Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Zheng, Yuxiang; Lin, Ting-Yu; Lee, Gina; Paddock, Marcia N; Momb, Jessica; Cheng, Zhe; Li, Qian; Fei, Dennis L; Stein, Benjamin D; Ramsamooj, Shivan; Zhang, Guoan; Blenis, John; Cantley, Lewis C.

Cell ; 175(6): 1546-1560.e17, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500537

2.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John.

Cell ; 171(7): 1545-1558.e18, 2017 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-29153836

3.

The picky mTORC1 in metabolic enzyme degradation.

Chun, Yujin; Fruman, David A; Lee, Gina.

Mol Cell ; 84(11): 2011-2013, 2024 Jun 06.

Artigo em Inglês | MEDLINE | ID: mdl-38848689

4.

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Cho, Sungyun; Chun, Yujin; He, Long; Ramirez, Cuauhtemoc B; Ganesh, Kripa S; Jeong, Kyungjo; Song, Junho; Cheong, Jin Gyu; Li, Zhongchi; Choi, Jungmin; Kim, Joohwan; Koundouros, Nikos; Ding, Fangyuan; Dephoure, Noah; Jang, Cholsoon; Blenis, John; Lee, Gina.

Mol Cell ; 83(16): 3010-3026.e8, 2023 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-37595559

5.

mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.

Cho, Sungyun; Lee, Gina; Pickering, Brian F; Jang, Cholsoon; Park, Jin H; He, Long; Mathur, Lavina; Kim, Seung-Soo; Jung, Sunhee; Tang, Hong-Wen; Monette, Sebastien; Rabinowitz, Joshua D; Perrimon, Norbert; Jaffrey, Samie R; Blenis, John.

Mol Cell ; 81(10): 2064-2075.e8, 2021 05 20.

Artigo em Inglês | MEDLINE | ID: mdl-33756105

6.

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

He, Long; Gomes, Ana P; Wang, Xin; Yoon, Sang Oh; Lee, Gina; Nagiec, Michal J; Cho, Sungyun; Chavez, Andre; Islam, Tasnia; Yu, Yonghao; Asara, John M; Kim, Bo Yeon; Blenis, John.

Mol Cell ; 70(5): 949-960.e4, 2018 06 07.

Artigo em Inglês | MEDLINE | ID: mdl-29861159

7.

Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.

Park, Jin H; Lee, Gina; Blenis, John.

Trends Biochem Sci ; 45(5): 367-369, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32311329

8.

MAPK13 stabilization via m⁶A mRNA modification limits anticancer efficacy of rapamycin.

Kim, Joohwan; Chun, Yujin; Ramirez, Cuauhtemoc B; Hoffner, Lauren A; Jung, Sunhee; Jang, Ki-Hong; Rubtsova, Varvara I; Jang, Cholsoon; Lee, Gina.

J Biol Chem ; 299(9): 105175, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37599001

9.

Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.

Hyun, Seogang; Lee, Jung Hyun; Jin, Hua; Nam, JinWu; Namkoong, Bumjin; Lee, Gina; Chung, Jongkyeong; Kim, V Narry.

Cell ; 139(6): 1096-108, 2009 Dec 11.

Artigo em Inglês | MEDLINE | ID: mdl-20005803

10.

mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy.

Tang, Hong-Wen; Weng, Jui-Hsia; Lee, Wen Xing; Hu, Yanhui; Gu, Lei; Cho, Sungyun; Lee, Gina; Binari, Richard; Li, Cathleen; Cheng, Min En; Kim, Ah-Ram; Xu, Jun; Shen, Zhangfei; Xu, Chiwei; Asara, John M; Blenis, John; Perrimon, Norbert.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-33649236

11.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada, Shogo; Neinast, Michael; Jang, Cholsoon; Ibrahim, Yasir H; Lee, Gina; Babu, Apoorva; Li, Jian; Hoshino, Atsushi; Rowe, Glenn C; Rhee, James; Martina, José A; Puertollano, Rosa; Blenis, John; Morley, Michael; Baur, Joseph A; Seale, Patrick; Arany, Zoltan.

