Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Topical treatment of actinic keratoses in organ transplant recipients: a feasibility study for SPOT (Squamous cell carcinoma Prevention in Organ transplant recipients using Topical treatments).

Hasan, Zeeshaan-Ul; Ahmed, Ikhlaaq; Matin, Rubeta N; Homer, Victoria; Lear, John T; Ismail, Ferina; Whitmarsh, Tristan; Green, Adele C; Thomson, Jason; Milligan, Alan; Hogan, Sarah; Van-de-Velde, Vanessa; Mitchell-Worsford, Liza; Kentley, Jonathan; Gaunt, Claire; Jefferson-Hulme, Yolande; Bowden, Sarah J; Gaunt, Piers; Wheatley, Keith; Proby, Charlotte M; Harwood, Catherine A.

Br J Dermatol ; 187(3): 324-337, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-34988975

2.

Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome.

Liu, Yanshan; Banka, Siddharth; Huang, Yingzhi; Hardman-Smart, Jonathan; Pye, Derek; Torrelo, Antonio; Beaman, Glenda M; Kazanietz, Marcelo G; Baker, Martin J; Ferrazzano, Carlo; Shi, Chenfu; Orozco, Gisela; Eyre, Stephen; van Geel, Michel; Bygum, Anette; Fischer, Judith; Miedzybrodzka, Zosia; Abuzahra, Faris; Rübben, Albert; Cuvertino, Sara; Ellingford, Jamie M; Smith, Miriam J; Evans, D Gareth; Weppner-Parren, Lizelotte J M T; van Steensel, Maurice A M; Chaudhary, Iskander H; Mangham, D Chas; Lear, John T; Paus, Ralf; Frank, Jorge; Newman, William G; Zhang, Xue.

Br J Dermatol ; 187(6): 948-961, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-35986704

3.

Clinicopathological characteristics of individuals with coexisting melanoma and chronic lymphocytic leukaemia: a multicentre cohort study.

Fisher, Rachel Mary; Ji-Xu, Antonio; Abbott, Rachel; Basu, Tanya; Brown, Alistair; Foley, Catherine; Glen, Catriona; Gupta, Girish; Hasan, Zeeshaan; Ismail, Ferina; Khalid, Amina; Khoo, Andre B S; Koumaki, Dimitra; Lally, Aoife; Lear, John T; McGrath, Emily Jane; McKenna, Kein; Milligan, Alan; Mulholland, Orlagh; Tasker, Fiona; Harwood, Catherine A; Proby, Charlotte M; Matin, Rubeta N.

Clin Exp Dermatol ; 47(11): 1976-1981, 2022 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35801421

4.

First evidence of genotype-phenotype correlations in Gorlin syndrome.

Evans, D Gareth; Oudit, Deemesh; Smith, Miriam J; Rutkowski, David; Allan, Ernest; Newman, William G; Lear, John T.

J Med Genet ; 54(8): 530-536, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28596197

5.

Managing adverse events associated with vismodegib in the treatment of basal cell carcinoma.

Fife, Kate; Herd, Robert; Lalondrelle, Susan; Plummer, Ruth; Strong, Amy; Jones, Sarah; Lear, John T.

Future Oncol ; 13(2): 175-184, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27640448

6.

A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity.

Dréno, Brigitte; Cerio, Rino; Dirschka, Thomas; Nart, Ignasi Figueras; Lear, John T; Peris, Ketty; de Casas, Andrés Ruiz; Kaleci, Shaniko; Pellacani, Giovanni.

Acta Derm Venereol ; 97(9): 1108-1113, 2017 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-28536731

7.

Defining locally advanced basal cell carcinoma and integrating smoothened inhibitors into clinical practice.

Khoo, Andre B S; Ali, Faisal R; Lear, John T.

Curr Opin Oncol ; 28(2): 180-4, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26780190

8.

Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes With LDE225 Treatment (BOLT) trial at 42 months.

Dummer, Reinhard; Lear, John T; Guminski, Alex; Leow, Liang Joo; Squittieri, Nicholas; Migden, Michael.

J Am Acad Dermatol ; 84(4): 1162-1164, 2021 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-33358380

9.

The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.

