A novel method for monitoring the constancy of beam path accuracy in CyberKnife.

The aim of current work was to present a novel evaluation procedure implemented for checking the constancy of beam path accuracy of a CyberKnife system based on ArcCHECK. A tailor-made Styrofoam with four implanted fiducial markers was adopted to enable the fiducial tracking during beam deliveries. A simple two-field plan and an isocentric plan were created for determining the density override of ArcCHECK in MultiPlan and the constancy of beam path accuracy respectively. Correlation curves for all diodes involved in the study were obtained by analyzing the dose distributions calculated by MultiPlan after introducing position shifts in anteroposterior, superoinferior, and left-right directions. The ability of detecting systematic position error was also evaluated by changing the position of alignment center intentionally. The one standard deviation (SD) result for reproducibility test showed the RMS of 0.054 mm and the maximum of 0.263 mm, which was comparable to the machine self-test result. The mean of absolute value of position errors in the constancy test was measured to 0.091 mm with a SD of 0.035 mm, while the root-mean-square was 0.127 mm with a SD of 0.034 mm. All introduced systematic position errors range from 0.3 to 2 mm were detected successfully. Efficient method for evaluating the constancy of beam path accuracy of CyberKnife has been developed and proven to be sensitive enough for detecting a systematic drift of robotic manipulator. Once the workflow is streamlined, our proposed method will be an effective and easy quality assurance procedure for medical physicists.

Magnetic field induced dose effects in radiation therapy using MR-linacs.

MR-guided radiotherapy (MRgRT) is one of the most significant advances in radiotherapy in recent years. The hybrid systems were designed to visualize patient anatomical and physiological changes during the course of radiotherapy, enabling more precise treatment. However, before MR-linacs reach their full potential in delivering safe and accurate treatments to patients, the radiotherapy team must understand how a magnetic field alters the dosimetric properties of the radiation beam and its potential impact on treatment quality and clinical outcomes. This review aims to provide an in-depth description of the magnetic field induced dose effects for the two widely available systems, the 0.35 T and the 1.5 T MR-linacs. In MR-linac treatments, the primary photon beam passes through MR components that never exist in conventional linacs, which alter both in-field and out-of-field doses. More importantly, the interplay between the always-on magnetic field and the secondary electrons is not negligible. This interplay affects dose deposition in the patient, resulting in reduced in-field skin dose due to purged-out contaminant electrons, shortened build-up distance and a shifted crossline profile owing to asymmetric dose kernel. Especially two effects, namely, electron return effect (ERE) and electron stream effect (ESE), are not seen in conventional radiotherapy. This review also summarizes the clinical observations on the site-specific treatments influenced mostly by the magnetic field. In MR-linac treatment, the head and neck region is one of the most challenging sites as ERE occurs at low and high density tissue interfaces and around air cavities, generating hot and cold spots. In breast cancer treatment, consideration should be given to the increased in-field skin dose induced by ERE and the increased out-of-field dose caused by ESE for regions such as the ears, chin, and neck. In lung cancer treatments, tissue inhomogeneity combined with ERE will exacerbate target dose heterogeneity and increase or decrease interface dose. Lastly, treatment in the abdomen and pelvic region will be affected by the presence of gas pockets near the target. The review provides practical recommendations to mitigate these effects.

Clinical implementation of kVCT-guided tomotherapy with ClearRT.

