Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The Human Transcription Factors.

Lambert, Samuel A; Jolma, Arttu; Campitelli, Laura F; Das, Pratyush K; Yin, Yimeng; Albu, Mihai; Chen, Xiaoting; Taipale, Jussi; Hughes, Timothy R; Weirauch, Matthew T.

Cell ; 172(4): 650-665, 2018 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-29425488

2.

Determination and inference of eukaryotic transcription factor sequence specificity.

Weirauch, Matthew T; Yang, Ally; Albu, Mihai; Cote, Atina G; Montenegro-Montero, Alejandro; Drewe, Philipp; Najafabadi, Hamed S; Lambert, Samuel A; Mann, Ishminder; Cook, Kate; Zheng, Hong; Goity, Alejandra; van Bakel, Harm; Lozano, Jean-Claude; Galli, Mary; Lewsey, Mathew G; Huang, Eryong; Mukherjee, Tuhin; Chen, Xiaoting; Reece-Hoyes, John S; Govindarajan, Sridhar; Shaulsky, Gad; Walhout, Albertha J M; Bouget, François-Yves; Ratsch, Gunnar; Larrondo, Luis F; Ecker, Joseph R; Hughes, Timothy R.

Cell ; 158(6): 1431-1443, 2014 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-25215497

3.

An atlas of genetic scores to predict multi-omic traits.

Xu, Yu; Ritchie, Scott C; Liang, Yujian; Timmers, Paul R H J; Pietzner, Maik; Lannelongue, Loïc; Lambert, Samuel A; Tahir, Usman A; May-Wilson, Sebastian; Foguet, Carles; Johansson, Åsa; Surendran, Praveen; Nath, Artika P; Persyn, Elodie; Peters, James E; Oliver-Williams, Clare; Deng, Shuliang; Prins, Bram; Luan, Jian'an; Bomba, Lorenzo; Soranzo, Nicole; Di Angelantonio, Emanuele; Pirastu, Nicola; Tai, E Shyong; van Dam, Rob M; Parkinson, Helen; Davenport, Emma E; Paul, Dirk S; Yau, Christopher; Gerszten, Robert E; Mälarstig, Anders; Danesh, John; Sim, Xueling; Langenberg, Claudia; Wilson, James F; Butterworth, Adam S; Inouye, Michael.

Nature ; 616(7955): 123-131, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36991119

4.

The Human Transcription Factors.

Lambert, Samuel A; Jolma, Arttu; Campitelli, Laura F; Das, Pratyush K; Yin, Yimeng; Albu, Mihai; Chen, Xiaoting; Taipale, Jussi; Hughes, Timothy R; Weirauch, Matthew T.

Cell ; 175(2): 598-599, 2018 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-30290144

5.

Improving reporting standards for polygenic scores in risk prediction studies.

Wand, Hannah; Lambert, Samuel A; Tamburro, Cecelia; Iacocca, Michael A; O'Sullivan, Jack W; Sillari, Catherine; Kullo, Iftikhar J; Rowley, Robb; Dron, Jacqueline S; Brockman, Deanna; Venner, Eric; McCarthy, Mark I; Antoniou, Antonis C; Easton, Douglas F; Hegele, Robert A; Khera, Amit V; Chatterjee, Nilanjan; Kooperberg, Charles; Edwards, Karen; Vlessis, Katherine; Kinnear, Kim; Danesh, John N; Parkinson, Helen; Ramos, Erin M; Roberts, Megan C; Ormond, Kelly E; Khoury, Muin J; Janssens, A Cecile J W; Goddard, Katrina A B; Kraft, Peter; MacArthur, Jaqueline A L; Inouye, Michael; Wojcik, Genevieve L.

Nature ; 591(7849): 211-219, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33692554

6.

The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource.

Sollis, Elliot; Mosaku, Abayomi; Abid, Ala; Buniello, Annalisa; Cerezo, Maria; Gil, Laurent; Groza, Tudor; Günes, Osman; Hall, Peggy; Hayhurst, James; Ibrahim, Arwa; Ji, Yue; John, Sajo; Lewis, Elizabeth; MacArthur, Jacqueline A L; McMahon, Aoife; Osumi-Sutherland, David; Panoutsopoulou, Kalliope; Pendlington, Zoë; Ramachandran, Santhi; Stefancsik, Ray; Stewart, Jonathan; Whetzel, Patricia; Wilson, Robert; Hindorff, Lucia; Cunningham, Fiona; Lambert, Samuel A; Inouye, Michael; Parkinson, Helen; Harris, Laura W.

Nucleic Acids Res ; 51(D1): D977-D985, 2023 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-36350656

7.

Towards clinical utility of polygenic risk scores.

Lambert, Samuel A; Abraham, Gad; Inouye, Michael.

Hum Mol Genet ; 28(R2): R133-R142, 2019 11 21.

Artigo em Inglês | MEDLINE | ID: mdl-31363735

8.

Motif comparison based on similarity of binding affinity profiles.

Lambert, Samuel A; Albu, Mihai; Hughes, Timothy R; Najafabadi, Hamed S.

Bioinformatics ; 32(22): 3504-3506, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27466627

9.

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools.

Xiang, Ruidong; Kelemen, Martin; Xu, Yu; Harris, Laura W; Parkinson, Helen; Inouye, Michael; Lambert, Samuel A.

