Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A Phase 1B Trial in GBA1-Associated Parkinson's Disease of BIA-28-6156, a Glucocerebrosidase Activator.

den Heijer, Jonas M; Kruithof, Annelieke C; Moerland, Matthijs; Walker, Mike; Dudgeon, Lindsay; Justman, Craig; Solomini, Imelda; Splitalny, Leslie; Leymarie, Nancy; Khatri, Kshitij; Cullen, Valerie C; Hilt, Dana C; Groeneveld, Geert Jan; Lansbury, Peter.

Mov Disord ; 38(7): 1197-1208, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37195859

2.

A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls.

den Heijer, Jonas M; Cullen, Valerie C; Pereira, Diana R; Yavuz, Yalcin; de Kam, Marieke L; Grievink, Hendrika W; Moerland, Matthijs; Leymarie, Nancy; Khatri, Kshitij; Sollomoni, Imelda; Spitalny, Leslie; Dungeon, Lindsay; Hilt, Dana C; Justman, Craig; Lansbury, Peter; Groeneveld, Geert Jan.

Mov Disord ; 38(5): 783-795, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36916660

3.

A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.

den Heijer, Jonas M; Kruithof, Annelieke C; van Amerongen, Guido; de Kam, Marieke L; Thijssen, Eva; Grievink, Hendrika W; Moerland, Matthijs; Walker, Mike; Been, Kees; Skerlj, Renato; Justman, Craig; Dudgeon, Lindsay; Lansbury, Peter; Cullen, Valerie C; Hilt, Dana C; Groeneveld, Geert Jan.

Br J Clin Pharmacol ; 87(9): 3561-3573, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-33576113

4.

A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands.

den Heijer, Jonas M; Cullen, Valerie C; Quadri, Marialuisa; Schmitz, Arnoud; Hilt, Dana C; Lansbury, Peter; Berendse, Henk W; van de Berg, Wilma D J; de Bie, Rob M A; Boertien, Jeffrey M; Boon, Agnita J W; Contarino, M Fiorella; van Hilten, Jacobus J; Hoff, Jorrit I; van Mierlo, Tom; Munts, Alex G; van der Plas, Anne A; Ponsen, Mirthe M; Baas, Frank; Majoor-Krakauer, Danielle; Bonifati, Vincenzo; van Laar, Teus; Groeneveld, Geert J.

Mov Disord ; 35(9): 1667-1674, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32618053

5.

ß-Glucocerebrosidase Modulators Promote Dimerization of ß-Glucocerebrosidase and Reveal an Allosteric Binding Site.

Zheng, Jianbin; Chen, Long; Skinner, Owen S; Ysselstein, Daniel; Remis, Jonathan; Lansbury, Peter; Skerlj, Renato; Mrosek, Michael; Heunisch, Ursula; Krapp, Stephan; Charrow, Joel; Schwake, Michael; Kelleher, Neil L; Silverman, Richard B; Krainc, Dimitri.

J Am Chem Soc ; 140(18): 5914-5924, 2018 05 09.

Artigo em Inglês | MEDLINE | ID: mdl-29676907

6.

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier, Timothy J; Srivastava, Kinshuk R; Justman, Craig; Grammatopoulous, Tom; Hutter-Paier, Birgit; Prokesch, Manuela; Havas, Daniel; Rochet, Jean-Christophe; Liu, Fang; Jock, Kevin; de Oliveira, Patrícia; Stirtz, Georgia L; Dettmer, Ulf; Sortwell, Caryl E; Feany, Mel B; Lansbury, Peter; Lapidus, Lisa; Paumier, Katrina L.

Neurobiol Dis ; 106: 191-204, 2017 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-28711409

7.

The Jury Is Still Out.

Lansbury, Peter.

Mov Disord ; 37(3): 651, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35040206

8.

The Sphingolipids Clearly Play a Role in Parkinson's Disease, but Nature Has Made it Complicated.

Lansbury, Peter.

Mov Disord ; 37(10): 1985-1989, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36087026

9.

A century-old debate on protein aggregation and neurodegeneration enters the clinic.

Lansbury, Peter T; Lashuel, Hilal A.

Nature ; 443(7113): 774-9, 2006 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-17051203

10.

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.