Dummer, Reinhard; Guminski, Alexander; Gutzmer, Ralf; Dirix, Luc; Lewis, Karl D; Combemale, Patrick; Herd, Robert M; Kaatz, Martin; Loquai, Carmen; Stratigos, Alexander J; Schulze, Hans-Joachim; Plummer, Ruth; Gogov, Sven; Pallaud, Celine; Yi, Tingting; Mone, Manisha; Chang, Anne Lynn S; Cornélis, Frank; Kudchadkar, Ragini; Trefzer, Uwe; Lear, John T; Sellami, Dalila; Migden, Michael R.

J Am Acad Dermatol ; 75(1): 113-125.e5, 2016 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-27067394

10.

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

Migden, Michael R; Guminski, Alexander; Gutzmer, Ralf; Dirix, Luc; Lewis, Karl D; Combemale, Patrick; Herd, Robert M; Kudchadkar, Ragini; Trefzer, Uwe; Gogov, Sven; Pallaud, Celine; Yi, Tingting; Mone, Manisha; Kaatz, Martin; Loquai, Carmen; Stratigos, Alexander J; Schulze, Hans-Joachim; Plummer, Ruth; Chang, Anne Lynn S; Cornélis, Frank; Lear, John T; Sellami, Dalila; Dummer, Reinhard.

Lancet Oncol ; 16(6): 716-28, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25981810

11.

Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK.

Wallingford, Sarah C; Russell, Sheila A; Vail, Andy; Proby, Charlotte M; Lear, John T; Green, Adèle C.

Acta Derm Venereol ; 95(7): 830-4, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25784002

12.

Pharmacokinetics and pharmacodynamics of Hedgehog pathway inhibitors used in the treatment of advanced or treatment-refractory basal cell carcinoma.

Lear, John T; Morris, Linda M; Ness, Dylan B; Lewis, Lionel D.

Expert Rev Clin Pharmacol ; 16(12): 1211-1220, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37975712

13.

Concomitant medication use does not appear to alter long-term efficacy of sonidegib for advanced basal cell carcinoma: a post hoc analysis based on the 42-month BOLT study.

Lear, John T; Robert, Caroline; Grob, Jean-Jacques; Dummer, Reinhard; Guminski, Alexander; Squittieri, Nicholas; Migden, Michael.

Eur J Dermatol ; 33(3): 280-286, 2023 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-37594336

14.

Actinic Keratosis, a Chronic, Progressive Disease: Understanding Clinical Gaps to Optimise Patient Management.

Cerio, Rino; Dirschka, Thomas; Dréno, Brigitte; Figueras Nart, Ignasi; Lear, John T; Pellacani, Giovanni; Peris, Ketty; de Casas, Andrés Ruiz.

Acta Derm Venereol ; 97(8): 997-998, 2017 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-28448101

15.

What lies beneath actinic keratosis? Looking beyond visible lesions to optimize patient outcomes.

Lear, John T.

J Eur Acad Dermatol Venereol ; 31 Suppl 2: 3-4, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-28263019

16.

A Real-World Data Study on the Healthcare Resource Use for Uncontrolled Moderate-to-Severe Atopic Dermatitis in Secondary Care in the United Kingdom Prior to the Introduction of Biologic Treatment.

Hudson, Richard D A; Ameen, Mahreen; George, Susannah M C; Harwood, Catherine A; Weller, Richard B; Lear, John T; Rout, Rajesh; Surendranathan, Thishi; Petrovic, Milos; Bewley, Anthony P.

Clinicoecon Outcomes Res ; 14: 167-177, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35399649

17.

Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial.

Smith, Isabelle L; Gilberts, Rachael; Brown, Sarah; Fernandez, Catherine; Nixon, Jane; Reynolds, Catherine; Smith, Catherine; Lear, John T; Sunderland, Lesley; Green, Cathy; Goodfield, Mark; Cowdell, Fiona; Hampton, Philip; Barker, Amy; Vargas-Palacios, Armando; Tubeuf, Sandy; Wittmann, Miriam.

BMJ Open ; 12(2): e060029, 2022 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-35197358

18.

Non-melanoma skin cancer.

Madan, Vishal; Lear, John T; Szeimies, Rolf-Markus.

Lancet ; 375(9715): 673-85, 2010 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-20171403

19.

Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma.

Lear, John T; Dummer, Reinhard; Guminski, Alexander.

Oncotarget ; 12(26): 2531-2540, 2021 Dec 21.

Artigo em Inglês | MEDLINE | ID: mdl-34966484

20.

Oral hedgehog-pathway inhibitors for basal-cell carcinoma.