Genome Med ; 16(1): 33, 2024 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-38373998

10.

Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.

Xiang, Ruidong; Liu, Yang; Ben-Eghan, Chief; Ritchie, Scott; Lambert, Samuel A; Xu, Yu; Takeuchi, Fumihiko; Inouye, Michael.

medRxiv ; 2024 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-38699308

11.

What makes a good life: using theatrical performance to enhance communication about polygenic risk scores research in patient and public involvement.

Mason, Amy M; Obi, Ifunanya; Ayodele, Olamide; Lambert, Samuel A; Fahle, Sarah.

J Community Genet ; 14(5): 453-458, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-36763324

12.

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.

Ritchie, Scott C; Surendran, Praveen; Karthikeyan, Savita; Lambert, Samuel A; Bolton, Thomas; Pennells, Lisa; Danesh, John; Di Angelantonio, Emanuele; Butterworth, Adam S; Inouye, Michael.

Sci Data ; 10(1): 64, 2023 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-36720882

13.

Genetically personalised organ-specific metabolic models in health and disease.

Foguet, Carles; Xu, Yu; Ritchie, Scott C; Lambert, Samuel A; Persyn, Elodie; Nath, Artika P; Davenport, Emma E; Roberts, David J; Paul, Dirk S; Di Angelantonio, Emanuele; Danesh, John; Butterworth, Adam S; Yau, Christopher; Inouye, Michael.

Nat Commun ; 13(1): 7356, 2022 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-36446790

14.

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.

Huang, Qin Qin; Sallah, Neneh; Dunca, Diana; Trivedi, Bhavi; Hunt, Karen A; Hodgson, Sam; Lambert, Samuel A; Arciero, Elena; Wright, John; Griffiths, Chris; Trembath, Richard C; Hemingway, Harry; Inouye, Michael; Finer, Sarah; van Heel, David A; Lumbers, R Thomas; Martin, Hilary C; Kuchenbaecker, Karoline.

Nat Commun ; 13(1): 4664, 2022 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-35945198

15.

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.

Ritchie, Scott C; Lambert, Samuel A; Arnold, Matthew; Teo, Shu Mei; Lim, Sol; Scepanovic, Petar; Marten, Jonathan; Zahid, Sohail; Chaffin, Mark; Liu, Yingying; Abraham, Gad; Ouwehand, Willem H; Roberts, David J; Watkins, Nicholas A; Drew, Brian G; Calkin, Anna C; Di Angelantonio, Emanuele; Soranzo, Nicole; Burgess, Stephen; Chapman, Michael; Kathiresan, Sekar; Khera, Amit V; Danesh, John; Butterworth, Adam S; Inouye, Michael.

Nat Metab ; 3(11): 1476-1483, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34750571

16.

Similarity regression predicts evolution of transcription factor sequence specificity.

Lambert, Samuel A; Yang, Ally W H; Sasse, Alexander; Cowley, Gwendolyn; Albu, Mihai; Caddick, Mark X; Morris, Quaid D; Weirauch, Matthew T; Hughes, Timothy R.

Nat Genet ; 51(6): 981-989, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31133749

17.

Comparison of ChIP-Seq Data and a Reference Motif Set for Human KRAB C2H2 Zinc Finger Proteins.

Barazandeh, Marjan; Lambert, Samuel A; Albu, Mihai; Hughes, Timothy R.

G3 (Bethesda) ; 8(1): 219-229, 2018 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-29146583

18.

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation.

Lambert, Samuel A; Gil, Laurent; Jupp, Simon; Ritchie, Scott C; Xu, Yu; Buniello, Annalisa; McMahon, Aoife; Abraham, Gad; Chapman, Michael; Parkinson, Helen; Danesh, John; MacArthur, Jacqueline A L; Inouye, Michael.

Nat Genet ; 53(4): 420-425, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33692568

19.

Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities.

Narasimhan, Kamesh; Lambert, Samuel A; Yang, Ally W H; Riddell, Jeremy; Mnaimneh, Sanie; Zheng, Hong; Albu, Mihai; Najafabadi, Hamed S; Reece-Hoyes, John S; Fuxman Bass, Juan I; Walhout, Albertha J M; Weirauch, Matthew T; Hughes, Timothy R.

Elife ; 42015 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-25905672

20.

Transcription factors read epigenetics.

Hughes, Timothy R; Lambert, Samuel A.

Science ; 356(6337): 489-490, 2017 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-28473550

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The Human Transcription Factors.

Determination and inference of eukaryotic transcription factor sequence specificity.

An atlas of genetic scores to predict multi-omic traits.

The Human Transcription Factors.

Improving reporting standards for polygenic scores in risk prediction studies.

The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource.

Towards clinical utility of polygenic risk scores.

Motif comparison based on similarity of binding affinity profiles.

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools.

Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.

What makes a good life: using theatrical performance to enhance communication about polygenic risk scores research in patient and public involvement.

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.

Genetically personalised organ-specific metabolic models in health and disease.

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.

Similarity regression predicts evolution of transcription factor sequence specificity.

Comparison of ChIP-Seq Data and a Reference Motif Set for Human KRAB C2H2 Zinc Finger Proteins.

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation.

Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities.

Transcription factors read epigenetics.