1.
J Org Chem
; 81(24): 12506-12513, 2016 12 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27978739
RESUMO
Polynitrogen heterocycles are often subject to Dimroth rearrangement which consists of ring opening, bond rotation, and ring closure. In this note, we report a synthesis of two new families of triazolopyridopyrimidines. Successful functionalization via a Suzuki-Miyaura coupling was performed with total control of triazole (Dimroth) isomerization based on the judicious choice of reaction conditions.