Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Yan, Chuan; Brunson, Dalton C; Tang, Qin; Do, Daniel; Iftimia, Nicolae A; Moore, John C; Hayes, Madeline N; Welker, Alessandra M; Garcia, Elaine G; Dubash, Taronish D; Hong, Xin; Drapkin, Benjamin J; Myers, David T; Phat, Sarah; Volorio, Angela; Marvin, Dieuwke L; Ligorio, Matteo; Dershowitz, Lyle; McCarthy, Karin M; Karabacak, Murat N; Fletcher, Jonathan A; Sgroi, Dennis C; Iafrate, John A; Maheswaran, Shyamala; Dyson, Nick J; Haber, Daniel A; Rawls, John F; Langenau, David M.

Cell ; 177(7): 1903-1914.e14, 2019 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-31031007

2.

Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

Langenau, David M; Keefe, Matthew D; Storer, Narie Y; Guyon, Jeffrey R; Kutok, Jeffery L; Le, Xiuning; Goessling, Wolfram; Neuberg, Donna S; Kunkel, Louis M; Zon, Leonard I.

Genes Dev ; 38(5-6): 289, 2024 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-38631822

3.

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.

Laukkanen, Saara; Veloso, Alexandra; Yan, Chuan; Oksa, Laura; Alpert, Eric J; Do, Daniel; Hyvärinen, Noora; McCarthy, Karin; Adhikari, Abhinav; Yang, Qiqi; Iyer, Sowmya; Garcia, Sara P; Pello, Annukka; Ruokoranta, Tanja; Moisio, Sanni; Adhikari, Sadiksha; Yoder, Jeffrey A; Gallagher, Kayleigh; Whelton, Lauren; Allen, James R; Jin, Alex H; Loontiens, Siebe; Heinäniemi, Merja; Kelliher, Michelle; Heckman, Caroline A; Lohi, Olli; Langenau, David M.

Blood ; 140(17): 1891-1906, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-35544598

4.

Zebrafish as a high throughput model for organ preservation and transplantation research.

Da Silveira Cavalcante, Luciana; Lopera Higuita, Manuela; González-Rosa, Juan Manuel; Marques, Beatriz; To, Samantha; Pendexter, Casie A; Cronin, Stephanie E J; Gopinathan, Kaustav; de Vries, Reinier J; Ellett, Felix; Uygun, Korkut; Langenau, David M; Toner, Mehmet; Tessier, Shannon N.

FASEB J ; 37(10): e23187, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37718489

5.

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.

Cardoso, Bruno A; Duque, Mafalda; Gírio, Ana; Fragoso, Rita; Oliveira, Mariana L; Allen, James R; Martins, Leila R; Correia, Nádia C; Silveira, André Bortolini; Veloso, Alexandra; Kimura, Shunsuke; Demoen, Lisa; Matthijssens, Filip; Jeha, Sima; Cheng, Cheng; Pui, Ching-Hon; Grosso, Ana R; Neto, João L; De Almeida, Sérgio F; Van Vlieberghe, Pieter; Mullighan, Charles G; Yunes, J Andres; Langenau, David M; Pflumio, Françoise; Barata, João T.

Haematologica ; 2023 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-38058200

6.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham, Jinu; Nuñez-Álvarez, Yaiza; Hettmer, Simone; Carrió, Elvira; Chen, Hung-I Harry; Nishijo, Koichi; Huang, Elaine T; Prajapati, Suresh I; Walker, Robert L; Davis, Sean; Rebeles, Jennifer; Wiebush, Hunter; McCleish, Amanda T; Hampton, Sheila T; Bjornson, Christopher R R; Brack, Andrew S; Wagers, Amy J; Rando, Thomas A; Capecchi, Mario R; Marini, Frank C; Ehler, Benjamin R; Zarzabal, Lee Ann; Goros, Martin W; Michalek, Joel E; Meltzer, Paul S; Langenau, David M; LeGallo, Robin D; Mansoor, Atiya; Chen, Yidong; Suelves, Mònica; Rubin, Brian P; Keller, Charles.

Genes Dev ; 28(14): 1578-91, 2014 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-25030697

7.

Insights into pediatric rhabdomyosarcoma research: Challenges and goals.

Yohe, Marielle E; Heske, Christine M; Stewart, Elizabeth; Adamson, Peter C; Ahmed, Nabil; Antonescu, Cristina R; Chen, Eleanor; Collins, Natalie; Ehrlich, Alan; Galindo, Rene L; Gryder, Berkley E; Hahn, Heidi; Hammond, Sharon; Hatley, Mark E; Hawkins, Douglas S; Hayes, Madeline N; Hayes-Jordan, Andrea; Helman, Lee J; Hettmer, Simone; Ignatius, Myron S; Keller, Charles; Khan, Javed; Kirsch, David G; Linardic, Corinne M; Lupo, Philip J; Rota, Rossella; Shern, Jack F; Shipley, Janet; Sindiri, Sivasish; Tapscott, Stephen J; Vakoc, Christopher R; Wexler, Leonard H; Langenau, David M.