Genes Dev ; 30(22): 2551-2564, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27913603

12.

Effectiveness of Messenger RNA-1273 Vaccine Booster Against Coronavirus Disease 2019 in Immunocompetent Adults.

Florea, Ana; Sy, Lina S; Qian, Lei; Ackerson, Bradley K; Luo, Yi; Tubert, Julia E; Lee, Gina S; Ku, Jennifer H; Bruxvoort, Katia J; Talarico, Carla A; Qiu, Sijia; Tian, Yun; Tseng, Hung Fu.

Clin Infect Dis ; 76(2): 252-262, 2023 01 13.

Artigo em Inglês | MEDLINE | ID: mdl-36134518

13.

Left Atrial Phasic Function in Older Adults Is Associated with Fibrotic and Low-Grade Inflammatory Pathways.

Koh, Angela S; Siau, Anthony; Gao, Fei; Chioh, Florence W J; Leng, Shuang; Zhao, Xiaodan; Zhong, Liang; Tan, Ru San; Koh, Poh Ling; Kovalik, Jean-Paul; Lim, Wee Shiong; Lee, Gina S; Koh, Woon-Puay; Cheung, Christine.

Gerontology ; 69(1): 47-56, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-35316808

14.

The bidirectional relationship between depressive symptoms and functional limitations among centenarian survivors in their 80s: Testing bivariate latent change score models.

Lee, Gina; Arieli, Rotem; Ryou, Yeon Ji; Martin, Peter.

Aging Ment Health ; 27(9): 1720-1728, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-36786734

15.

Cognitive Reserve and Cognitive Functioning among Oldest Old Adults: Findings from the Georgia Centenarian Study.

Martin, Peter; Gondo, Yasuyuki; Lee, Gina; Woodard, John L; Miller, L Steven; Poon, Leonard W.

Exp Aging Res ; 49(4): 334-346, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-35929967

16.

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.

Shireman, Jack M; Atashi, Fatemeh; Lee, Gina; Ali, Eunus S; Saathoff, Miranda R; Park, Cheol H; Savchuk, Sol; Baisiwala, Shivani; Miska, Jason; Lesniak, Maciej S; James, C David; Stupp, Roger; Kumthekar, Priya; Horbinski, Craig M; Ben-Sahra, Issam; Ahmed, Atique U.

Brain ; 144(4): 1230-1246, 2021 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-33855339

17.

Akt-ivation of RNA splicing.

Lee, Gina; Blenis, John.

Mol Cell ; 53(4): 519-20, 2014 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-24560271

18.

Effect of psychosocial motivations and technology on physical activity behaviours among community older men and women.

Lee, Yong Lin; Lee, Gina S; Teo, Louis Ly; Tan, Ru-San; Zhong, Liang; Gao, Fei; Koh, Angela S.

BMC Geriatr ; 22(1): 933, 2022 12 03.

Artigo em Inglês | MEDLINE | ID: mdl-36463121

19.

Constraint-induced movement therapy for children with neonatal brachial plexus palsy: a randomized crossover trial.

Werner, Julie M; Berggren, Jamie; Loiselle, Jennifer; Lee, Gina Kim.

Dev Med Child Neurol ; 63(5): 545-551, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33219706

20.

The use of natural language processing to identify vaccine-related anaphylaxis at five health care systems in the Vaccine Safety Datalink.

Yu, Wei; Zheng, Chengyi; Xie, Fagen; Chen, Wansu; Mercado, Cheryl; Sy, Lina S; Qian, Lei; Glenn, Sungching; Tseng, Hung F; Lee, Gina; Duffy, Jonathan; McNeil, Michael M; Daley, Matthew F; Crane, Brad; McLean, Huong Q; Jackson, Lisa A; Jacobsen, Steven J.

Pharmacoepidemiol Drug Saf ; 29(2): 182-188, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31797475

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