Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Autocrine vitamin D signaling switches off pro-inflammatory programs of T_H1 cells.

Chauss, Daniel; Freiwald, Tilo; McGregor, Reuben; Yan, Bingyu; Wang, Luopin; Nova-Lamperti, Estefania; Kumar, Dhaneshwar; Zhang, Zonghao; Teague, Heather; West, Erin E; Vannella, Kevin M; Ramos-Benitez, Marcos J; Bibby, Jack; Kelly, Audrey; Malik, Amna; Freeman, Alexandra F; Schwartz, Daniella M; Portilla, Didier; Chertow, Daniel S; John, Susan; Lavender, Paul; Kemper, Claudia; Lombardi, Giovanna; Mehta, Nehal N; Cooper, Nichola; Lionakis, Michail S; Laurence, Arian; Kazemian, Majid; Afzali, Behdad.

Nat Immunol ; 23(1): 62-74, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34764490

2.

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.

Kolev, Martin; West, Erin E; Kunz, Natalia; Chauss, Daniel; Moseman, E Ashley; Rahman, Jubayer; Freiwald, Tilo; Balmer, Maria L; Lötscher, Jonas; Dimeloe, Sarah; Rosser, Elizabeth C; Wedderburn, Lucy R; Mayer-Barber, Katrin D; Bohrer, Andrea; Lavender, Paul; Cope, Andrew; Wang, Luopin; Kaplan, Mariana J; Moutsopoulos, Niki M; McGavern, Dorian; Holland, Steven M; Hess, Christoph; Kazemian, Majid; Afzali, Behdad; Kemper, Claudia.

Immunity ; 52(3): 513-527.e8, 2020 03 17.

Artigo em Inglês | MEDLINE | ID: mdl-32187519

3.

NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression.

Switzer, Christopher H; Cho, Hyun-Ju; Eykyn, Thomas R; Lavender, Paul; Eaton, Philip.

Proc Natl Acad Sci U S A ; 119(21): e2200022119, 2022 05 24.

Artigo em Inglês | MEDLINE | ID: mdl-35584114

4.

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.

Kolev, Martin; Dimeloe, Sarah; Le Friec, Gaelle; Navarini, Alexander; Arbore, Giuseppina; Povoleri, Giovanni A; Fischer, Marco; Belle, Réka; Loeliger, Jordan; Develioglu, Leyla; Bantug, Glenn R; Watson, Julie; Couzi, Lionel; Afzali, Behdad; Lavender, Paul; Hess, Christoph; Kemper, Claudia.

Immunity ; 42(6): 1033-47, 2015 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-26084023

5.

Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis.

Kim, Sangmi; Boehme, Lena; Nel, Louise; Casian, Alina; Sangle, Shirish; Nova-Lamperti, Estefania; Seitan, Vlad; Spencer, Jo; Lavender, Paul; D'Cruz, David P; John, Susan.

J Immunol ; 208(4): 807-818, 2022 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-35039330

6.

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4⁺ T Cells.

Ridley, Michael L; Fleskens, Veerle; Roberts, Ceri A; Lalnunhlimi, Sylvine; Alnesf, Aldana; O'Byrne, Aoife M; Steel, Kathryn J A; Povoleri, Giovanni A M; Sumner, Jonathan; Lavender, Paul; Taams, Leonie S.

J Immunol ; 204(11): 2940-2948, 2020 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-32321757

7.

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

Powell, Nick; Pantazi, Eirini; Pavlidis, Polychronis; Tsakmaki, Anastasia; Li, Katherine; Yang, Feifei; Parker, Aimee; Pin, Carmen; Cozzetto, Domenico; Minns, Danielle; Stolarczyk, Emilie; Saveljeva, Svetlana; Mohamed, Rami; Lavender, Paul; Afzali, Behdad; Digby-Bell, Jonathan; Tjir-Li, Tsui; Kaser, Arthur; Friedman, Joshua; MacDonald, Thomas T; Bewick, Gavin A; Lord, Graham M.

Gut ; 69(3): 578-590, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31792136

8.

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α.

Goldberg, Rimma; Scotta, Cristiano; Cooper, Dianne; Nissim-Eliraz, Einat; Nir, Eilam; Tasker, Scott; Irving, Peter M; Sanderson, Jeremy; Lavender, Paul; Ibrahim, Fowzia; Corcoran, Jonathan; Prevost, Toby; Shpigel, Nahum Y; Marelli-Berg, Federica; Lombardi, Giovanna; Lord, Graham M.

