Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The multiple mechanisms that regulate p53 activity and cell fate.

Hafner, Antonina; Bulyk, Martha L; Jambhekar, Ashwini; Lahav, Galit.

Nat Rev Mol Cell Biol ; 20(4): 199-210, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30824861

2.

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.

Paek, Andrew L; Liu, Julia C; Loewer, Alexander; Forrester, William C; Lahav, Galit.

Cell ; 165(3): 631-42, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27062928

3.

Encoding and decoding cellular information through signaling dynamics.

Purvis, Jeremy E; Lahav, Galit.

Cell ; 152(5): 945-56, 2013 Feb 28.

Artigo em Inglês | MEDLINE | ID: mdl-23452846

4.

Cycling cancer persister cells arise from lineages with distinct programs.

Oren, Yaara; Tsabar, Michael; Cuoco, Michael S; Amir-Zilberstein, Liat; Cabanos, Heidie F; Hütter, Jan-Christian; Hu, Bomiao; Thakore, Pratiksha I; Tabaka, Marcin; Fulco, Charles P; Colgan, William; Cuevas, Brandon M; Hurvitz, Sara A; Slamon, Dennis J; Deik, Amy; Pierce, Kerry A; Clish, Clary; Hata, Aaron N; Zaganjor, Elma; Lahav, Galit; Politi, Katerina; Brugge, Joan S; Regev, Aviv.

Nature ; 596(7873): 576-582, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34381210

5.

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Reyes, José; Chen, Jia-Yun; Stewart-Ornstein, Jacob; Karhohs, Kyle W; Mock, Caroline S; Lahav, Galit.

Mol Cell ; 71(4): 581-591.e5, 2018 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-30057196

6.

MSModDetector: a tool for detecting mass shifts and post-translational modifications in individual ion mass spectrometry data.

Faizi, Marjan; Fellers, Ryan T; Lu, Dan; Drown, Bryon S; Jambhekar, Ashwini; Lahav, Galit; Kelleher, Neil L; Gunawardena, Jeremy.

Bioinformatics ; 40(6)2024 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-38796681

7.

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

Loewer, Alexander; Batchelor, Eric; Gaglia, Giorgio; Lahav, Galit.

Cell ; 142(1): 89-100, 2010 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-20598361

8.

Single-cell biology: what does the future hold?

Polychronidou, Maria; Hou, Jingyi; Babu, M Madan; Liberali, Prisca; Amit, Ido; Deplancke, Bart; Lahav, Galit; Itzkovitz, Shalev; Mann, Matthias; Saez-Rodriguez, Julio; Theis, Fabian; Eils, Roland.

Mol Syst Biol ; 19(7): e11799, 2023 Jul 11.

Artigo em Inglês | MEDLINE | ID: mdl-37318792

9.

Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations.

Jiménez, Alba; Lu, Dan; Kalocsay, Marian; Berberich, Matthew J; Balbi, Petra; Jambhekar, Ashwini; Lahav, Galit.

Mol Syst Biol ; 18(3): e10588, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35285572

10.

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Reyes, José; Chen, Jia-Yun; Stewart-Ornstein, Jacob; Karhohs, Kyle W; Mock, Caroline S; Lahav, Galit.

Mol Cell ; 73(6): 1306, 2019 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-30901565

11.

Fully unsupervised symmetry-based mitosis detection in time-lapse cell microscopy.

Gilad, Topaz; Reyes, Jose; Chen, Jia-Yun; Lahav, Galit; Riklin Raviv, Tammy.

Bioinformatics ; 35(15): 2644-2653, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-30590471

12.

The effect of dust storm particles on single human lung cancer cells.

Ardon-Dryer, Karin; Mock, Caroline; Reyes, Jose; Lahav, Galit.

Environ Res ; 181: 108891, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31740036

13.

Decoding the insulin signal.

Purvis, Jeremy E; Lahav, Galit.

Mol Cell ; 46(6): 715-6, 2012 Jun 29.

Artigo em Inglês | MEDLINE | ID: mdl-22749395

14.

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

Karanam, Ketki; Kafri, Ran; Loewer, Alexander; Lahav, Galit.

Mol Cell ; 47(2): 320-9, 2012 Jul 27.

Artigo em Inglês | MEDLINE | ID: mdl-22841003

15.

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.

Kafri, Ran; Levy, Jason; Ginzberg, Miriam B; Oh, Seungeun; Lahav, Galit; Kirschner, Marc W.

Nature ; 494(7438): 480-3, 2013 Feb 28.

Artigo em Inglês | MEDLINE | ID: mdl-23446419

16.

How to survive and thrive in the mother-mentor marathon.

Lahav, Galit.

Mol Cell ; 38(4): 477-80, 2010 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-20513421

17.

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

Batchelor, Eric; Mock, Caroline S; Bhan, Irun; Loewer, Alexander; Lahav, Galit.

Mol Cell ; 30(3): 277-89, 2008 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-18471974

18.

Activation and control of p53 tetramerization in individual living cells.

Gaglia, Giorgio; Guan, Yinghua; Shah, Jagesh V; Lahav, Galit.

Proc Natl Acad Sci U S A ; 110(38): 15497-501, 2013 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-24006363

19.

Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.

Gaglia, Giorgio; Lahav, Galit.

Mol Syst Biol ; 10: 753, 2014 Oct 24.

Artigo em Inglês | MEDLINE | ID: mdl-25344068

20.

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.

Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit.

BMC Biol ; 11: 114, 2013 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-24252182

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The multiple mechanisms that regulate p53 activity and cell fate.

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.

Encoding and decoding cellular information through signaling dynamics.

Cycling cancer persister cells arise from lineages with distinct programs.

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

MSModDetector: a tool for detecting mass shifts and post-translational modifications in individual ion mass spectrometry data.

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

Single-cell biology: what does the future hold?

Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations.

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Fully unsupervised symmetry-based mitosis detection in time-lapse cell microscopy.

The effect of dust storm particles on single human lung cancer cells.

Decoding the insulin signal.

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.

How to survive and thrive in the mother-mentor marathon.

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

Activation and control of p53 tetramerization in individual living cells.

Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.