Pityriasis Rubra Pilaris: A Multicentric Case Series of 65 Spanish Patients. / [Artículo traducido] Pitiriasis rubra pilaris: serie de casos multicéntrica de 65 pacientes españoles.

INTRODUCTION: PRP is a rare entity of unknown etiopathogenesis. Lack of management guidelines makes it a challenge for clinicians. OBJECTIVE: To add our experience to increase evidence about PRP. METHODS: We performed a retrospective, descriptive and multicentric study of 65 patients with PRP, being the largest European case series of patients with PRP. RESULTS: PRP was more frequent in male patients with an average age of 51 years, but erythrodermic forms presented in older patients (average age 61 years). Six (75%) paediatric patients and ten (60%) non-erythrodermic adults controlled their disease with topical corticosteroids. On the contrary, 26 (68%) erythrodermic patients required biologic therapy as last and effective therapy line requiring an average of 6.5 months to achieve complete response. CONCLUSION: Our study showed a statistical difference in terms of outcome and response to treatment between children or patients with limited disease and patients who develop erythroderma.

Pityriasis Rubra Pilaris: A Multicentric Case Series of 65 Spanish Patients.

INTRODUCTION: PRP is a rare entity of unknown etiopathogenesis. Lack of management guidelines makes it a challenge for clinicians. OBJECTIVE: To add our experience to increase evidence about PRP. METHODS: We performed a retrospective, descriptive and multicentric study of 65 patients with PRP, being the largest European case series of patients with PRP. RESULTS: PRP was more frequent in male patients with an average age of 51 years, but erythrodermic forms presented in older patients (average age 61 years). Six (75%) paediatric patients and ten (60%) non-erythrodermic adults controlled their disease with topical corticosteroids. On the contrary, 26 (68%) erythrodermic patients required biologic therapy as last and effective therapy line requiring an average of 6.5 months to achieve complete response. CONCLUSION: Our study showed a statistical difference in terms of outcome and response to treatment between children or patients with limited disease and patients who develop erythroderma.

[Secondary effects of topical application of an essential oil. Allergic contact dermatitis due to tea tree oil]. / Efectos secundarios de la aplicación tópica de un aceite de esencial. Dermatitis alérgica de contacto a aceite de árbol de té.

BACKGROUND: Tea tree oil is an essential oil, whose use is increasing in our setting, due both to its supposed medicinal effects and to its aromatic properties. We describe our experience with allergic contact dermatitis following the application of this oil. MATERIAL AND METHODS: Five patients in the last 5 years (0.4% of all the patients studied in specialized consultation) reacted to a 5% concentration of tea tree oil in Vaseline. RESULTS: All the patients presented strong reactions, and in all cases these were considered relevant. Three of them also reacted to oxidized d-limonene, one of the components of tea tree oil, which is present in our standard series. CONCLUSIONS: Different cases have been described in the literature on allergic contact dermatitis due to tea tree oil, but until recently it was infrequent in our setting. With the increased popularity of alternative and natural therapies we have witnessed several cases of sensitization to this essential oil, which had been used to treat several supposedly "infectious" skin diseases, but which were very probably different forms of dermatitis.

[Lip eczema. Experience in the Contact Dermatitis Unit of a Spanish tertiary hospital]. / Eccema de labios. Experiencia en la Unidad de Eccema de Contacto de un centro terciario español.

BACKGROUND: Lip eczema is an infrequent problem in Contact Dermatitis Units (CDU). Very few series have been published to date that show the profiles of such patients and the causes of their eczemas, and none are Spanish. The goal of this study was to analyze the epidemiological profile of the patients who attend a CDU in our setting, the main diagnoses and the relevant allergens. METHODS: A retrospective review was made of the patients referred to the CDU in the 2005-2014 period. Patch tests were carried out with the extended standard series of the Spanish Research Group on Allergic Contact Dermatitis (Grupo Español de Investigación en Dermatitis Alérgica de contacto - GEIDAC), our own products and other complementary sets. RESULTS: The most frequent diagnoses in the 78 patients studied were allergic contact dermatitis and atopic dermatitis. The most frequent relevant allergens were cosmetics and topical medications. CONCLUSIONS: It is essential to study the patients with lip eczema with patch tests to be able to correctly determine their etiology and accordingly to carry out the most suitable treatment.