Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

Miao, Edward A; Leaf, Irina A; Treuting, Piper M; Mao, Dat P; Dors, Monica; Sarkar, Anasuya; Warren, Sarah E; Wewers, Mark D; Aderem, Alan.

Nat Immunol ; 11(12): 1136-42, 2010 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-21057511

2.

Interleukin-1ß Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.

Lemos, Dario R; McMurdo, Michael; Karaca, Gamze; Wilflingseder, Julia; Leaf, Irina A; Gupta, Navin; Miyoshi, Tomoya; Susa, Koichiro; Johnson, Bryce G; Soliman, Kirolous; Wang, Guanghai; Morizane, Ryuji; Bonventre, Joseph V; Duffield, Jeremy S.

J Am Soc Nephrol ; 29(6): 1690-1705, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29739813

3.

What can target kidney fibrosis?

Leaf, Irina A; Duffield, Jeremy S.

Nephrol Dial Transplant ; 32(suppl_1): i89-i97, 2017 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-28391346

4.

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.

Miao, Edward A; Mao, Dat P; Yudkovsky, Natalya; Bonneau, Richard; Lorang, Cynthia G; Warren, Sarah E; Leaf, Irina A; Aderem, Alan.

Proc Natl Acad Sci U S A ; 107(7): 3076-80, 2010 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-20133635

5.

Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

Warren, Sarah E; Armstrong, Abraham; Hamilton, M Kristina; Mao, Dat P; Leaf, Irina A; Miao, Edward A; Aderem, Alan.

J Immunol ; 185(2): 818-21, 2010 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-20562263

6.

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.

Puranik, Amrutesh S; Leaf, Irina A; Jensen, Mark A; Hedayat, Ahmad F; Saad, Ahmad; Kim, Ki-Wook; Saadalla, Abdulrahman M; Woollard, John R; Kashyap, Sonu; Textor, Stephen C; Grande, Joseph P; Lerman, Amir; Simari, Robert D; Randolph, Gwendalyn J; Duffield, Jeremy S; Lerman, Lilach O.

Sci Rep ; 8(1): 13948, 2018 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-30224726

7.

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Leaf, Irina A; Nakagawa, Shunsaku; Johnson, Bryce G; Cha, Jin Joo; Mittelsteadt, Kristen; Guckian, Kevin M; Gomez, Ivan G; Altemeier, William A; Duffield, Jeremy S.

J Clin Invest ; 127(1): 321-334, 2017 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-27869651

8.

Canonical Inflammasomes Drive IFN-Î³ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

Aachoui, Youssef; Kajiwara, Yuji; Leaf, Irina A; Mao, Dat; Ting, Jenny P-Y; Coers, Jörn; Aderem, Alan; Buxbaum, Joseph D; Miao, Edward A.

Cell Host Microbe ; 18(3): 320-32, 2015 Sep 09.

Artigo em Inglês | MEDLINE | ID: mdl-26320999

9.

Caspase-11 protects against bacteria that escape the vacuole.

Aachoui, Youssef; Leaf, Irina A; Hagar, Jon A; Fontana, Mary F; Campos, Cristine G; Zak, Daniel E; Tan, Michael H; Cotter, Peggy A; Vance, Russell E; Aderem, Alan; Miao, Edward A.

Science ; 339(6122): 975-8, 2013 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-23348507

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