Gastroenterology ; 156(6): 1775-1787, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30710527

9.

SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.

Correia, Lúcia L; Johnson, Jo-Anne; McErlean, Peter; Bauer, Julien; Farah, Hassan; Rassl, Doris M; Rintoul, Robert C; Sethi, Tariq; Lavender, Paul; Rawlins, Emma L; Littlewood, Trevor D; Evan, Gerard I; McCaughan, Frank M.

Am J Respir Crit Care Med ; 195(11): 1494-1508, 2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28199128

10.

Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis.

Shankar-Hari, Manu; Fear, David; Lavender, Paul; Mare, Tracey; Beale, Richard; Swanson, Chad; Singer, Mervyn; Spencer, Jo.

Crit Care Med ; 45(5): 875-882, 2017 May.

Artigo em Inglês | MEDLINE | ID: mdl-28296810

11.

Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1ß-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes.

Wang, Yufei; Lavender, Paul; Watson, Julie; Arno, Matthew; Lehner, Thomas.

J Biol Chem ; 290(25): 15595-15609, 2015 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-25907558

12.

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.

Stott, Bryony; Lavender, Paul; Lehmann, Sarah; Pennino, Davide; Durham, Stephen; Schmidt-Weber, Carsten B.

J Allergy Clin Immunol ; 132(2): 446-54.e5, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23694808

13.

Epigenetic Approaches to Identifying Asthma Endotypes.

Kelly, Audrey; Lavender, Paul.

Allergy Asthma Immunol Res ; 16(2): 130-141, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38528381

14.

DNA methylation modules in airway smooth muscle are associated with asthma severity.

Perry, Mark M; Lavender, Paul; Kuo, Chih-Hsi Scott; Galea, Francesca; Michaeloudes, Charalambos; Flanagan, James M; Fan Chung, Kian; Adcock, Ian M.

Eur Respir J ; 51(4)2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29449426

15.

IL-2 regulates expression of C-MAF in human CD4 T cells.

Rani, Aradhana; Afzali, Behdad; Kelly, Audrey; Tewolde-Berhan, Lemlem; Hackett, Mark; Kanhere, Aditi S; Pedroza-Pacheco, Isabela; Bowen, Holly; Jurcevic, Stipo; Jenner, Richard G; Cousins, David J; Ragheb, Jack A; Lavender, Paul; John, Susan.

J Immunol ; 187(7): 3721-9, 2011 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-21876034

16.

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.

Villiers, William; Kelly, Audrey; He, Xiaohan; Kaufman-Cook, James; Elbasir, Abdurrahman; Bensmail, Halima; Lavender, Paul; Dillon, Richard; Mifsud, Borbála; Osborne, Cameron S.

Nat Commun ; 14(1): 724, 2023 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-36759620

17.

MicroRNAs in lung diseases.

Pagdin, Tom; Lavender, Paul.

Thorax ; 67(2): 183-4, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21836155

18.

Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping.

Yao, Xin; Zha, Wangjian; Song, Wei; He, Haiyan; Huang, Mao; Jazrawi, Elen; Lavender, Paul; Barnes, Peter J; Adcock, Ian M; Durham, Andrew L.

Biochem Biophys Res Commun ; 417(3): 996-1001, 2012 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-22226971

19.

Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.

Mahn, Katharina; Hirst, Stuart J; Ying, Sun; Holt, Mark R; Lavender, Paul; Ojo, Oluwaseun O; Siew, Leonard; Simcock, David E; McVicker, Clare G; Kanabar, Varsha; Snetkov, Vladimir A; O'Connor, Brian J; Karner, Charlotta; Cousins, David J; Macedo, Patricia; Chung, K Fan; Corrigan, Christopher J; Ward, Jeremy P T; Lee, Tak H.

Proc Natl Acad Sci U S A ; 106(26): 10775-80, 2009 Jun 30.

Artigo em Inglês | MEDLINE | ID: mdl-19541629

20.

Quantitative assessment of NFκB transcription factor activity.

Hunter, Terrence T J; Fear, David; Lavender, Paul; Spencer, Jo; Peakman, Mark; Ibrahim, Mohammad A A.

J Immunol Methods ; 492: 112954, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33388338

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