Detalhe da pesquisa
1.
Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.
Bioorg Med Chem Lett
; 29(3): 367-372, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587451
2.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther
; 360(1): 1-13, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27754931
3.
Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.
Bioorg Med Chem Lett
; 25(22): 5163-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26463130
4.
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Bioorg Med Chem Lett
; 21(18): 5342-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21807507
5.
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
Bioorg Med Chem Lett
; 19(17): 5182-5, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19646870
6.
Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.
ACS Med Chem Lett
; 10(1): 50-55, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655946
7.
A small molecule-kinase interaction map for clinical kinase inhibitors.
Nat Biotechnol
; 23(3): 329-36, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15711537
8.
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
J Med Chem
; 61(17): 7917-7928, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30086626
9.
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).
J Med Chem
; 60(10): 4403-4423, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28471663
10.
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
Elife
; 52016 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27410477
11.
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
J Med Chem
; 58(12): 4888-904, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25879485
12.
Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
Elife
; 82019 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30614786
13.
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
J Med Chem
; 55(3): 1082-105, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22168626
14.
Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.
J Med Chem
; 52(23): 7808-16, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19754199