RESUMO
A high performance liquid-chromatographic procedure is reported for measuring the plasma concentration of 5 anticonvulsants: phenobarbital, phenytoin, carbamazepine, ethosuximide, valproic acid and 2 bronchodilators: theophylline and caffeine. Limits of detection of ethosuximide and valproic acid are 28 mumol/l, 5 mumol/l for the other drugs. Linearity limits are always very upper than the higher therapeutic dose concentration, the inter assay relative standard deviation are less than 8 p. cent for the 7 drugs at the 3 levels of concentration and the analytical recoveries ranged from 93 to 104 p. cent. The technique is simple and rapid: 4 anticonvulsants are simultaneously extracted and dosed, valproic acid, only has to be dosed lonely. Finally, comparatively to the other immunoassay technique, this method is cheaper.
Assuntos
Anticonvulsivantes/sangue , Broncodilatadores/sangue , Cafeína/sangue , Carbamazepina/sangue , Cromatografia Líquida de Alta Pressão , Etossuximida/sangue , Fenobarbital/sangue , Fenitoína/sangue , Teofilina/sangue , Ácido Valproico/sangueRESUMO
Complex choristomas are very rare ocular tumors. We report a case of a 3-month-old infant who was referred to us because of a left congenital conjunctivo-corneal protruding mass. Total excision removing 2/3 of the limbus was performed and replaced simultaneously by a limbal autograft. Histopathological examination of the excised choristoma revealed many pilosebaceous follicules in the conjunctival tissue, keratinized epithelium, lacrimal glands, and differentiated cartilage.