A helical fan-beam kilovoltage computed tomography (kVCT) was recently introduced into Tomotherapy units. This study aims to share the initial experience of kVCT in clinical workflow, compare its performance with that of the existing megavoltage computed tomography (MVCT), and explore its potential in adaptive planning. We retrospectively enrolled 23 patients who underwent both MVCT and kVCT scans. The clinical performance data regarding image acquisition time, nominal dose length product (DLP), registration time and registration corrections were extracted and compared. Image quality was scored by six experienced radiation therapists and quantified based on phantom measurements. CT number stability and the implementation of adaptive radiotherapy were dosimetrically evaluated by performing the dose recalculation on kVCT. Compared to MVCT, kVCT significantly reduced DLP (except the highest kVp protocol), image acquisition and registration time. KVCT obtained higher scores than MVCT on all criteria except artifacts. Phantom measurements also revealed a better image performance characterization of kVCT except for image uniformity. The CT number variation could lead to a dose difference of 0.5% for D95% of target and Dmean of organ-at-risk. For the treatment planning with kVCT, a systematic dose difference (> 1%) in PTV dose metrics was observed at regions with large longitudinal density discontinuities compared to the reference plans. The new kVCT imaging provides enhanced soft-tissue visualization. The improved efficiency with kVCT-guided treatment will allow more patients to be treated each day. In most cases, the dose calculation accuracy of kVCT images is acceptable except for regions with severe artifacts.

Out-of-field dose and its constituent components for a 1.5 T MR-Linac.

This study aims to quantify the relative contributions of phantom scatter, collimator scatter and head leakage to the out-of-field doses (OFDs) of both static fields and clinical intensity-modulated radiation therapy (IMRT) treatments in a 1.5 T MR-Linac. The OFDs of static fields were measured at increasing distances from the field edge in an MR-conditional water phantom. Inline scans at depths of dmax (14 mm), 50 and 100 mm were performed for static fields of 5 × 5, 10 × 10 and 15 × 15 cm2under three different conditions: full scatter, with phantom scatter prevented, and head leakage only. Crossline scans at isocenter and offset positions were performed in full scatter condition. EBT3 radiochromic films were placed at 100 mm depth of solid water phantom to measure the OFD of clinical IMRT plans. All water tank data were normalized to Dmax of a 10 × 10 cm2field and the film results were presented as a fraction of the target mean dose.The OFD in the inline direction varied from 3.5% (15 × 15 cm2, 100 mm depth, 50 mm distance) to 0.014% (5 × 5 cm2, dmax, 400 mm distance). For all static fields, the collimator scatter was higher than the phantom scatter and head leakage at a distance of 100-400 mm. Head leakage remained the smallest among the three components, except at long distances (>375 mm) with small field size. Compared to the inline scans, the crossline scans at the isocenter showed higher doses at distances longer than 80 mm. All crossline profiles at longitudinal offset positions showed a cone shape with laterally shifted maxima. The OFD of IMRT deliveries varied with different target size. For prostate stereotactic body radiation therapy (SBRT) treatment, the OFD decreased from 2% to 0.03% at a distance of 50-500 mm. The OFDs have been measured for a 1.5 T MR-Linac. The presented dosimetric data are valuable for radiation safety assessments on patients treated with the MR-Linac, such as evaluating carcinogenic risk and radiation exposure to cardiac implantable electronic devices.

Effects on skin dose from unwanted air gaps under bolus in an MR-guided linear accelerator (MR-linac) system.

Bolus is commonly used in MV photon radiotherapy to increase superficial dose and improve dose uniformity for treating shallow lesions. However, irregular patient body contours can cause unwanted air gaps between a bolus and patient skin. The resulting dosimetric errors could be exacerbated in MR-Linac treatments, as secondary electrons generated by photons are affected by the magnetic field. This study aimed to quantify the dosimetric effect of unwanted gaps between bolus and skin surface in an MR-Linac. A parallel-plate ionization chamber and EBT3 films were utilized to evaluate the surface dose under bolus with various gantry angles, field sizes, and different air gaps. The results of surface dose measurements were then compared to Monaco 5.40 Treatment Planning System (TPS) calculations. The suitability of using a parallel-plate chamber in MR-Linac measurement was validated by benchmarking the percentage depth dose and output factors with the microDiamond detector and air-filled ionization chamber measurements in water. A non-symmetric response of the parallel-plate chamber to oblique beams in the magnetic field was characterized. Unwanted air gaps significantly reduced the skin dose. For a frontal beam, skin dose was halved when there was a 5 mm gap, a much larger difference than in a conventional linac. Skin dose manifested a non-symmetric pattern in terms of gantry angle and gap size. The TPS overestimated skin dose in general, but shared the same trend with measurement when there was no air gap, or the gap size was larger than 5 mm. However, the calculated and measured results had a large discrepancy when the bolus-skin gap was below 5 mm. When treating superficial lesions, unwanted air gaps under the bolus will compromise the dosimetric goals. Our results highlight the importance of avoiding air gaps between bolus and skin when treating superficial lesions using an MR-Linac system.