Pediatr Blood Cancer ; 66(10): e27869, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31222885

8.

Clusters of circulating tumor cells traverse capillary-sized vessels.

Au, Sam H; Storey, Brian D; Moore, John C; Tang, Qin; Chen, Yeng-Long; Javaid, Sarah; Sarioglu, A Fatih; Sullivan, Ryan; Madden, Marissa W; O'Keefe, Ryan; Haber, Daniel A; Maheswaran, Shyamala; Langenau, David M; Stott, Shannon L; Toner, Mehmet.

Proc Natl Acad Sci U S A ; 113(18): 4947-52, 2016 May 03.

Artigo em Inglês | MEDLINE | ID: mdl-27091969

9.

Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.

Berberoglu, Michael A; Gallagher, Thomas L; Morrow, Zachary T; Talbot, Jared C; Hromowyk, Kimberly J; Tenente, Inês M; Langenau, David M; Amacher, Sharon L.

Dev Biol ; 424(2): 162-180, 2017 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-28279710

10.

Optimized cell transplantation using adult rag2 mutant zebrafish.

Tang, Qin; Abdelfattah, Nouran S; Blackburn, Jessica S; Moore, John C; Martinez, Sarah A; Moore, Finola E; Lobbardi, Riadh; Tenente, Inês M; Ignatius, Myron S; Berman, Jason N; Liwski, Robert S; Houvras, Yariv; Langenau, David M.

Nat Methods ; 11(8): 821-4, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25042784

11.

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/ß-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.

Chen, Eleanor Y; DeRan, Michael T; Ignatius, Myron S; Grandinetti, Kathryn Brooke; Clagg, Ryan; McCarthy, Karin M; Lobbardi, Riadh M; Brockmann, Jillian; Keller, Charles; Wu, Xu; Langenau, David M.

Proc Natl Acad Sci U S A ; 111(14): 5349-54, 2014 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-24706870

12.

Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.

Storer, Narie Y; White, Richard M; Uong, Audrey; Price, Emily; Nielsen, G Petur; Langenau, David M; Zon, Leonard I.

Development ; 140(14): 3040-50, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23821038

13.

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

Le, Xiuning; Pugach, Emily K; Hettmer, Simone; Storer, Narie Y; Liu, Jianing; Wills, Airon A; DiBiase, Antony; Chen, Eleanor Y; Ignatius, Myron S; Poss, Kenneth D; Wagers, Amy J; Langenau, David M; Zon, Leonard I.

Development ; 140(11): 2354-64, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23615277

14.

Pten regulates zebrafish hematopoiesis.

Langenau, David M.

Blood ; 123(2): 149-50, 2014 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-24408201

15.

Allograft Cancer Cell Transplantation in Zebrafish.

Moore, John C; Langenau, David M.

Adv Exp Med Biol ; 916: 265-87, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27165358

16.

In Vivo Imaging of Cancer in Zebrafish.

Ignatius, Myron S; Hayes, Madeline; Langenau, David M.

Adv Exp Med Biol ; 916: 219-37, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27165356

17.

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.

Chen, Eleanor Y; Dobrinski, Kimberly P; Brown, Kim H; Clagg, Ryan; Edelman, Elena; Ignatius, Myron S; Chen, Jin Yun Helen; Brockmann, Jillian; Nielsen, G Petur; Ramaswamy, Sridhar; Keller, Charles; Lee, Charles; Langenau, David M.

PLoS Genet ; 9(8): e1003727, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24009521

18.

The zebrafish: a new model of T-cell and thymic development.

Langenau, David M; Zon, Leonard I.

Nat Rev Immunol ; 5(4): 307-17, 2005 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15803150

19.

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.

Gutierrez, Alejandro; Feng, Hui; Stevenson, Kristen; Neuberg, Donna S; Calzada, Oscar; Zhou, Yi; Langenau, David M; Look, A Thomas.

Br J Haematol ; 166(1): 84-90, 2014 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-24690081

20.

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

Sander, Jeffry D; Dahlborg, Elizabeth J; Goodwin, Mathew J; Cade, Lindsay; Zhang, Feng; Cifuentes, Daniel; Curtin, Shaun J; Blackburn, Jessica S; Thibodeau-Beganny, Stacey; Qi, Yiping; Pierick, Christopher J; Hoffman, Ellen; Maeder, Morgan L; Khayter, Cyd; Reyon, Deepak; Dobbs, Drena; Langenau, David M; Stupar, Robert M; Giraldez, Antonio J; Voytas, Daniel F; Peterson, Randall T; Yeh, Jing-Ruey J; Joung, J Keith.

Nat Methods ; 8(1): 67-9, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21151135

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