Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

Subramanian, Aravind; Narayan, Rajiv; Corsello, Steven M; Peck, David D; Natoli, Ted E; Lu, Xiaodong; Gould, Joshua; Davis, John F; Tubelli, Andrew A; Asiedu, Jacob K; Lahr, David L; Hirschman, Jodi E; Liu, Zihan; Donahue, Melanie; Julian, Bina; Khan, Mariya; Wadden, David; Smith, Ian C; Lam, Daniel; Liberzon, Arthur; Toder, Courtney; Bagul, Mukta; Orzechowski, Marek; Enache, Oana M; Piccioni, Federica; Johnson, Sarah A; Lyons, Nicholas J; Berger, Alice H; Shamji, Alykhan F; Brooks, Angela N; Vrcic, Anita; Flynn, Corey; Rosains, Jacqueline; Takeda, David Y; Hu, Roger; Davison, Desiree; Lamb, Justin; Ardlie, Kristin; Hogstrom, Larson; Greenside, Peyton; Gray, Nathanael S; Clemons, Paul A; Silver, Serena; Wu, Xiaoyun; Zhao, Wen-Ning; Read-Button, Willis; Wu, Xiaohua; Haggarty, Stephen J; Ronco, Lucienne V; Boehm, Jesse S.

Cell ; 171(6): 1437-1452.e17, 2017 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-29195078

2.

NHC-Catalyzed Aza-Benzoin Condensation of N,N'-Dipyridin-2-yl Aminals with Aldehydes.

Lamb, Justin S; Takashima, Ryo; Suzuki, Yumiko.

J Org Chem ; 86(15): 10224-10234, 2021 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-34291942

3.

Light-controlled modulation of gene expression by chemical optoepigenetic probes.

Reis, Surya A; Ghosh, Balaram; Hendricks, J Adam; Szantai-Kis, D Miklos; Törk, Lisa; Ross, Kenneth N; Lamb, Justin; Read-Button, Willis; Zheng, Baixue; Wang, Hongtao; Salthouse, Christopher; Haggarty, Stephen J; Mazitschek, Ralph.

Nat Chem Biol ; 12(5): 317-23, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-26974814

4.

Correction to "NHC-Catalyzed Aza-Benzoin Condensation of N,N'-Dipyridin-2-yl Aminals with Aldehydes".

Lamb, Justin S; Takashima, Ryo; Suzuki, Yumiko.

J Org Chem ; 86(18): 13176, 2021 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-34474561

5.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer, Michael; Ebert, Benjamin L; Neil, Christopher; Brenner, Keith; Papaioannou, Ioannis; Melas, Antonia; Tolliday, Nicola; Lamb, Justin; Pantopoulos, Kostas; Golub, Todd; Iliopoulos, Othon.

Mol Cell ; 32(6): 838-48, 2008 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-19111663

6.

The Connectivity Map: a new tool for biomedical research.

Lamb, Justin.

Nat Rev Cancer ; 7(1): 54-60, 2007 01.

Artigo em Inglês | MEDLINE | ID: mdl-17186018

7.

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.

Wei, Guo; Twomey, David; Lamb, Justin; Schlis, Krysta; Agarwal, Jyoti; Stam, Ronald W; Opferman, Joseph T; Sallan, Stephen E; den Boer, Monique L; Pieters, Rob; Golub, Todd R; Armstrong, Scott A.

Cancer Cell ; 10(4): 331-42, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17010674

8.

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

Hieronymus, Haley; Lamb, Justin; Ross, Kenneth N; Peng, Xiao P; Clement, Cristina; Rodina, Anna; Nieto, Maria; Du, Jinyan; Stegmaier, Kimberly; Raj, Srilakshmi M; Maloney, Katherine N; Clardy, Jon; Hahn, William C; Chiosis, Gabriela; Golub, Todd R.

Cancer Cell ; 10(4): 321-30, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17010675

9.

Synthesis and Biological Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents.

Tanaka, Hiroaki; Miyagi, Seiya; Yoshida, Yusuke; Lamb, Justin Steven; Chick, Christian Nanga; Luhata, Lokadi Pierre; Shibata, Mizuho; Tanaka, Eri; Suzuki, Yumiko; Usuki, Toyonobu.

ChemistrySelect ; 7(30): e202202097, 2022 Aug 12.

Artigo em Inglês | MEDLINE | ID: mdl-36245851

10.

MicroRNA expression profiles classify human cancers.