Development of a novel methodology for QA of respiratory-gated and VMAT beam delivery using Octavius 4D phantom.

The objective of this study was to develop and evaluate a series of quality assurance (QA) techniques based on Octavius 4D phantom for testing of respiratory-gated treatment delivery, integrity of dose rate vs gantry speed in volumetric-modulated arc therapy (VMAT) commissioning, and multileaf collimator (MLC) positioning accuracy of a linear accelerator. An Octavius 4D phantom capable of rotating with the gantry and recording the detector signal with a sampling rate of 10 Hz was isocentrally set up and an inclinometer was also installed to measure the gantry angle simultaneously. A simple arc test was created and delivered with gating function activated to measure the timing accuracy of the gating window. A tailor-made dose rate vs gantry speed plan was also designed to test the accuracy of measured dose rate, gantry speed, and actual control points. All experiments were conducted while machine log files were collected for comparison. The variations of beam flatness, symmetry, and field size were analyzed as a function of gantry angle to evaluate the influence from the modulation of dose rate and gantry speed. MLC position accuracy was evaluated based on specific garden fence plans. The time of gating window was measured to be less than 10-millisecond deviation from the log data. Gantry backlash was observed and quantified to be 1.72° with an extra stabilization time of 1.16 seconds for a gating arc with gantry speed of 6°/s. In the dose rate vs gantry speed test, the mean deviation between measured gantry angle and log data was less than 0.2° after a time delay of 0.25 second was corrected. The measured dose rate agreed with the log data very well with a mean deviation of 0.05%, and even the transit of modulation was tracked successfully. There was a statistically significant difference on the variation of beam parameters between a VMAT plan and a simple arc plan. The induced MLC position errors were detected with an accuracy of 0.05 mm. The leaf position reproducibility was found to be better than 0.02 mm, whereas the routine MLC position accuracy was better than 0.1 mm. A time-resolved method using Octavius 4D phantom has been developed and proven to be convenient for respiratory gating QA, dose rate vs gantry speed test, and MLC QA. Gating time, dose rate, and gantry speed-induced leave position error could be directly measured with high accuracy after comparison with the machine log data. This study also highlights the capability of the phantom in quantifying the variation of flatness, symmetry, and field size during gantry rotation.

Performance evaluation of the CyberKnife system in real-time target tracking during beam delivery using a moving phantom coupled with two-dimensional detector array.

The aim of the current study was to evaluate the tracking error of the Synchrony Respiratory Tracking system by conducting beam-by-beam analyses to determine the variation in the tracking beams measured during target motion. A moving phantom of in-house design coupled with a two-dimensional (2D) detector array was used to simulate respiratory motion in the superoinferior (SI) and anteroposterior (AP) direction. A styrofoam block with four implanted fiducial markers was placed on top of the detector to enable the fiducial-based respiratory tracking. Measurements were performed with the phantom under either stationary mode or sinusoidal motion of 6-s cycle and 15/20-mm amplitude at SI and AP direction. The measurement data were saved as movie files that were used to calculate the center shift of the beam with 100-ms sampling time. The tracking accuracy of the system was defined as the targeting error, which could be tracked with probability of > 95% (Ep95). The mean ± standard deviation of Ep95 was 0.28 ± 0.08 mm under stationary condition; 0.66 ± 0.23 mm (range: 0.28-1.22 mm) under sinusoidal respiratory motion. The maximum drift of the beam center for all beam paths was 2.7 mm. The tracking accuracy of CyberKnife Synchrony system was successfully evaluated using a moving phantom and 2D detector array; the maximum tracking error was < 1.5 mm for sinusoidal motion of amplitude ≤ 20 mm.

