Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu, Jaspreet; Li, Shiqian; Fairall, Louise; Pfisterer, Simon G; Gurnett, Jennifer E; Xiao, Xu; Weston, Thomas A; Vashi, Dipti; Ferrari, Alessandra; Orozco, Jose L; Hartman, Celine L; Strugatsky, David; Lee, Stephen D; He, Cuiwen; Hong, Cynthia; Jiang, Haibo; Bentolila, Laurent A; Gatta, Alberto T; Levine, Tim P; Ferng, Annie; Lee, Richard; Ford, David A; Young, Stephen G; Ikonen, Elina; Schwabe, John W R; Tontonoz, Peter.

Cell ; 175(2): 514-529.e20, 2018 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-30220461

2.

Eosinophils in fat: pink is the new brown.

Lee, Stephen D; Tontonoz, Peter.

Cell ; 157(6): 1249-1250, 2014 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-24906141

3.

Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway.

Priest, Christina; Nagari, Rohith T; Bideyan, Lara; Lee, Stephen D; Nguyen, Alexander; Xiao, Xu; Tontonoz, Peter.

Proc Natl Acad Sci U S A ; 119(18): e2201859119, 2022 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-35476518

4.

Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.

Lee, Stephen D; Song, Jungeun; LeBlanc, Veronique G; Marra, Marco A.

J Pathol ; 256(3): 297-309, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-34767259

5.

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.

Calkin, Anna C; Lee, Stephen D; Kim, Jason; Van Stijn, Caroline M W; Wu, Xiao-Hui; Lusis, Aldons J; Hong, Cynthia; Tangirala, Rajendra I; Tontonoz, Peter.

Circ Res ; 115(4): 442-9, 2014 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-24935961

6.

Dose-dependent targeted suppression of P-glycoprotein expression and function in Caco-2 cells.

Lee, Stephen D; Osei-Twum, Jo-Ann; Wasan, Kishor M.

Mol Pharm ; 10(6): 2323-30, 2013 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-23611024

7.

Evaluation of the contribution of the ATP binding cassette transporter, P-glycoprotein, to in vivo cholesterol homeostasis.

Lee, Stephen D; Thornton, Sheila J; Sachs-Barrable, Kristina; Kim, Jenny H; Wasan, Kishor M.

Mol Pharm ; 10(8): 3203-12, 2013 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-23750858

8.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake.

Ferrari, Alessandra; Whang, Emily; Xiao, Xu; Kennelly, John P; Romartinez-Alonso, Beatriz; Mack, Julia J; Weston, Thomas; Chen, Kai; Kim, Youngjae; Tol, Marcus J; Bideyan, Lara; Nguyen, Alexander; Gao, Yajing; Cui, Liujuan; Bedard, Alexander H; Sandhu, Jaspreet; Lee, Stephen D; Fairall, Louise; Williams, Kevin J; Song, Wenxin; Munguia, Priscilla; Russell, Robert A; Martin, Martin G; Jung, Michael E; Jiang, Haibo; Schwabe, John W R; Young, Stephen G; Tontonoz, Peter.

bioRxiv ; 2023 Jul 10.

Artigo em Inglês | MEDLINE | ID: mdl-37503112

9.

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.

Ferrari, Alessandra; Whang, Emily; Xiao, Xu; Kennelly, John P; Romartinez-Alonso, Beatriz; Mack, Julia J; Weston, Thomas; Chen, Kai; Kim, Youngjae; Tol, Marcus J; Bideyan, Lara; Nguyen, Alexander; Gao, Yajing; Cui, Liujuan; Bedard, Alexander H; Sandhu, Jaspreet; Lee, Stephen D; Fairall, Louise; Williams, Kevin J; Song, Wenxin; Munguia, Priscilla; Russell, Robert A; Martin, Martin G; Jung, Michael E; Jiang, Haibo; Schwabe, John W R; Young, Stephen G; Tontonoz, Peter.

Science ; 382(6671): eadf0966, 2023 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-37943936

10.

Inhibition of cholesterol absorption: targeting the intestine.

Lee, Stephen D; Gershkovich, Pavel; Darlington, Jerald W; Wasan, Kishor M.

Pharm Res ; 29(12): 3235-50, 2012 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-22923351

11.

NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.

Guo, Fangfei; Seldin, Marcus; Péterfy, Miklós; Charugundla, Sarada; Zhou, Zhiqiang; Lee, Stephen D; Mouton, Alice; Rajbhandari, Prashant; Zhang, Wenchao; Pellegrini, Matteo; Tontonoz, Peter; Lusis, Aldons J; Shih, Diana M.

Sci Rep ; 11(1): 16409, 2021 08 12.

Artigo em Inglês | MEDLINE | ID: mdl-34385484

12.

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes.

Rajbhandari, Prashant; Arneson, Douglas; Hart, Sydney K; Ahn, In Sook; Diamante, Graciel; Santos, Luis C; Zaghari, Nima; Feng, An-Chieh; Thomas, Brandon J; Vergnes, Laurent; Lee, Stephen D; Rajbhandari, Abha K; Reue, Karen; Smale, Stephen T; Yang, Xia; Tontonoz, Peter.

Elife ; 82019 10 23.

Artigo em Inglês | MEDLINE | ID: mdl-31644425

13.

IDOL regulates systemic energy balance through control of neuronal VLDLR expression.

Lee, Stephen D; Priest, Christina; Bjursell, Mikael; Gao, Jie; Arneson, Douglas V; Ahn, In Sook; Diamante, Graciel; van Veen, J Edward; Massa, Megan G; Calkin, Anna C; Kim, Jason; Andersén, Harriet; Rajbhandari, Prashant; Porritt, Michelle; Carreras, Alba; Ahnmark, Andrea; Seeliger, Frank; Maxvall, Ingela; Eliasson, Pernilla; Althage, Magnus; Åkerblad, Peter; Lindén, Daniel; Cole, Tracy A; Lee, Richard; Boyd, Helen; Bohlooly-Y, Mohammad; Correa, Stephanie M; Yang, Xia; Tontonoz, Peter; Hong, Cynthia.

Nat Metab ; 1(11): 1089-1100, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-32072135

14.

Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections.

Sachs-Barrable, Kristina; Lee, Stephen D; Wasan, Ellen K; Thornton, Sheila J; Wasan, Kishor M.

Adv Drug Deliv Rev ; 60(6): 692-701, 2008 Mar 17.

Artigo em Inglês | MEDLINE | ID: mdl-18053611

15.

Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism.

Thornton, Sheila J; Wong, Evelyn; Lee, Stephen D; Wasan, Kishor M.

Lipids Health Dis ; 7: 21, 2008 Jun 11.

Artigo em Inglês | MEDLINE | ID: mdl-18547429

16.

Prospective memory and subjective memory decline: A neuropsychological indicator of memory difficulties in community-dwelling older people.

Lee, Stephen D; Ong, Ben; Pike, Kerryn E; Kinsella, Glynda J.

J Clin Exp Neuropsychol ; 40(2): 183-197, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-28532271

17.

Mild cognitive impairment and prospective memory: translating the evidence into neuropsychological practice.

Kinsella, Glynda J; Pike, Kerryn E; Cavuoto, Marina G; Lee, Stephen D.

Clin Neuropsychol ; 32(5): 960-980, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29708011

18.

Long circulating lipid nanocapsules for drug detoxification.

Dhanikula, Anand Babu; Khalid, Nabil Mohamed; Lee, Stephen D; Yeung, Rosanna; Risovic, Verica; Wasan, Kishor M; Leroux, Jean-Christophe.

Biomaterials ; 28(6): 1248-57, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17125832

19.

Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells.

Sachs-Barrable, Kristina; Thamboo, Andrea; Lee, Stephen D; Wasan, Kishor M.

J Pharm Pharm Sci ; 10(3): 319-31, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17727795

20.

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Wang, Jiexin; Rajbhandari, Prashant; Damianov, Andrey; Han, Areum; Sallam, Tamer; Waki, Hironori; Villanueva, Claudio J; Lee, Stephen D; Nielsen, Ronni; Mandrup, Susanne; Reue, Karen; Young, Stephen G; Whitelegge, Julian; Saez, Enrique; Black, Douglas L; Tontonoz, Peter.

J Clin Invest ; 127(3): 987-1004, 2017 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-28192372

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