Assuntos
Fotoquimioterapia , Dermatopatias Parasitárias/tratamento farmacológico , Dermatopatias Virais/tratamento farmacológico , Dermatologia/educação , Educação Médica Continuada , Humanos , Leishmaniose Cutânea/tratamento farmacológico , Infecções por Papillomavirus/tratamento farmacológico , Protoporfirinas/biossínteseRESUMO
BACKGROUND: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. METHODS: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. RESULTS: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. CONCLUSION: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.
Assuntos
Neoplasias do Ânus/patologia , Carcinoma de Células Escamosas/patologia , Hidradenite Supurativa/patologia , Papillomavirus Humano 16 , Infecções por Papillomavirus/patologia , Neoplasias Urogenitais/patologia , Adolescente , Adulto , Neoplasias do Ânus/complicações , Neoplasias do Ânus/virologia , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/virologia , Carcinoma Verrucoso/complicações , Carcinoma Verrucoso/patologia , Carcinoma Verrucoso/virologia , Transformação Celular Neoplásica/patologia , Feminino , Hidradenite Supurativa/complicações , Hidradenite Supurativa/virologia , Humanos , Masculino , Infecções por Papillomavirus/complicações , Estudos Retrospectivos , Fumar/efeitos adversos , Neoplasias Urogenitais/complicações , Neoplasias Urogenitais/virologia , Adulto JovemRESUMO
INTRODUCTION: Takayasu arteritis (TA) is an inflammatory arteritis affecting large vessels, predominantly the aorta, its main branches, and the pulmonary arteries. Up to now, arteriography was considered as the "gold standard". But others exams are emerging in the management of TA: vascular ultrasound, angio-scanner, magnetic resonance imaging and 18FDG positron emission tomography (18FDG PET). Such investigations allow a study of the lumen but also of the arterial walls. However, at the time, no biological or radiological test is able to determine the activity of TA. 18FDG PET could be effective to estimate the disease activity. EXEGESIS: We report the case of a young woman for who 18FDG PET permit to assert a relapse of TA. CONCLUSION: 18FDG PET could be effective to estimate the disease activity.