Accuracy in contouring of small and low contrast lesions: comparison between diagnostic quality computed tomography scanner and computed tomography simulation scanner-A phantom study.

To evaluate the accuracy in detection of small and low-contrast regions using a high-definition diagnostic computed tomography (CT) scanner compared with a radiotherapy CT simulation scanner. A custom-made phantom with cylindrical holes of diameters ranging from 2-9 mm was filled with 9 different concentrations of contrast solution. The phantom was scanned using a 16-slice multidetector CT simulation scanner (LightSpeed RT16, General Electric Healthcare, Milwaukee, WI) and a 64-slice high-definition diagnostic CT scanner (Discovery CT750 HD, General Electric Healthcare). The low-contrast regions of interest (ROIs) were delineated automatically upon their full width at half maximum of the CT number profile in Hounsfield units on a treatment planning workstation. Two conformal indexes, CI(in), and CI(out), were calculated to represent the percentage errors of underestimation and overestimation in the automated contours compared with their actual sizes. Summarizing the conformal indexes of different sizes and contrast concentration, the means of CI(in) and CI(out) for the CT simulation scanner were 33.7% and 60.9%, respectively, and 10.5% and 41.5% were found for the diagnostic CT scanner. The mean differences between the 2 scanners' CI(in) and CI(out) were shown to be significant with p < 0.001. A descending trend of the index values was observed as the ROI size increases for both scanners, which indicates an improved accuracy when the ROI size increases, whereas no observable trend was found in the contouring accuracy with respect to the contrast levels in this study. Images acquired by the diagnostic CT scanner allow higher accuracy on size estimation compared with the CT simulation scanner in this study. We recommend using a diagnostic CT scanner to scan patients with small lesions (<1 cm in diameter) for radiotherapy treatment planning, especially for those pending for stereotactic radiosurgery in which accurate delineation of small-sized, low-contrast regions is important for dose calculation.

The dosimetric effect of zipper artifacts on tomotherapy adaptive dose calculation--a phantom study.

Tomotherapy adaptive dose calculation offers the ability to verify and adjust the therapeutic plan during the treatment. Using tomotherapy adaptive dose calculation, the planned fluence pattern can be used to recalculate the dose distribution on pretreatment megavoltage computed tomography (MVCT) images. Zipper artifacts, which appear as increased density in the central region of MVCT images, may affect the accuracy of adaptive dose recalculation. The purpose of this study was to evaluate the dosimetric effects of zipper artifacts on tomotherapy adaptive dose calculation. MVCT images of a cylindrical water phantom of 22-cm diameter were acquired on a tomotherapy system. The zipper artifacts were enclosed by a cylindrical planning target volume (PTV) contoured on these images. For comparison, artifact-free images were created by replacing the computed tomography (CT) numbers of zipper artifacts with the mean CT number of water. Treatment plans were generated by giving a uniform dose of 2 Gy to the PTV based on these modified images; it was then applied to the images that have the zipper artifacts. The impacts of different pitch ratios on the artifacts were assessed. The dose distribution differences between the 2 sets of images were compared. The absorbed dose that covered 95% volume of PTV and maximum dose, minimum dose, and mean dose of the PTV were also calculated and compared. The water phantom was scanned on the tomotherapy system twice per week for 12 consecutive weeks. The mean CT number of zipper artifacts (101 HU) was three times higher than that of water (34 HU). The CT number value and location of zipper artifacts were not affected by the pitch ratio. Gamma analysis was performed between the original and recalculated dose distributions. The discrepancies between the isodose distributions calculated by two sets of images were within 1%/1-mm tolerance. The dosimetric impact from zipper artifacts was found insignificant such that the recalculated dose was underestimated by less than 0.5%.