nat Rev Immunol ; 4(9): 688-98, 2004 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-15343368

20.

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression.

Ucar, Olga; Tykocinski, Lars-Oliver; Dooley, James; Liston, Adrian; Kyewski, Bruno.

Eur J Immunol ; 43(7): 1769-78, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23589212

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