Liu, Zhihua; Meray, Robin K; Grammatopoulos, Tom N; Fredenburg, Ross A; Cookson, Mark R; Liu, Yichin; Logan, Todd; Lansbury, Peter T.

Proc Natl Acad Sci U S A ; 106(12): 4635-40, 2009 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-19261853

11.

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice.

Cuddy, Leah K; Alia, Alia O; Salvo, Miranda A; Chandra, Sidhanth; Grammatopoulos, Tom N; Justman, Craig J; Lansbury, Peter T; Mazzulli, Joseph R; Vassar, Robert.

Mol Neurodegener ; 17(1): 54, 2022 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-35987691

12.

N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.

Vamvaca, Katherina; Lansbury, Peter T; Stefanis, Leonidas.

J Neurochem ; 119(2): 389-97, 2011 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21848810

13.

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.

Martinez-Vicente, Marta; Talloczy, Zsolt; Kaushik, Susmita; Massey, Ashish C; Mazzulli, Joseph; Mosharov, Eugene V; Hodara, Roberto; Fredenburg, Ross; Wu, Du-Chu; Follenzi, Antonia; Dauer, William; Przedborski, Serge; Ischiropoulos, Harry; Lansbury, Peter T; Sulzer, David; Cuervo, Ana Maria.

J Clin Invest ; 118(2): 777-88, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18172548

14.

Genetics of Parkinson's disease and biochemical studies of implicated gene products.

Lansbury, Peter T; Brice, Alexis.

Curr Opin Cell Biol ; 14(5): 653-60, 2002 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-12231362

15.

Back to the future: the 'old-fashioned' way to new medications for neurodegeneration.

Lansbury, Peter T.

Nat Med ; 10 Suppl: S51-7, 2004 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15298008

16.

False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance.

den Heijer, Jonas M; Schmitz, Arnoud; Lansbury, Peter; Cullen, Valerie C; Hilt, Dana C; Bonifati, Vincenzo; Groeneveld, Geert Jan.

Sci Rep ; 11(1): 161, 2021 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-33420335

17.

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.

Oliveira, Luis M A; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A; Sulzer, David; Vekrellis, Kostas; Halliday, Glenda M; Tomlinson, Julianna J; Schlossmacher, Michael; Jensen, Poul Henning; Schulze-Hentrich, Julia; Riess, Olaf; Hirst, Warren D; El-Agnaf, Omar; Mollenhauer, Brit; Lansbury, Peter; Outeiro, Tiago F.

NPJ Parkinsons Dis ; 7(1): 65, 2021 Jul 26.

Artigo em Inglês | MEDLINE | ID: mdl-34312398

18.

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.

Caputo, Samantha; Di Martino, Simona; Cilibrasi, Vincenzo; Tardia, Piero; Mazzonna, Marco; Russo, Debora; Penna, Ilaria; Summa, Maria; Bertozzi, Sine Mandrup; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Ottonello, Giuliana; Liu, Min; Lansbury, Peter; Armirotti, Andrea; Bertorelli, Rosalia; Ray, Soumya S; Skerlj, Renato; Scarpelli, Rita.

J Med Chem ; 63(24): 15821-15851, 2020 12 24.

Artigo em Inglês | MEDLINE | ID: mdl-33290061

19.

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.

Di Martino, Simona; Tardia, Piero; Cilibrasi, Vincenzo; Caputo, Samantha; Mazzonna, Marco; Russo, Debora; Penna, Ilaria; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Pizzirani, Daniela; Ottonello, Giuliana; Bertozzi, Sine Mandrup; Armirotti, Andrea; Nguyen, Duc; Sun, Ying; Bongarzone, Ernesto R; Lansbury, Peter; Liu, Min; Skerlj, Renato; Scarpelli, Rita.

J Med Chem ; 63(7): 3634-3664, 2020 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-32176488

20.

Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.

Cuddy, Leah K; Wani, Willayat Y; Morella, Martino L; Pitcairn, Caleb; Tsutsumi, Kotaro; Fredriksen, Kristina; Justman, Craig J; Grammatopoulos, Tom N; Belur, Nandkishore R; Zunke, Friederike; Subramanian, Aarthi; Affaneh, Amira; Lansbury, Peter T; Mazzulli, Joseph R.

Neuron ; 104(5): 869-884.e11, 2019 12 04.

Artigo em Inglês | MEDLINE | ID: mdl-31648898

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