Lu, Jun; Getz, Gad; Miska, Eric A; Alvarez-Saavedra, Ezequiel; Lamb, Justin; Peck, David; Sweet-Cordero, Alejandro; Ebert, Benjamin L; Mak, Raymond H; Ferrando, Adolfo A; Downing, James R; Jacks, Tyler; Horvitz, H Robert; Golub, Todd R.

Nature ; 435(7043): 834-8, 2005 Jun 09.

Artigo em Inglês | MEDLINE | ID: mdl-15944708

11.

Positive and negative regulation of deltaN-p63 promoter activity by p53 and deltaN-p63-alpha contributes to differential regulation of p53 target genes.

Harmes, David Christopher; Bresnick, Edward; Lubin, Emma A; Watson, Julie K; Heim, Kelly E; Curtin, Joshua C; Suskind, Anne M; Lamb, Justin; DiRenzo, James.

Oncogene ; 22(48): 7607-16, 2003 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-14576823

12.

The activities of cyclin D1 that drive tumorigenesis.

Ewen, Mark E; Lamb, Justin.

Trends Mol Med ; 10(4): 158-62, 2004 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15059606

13.

Cyclin D1 and molecular chaperones: implications for tumorigenesis.

Lamb, Justin; Ewen, Mark E.

Cell Cycle ; 2(6): 525-7, 2003.

Artigo em Inglês | MEDLINE | ID: mdl-14504466

14.

Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields.

Harris, Paul A; Lamb, Justin; Heaton, Brian; Wheatley, Denys N.

Cancer Cell Int ; 2(1): 3, 2002 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-12069691

15.

Pathways of Toxicity.

Kleensang, Andre; Maertens, Alexandra; Rosenberg, Michael; Fitzpatrick, Suzanne; Lamb, Justin; Auerbach, Scott; Brennan, Richard; Crofton, Kevin M; Gordon, Ben; Fornace, Albert J; Gaido, Kevin; Gerhold, David; Haw, Robin; Henney, Adriano; Ma'ayan, Avi; McBride, Mary; Monti, Stefano; Ochs, Michael F; Pandey, Akhilesh; Sharan, Roded; Stierum, Rob; Tugendreich, Stuart; Willett, Catherine; Wittwehr, Clemens; Xia, Jianguo; Patton, Geoffrey W; Arvidson, Kirk; Bouhifd, Mounir; Hogberg, Helena T; Luechtefeld, Thomas; Smirnova, Lena; Zhao, Liang; Adeleye, Yeyejide; Kanehisa, Minoru; Carmichael, Paul; Andersen, Melvin E; Hartung, Thomas.

ALTEX ; 31(1): 53-61, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24127042

16.

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.

Zimmer, Michael; Lamb, Justin; Ebert, Benjamin L; Lynch, Mary; Neil, Christopher; Schmidt, Emmett; Golub, Todd R; Iliopoulos, Othon.

Cancer Res ; 70(8): 3071-9, 2010 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-20354189

17.

A method for high-throughput gene expression signature analysis.

Peck, David; Crawford, Emily D; Ross, Kenneth N; Stegmaier, Kimberly; Golub, Todd R; Lamb, Justin.

Genome Biol ; 7(7): R61, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16859521

18.

Why do beliefs about intelligence influence learning success? A social cognitive neuroscience model.

Mangels, Jennifer A; Butterfield, Brady; Lamb, Justin; Good, Catherine; Dweck, Carol S.

Soc Cogn Affect Neurosci ; 1(2): 75-86, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-17392928

19.

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements.

Dostie, Josée; Richmond, Todd A; Arnaout, Ramy A; Selzer, Rebecca R; Lee, William L; Honan, Tracey A; Rubio, Eric D; Krumm, Anton; Lamb, Justin; Nusbaum, Chad; Green, Roland D; Dekker, Job.

Genome Res ; 16(10): 1299-309, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16954542

20.

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Lamb, Justin; Crawford, Emily D; Peck, David; Modell, Joshua W; Blat, Irene C; Wrobel, Matthew J; Lerner, Jim; Brunet, Jean-Philippe; Subramanian, Aravind; Ross, Kenneth N; Reich, Michael; Hieronymus, Haley; Wei, Guo; Armstrong, Scott A; Haggarty, Stephen J; Clemons, Paul A; Wei, Ru; Carr, Steven A; Lander, Eric S; Golub, Todd R.

Science ; 313(5795): 1929-35, 2006 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-17008526

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