Detalhe da pesquisa
1.
Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
Mov Disord
; 34(5): 708-716, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30575996
2.
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor.
Proc Natl Acad Sci U S A
; 113(41): E6145-E6152, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671624
3.
Pridopidine activates neuroprotective pathways impaired in Huntington Disease.
Hum Mol Genet
; 25(18): 3975-3987, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466197
4.
Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide.
J Pept Sci
; 20(1): 7-19, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24222478
5.
Focal lesions following intracerebral gene therapy for mucopolysaccharidosis IIIA.
Ann Clin Transl Neurol
; 10(6): 904-917, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37165777
6.
Design of a stable human acid-ß-glucosidase: towards improved Gaucher disease therapy and mutation classification.
FEBS J
; 290(13): 3383-3399, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808692
7.
PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes.
Bioorg Med Chem
; 20(15): 4751-9, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22771182
8.
Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice.
PLoS One
; 17(3): e0265749, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35316287
9.
AAV-delivered diacylglycerol kinase DGKk achieves long-term rescue of fragile X syndrome mouse model.
EMBO Mol Med
; 14(5): e14649, 2022 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35373916
10.
AAVrh10 vector corrects pathology in animal models of GM1 gangliosidosis and achieves widespread distribution in the CNS of nonhuman primates.
Mol Ther Methods Clin Dev
; 27: 281-292, 2022 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36320411
11.
AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains.
Mol Ther Methods Clin Dev
; 17: 174-187, 2020 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31909089
12.
Quantitative prediction of human clearance guiding the development of Raltegravir (MK-0518, isentress) and related HIV integrase inhibitors.
Drug Metab Dispos
; 37(4): 873-83, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144773
13.
Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 19(5): 1392-5, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181520
14.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18217703
15.
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett
; 18(23): 6078-82, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952417
16.
Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
J Med Chem
; 50(9): 2225-39, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428043
17.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17824681
18.
Pharmacogenomics strategies to optimize treatments for multiple sclerosis: Insights from clinical research.
Prog Neurobiol
; 152: 114-130, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26952809
19.
4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
J Med Chem
; 49(23): 6646-9, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154493
20.
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.
J Med Chem
; 49(18): 5404-7, 2006 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16942012