Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation.

Palmer, Amy L; de Jong, Annemieke; Leestemaker, Yves; Geurink, Paul P; Wijdeven, Ruud H; Ovaa, Huib; Dolan, Brian P.

J Immunol ; 200(3): 928-936, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29282303

2.

Tools to investigate the ubiquitin proteasome system.

Leestemaker, Yves; Ovaa, Huib.

Drug Discov Today Technol ; 26: 25-31, 2017 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-29249239

3.

Hitting the target.

Leestemaker, Yves; Ovaa, Huib.

Nat Methods ; 12(12): 1127-8, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26624797

4.

Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib.

Berkers, Celia R; Leestemaker, Yves; Schuurman, Karianne G; Ruggeri, Bruce; Jones-Bolin, Susan; Williams, Michael; Ovaa, Huib.

Mol Pharm ; 9(5): 1126-35, 2012 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-22432738

5.

Highlighting the Proteasome: Using Fluorescence to Visualize Proteasome Activity and Distribution.

Gan, Jin; Leestemaker, Yves; Sapmaz, Aysegul; Ovaa, Huib.

Front Mol Biosci ; 6: 14, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30968028

6.

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-ß in iPSC-Derived Alzheimer's Disease Neurons.

van der Kant, Rik; Langness, Vanessa F; Herrera, Cheryl M; Williams, Daniel A; Fong, Lauren K; Leestemaker, Yves; Steenvoorden, Evelyne; Rynearson, Kevin D; Brouwers, Jos F; Helms, J Bernd; Ovaa, Huib; Giera, Martin; Wagner, Steven L; Bang, Anne G; Goldstein, Lawrence S B.

Cell Stem Cell ; 24(3): 363-375.e9, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30686764

7.

Profiling the Activity of Deubiquitinating Enzymes Using Chemically Synthesized Ubiquitin-Based Probes.

Leestemaker, Yves; de Jong, Annemieke; Ovaa, Huib.

Methods Mol Biol ; 1491: 113-130, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-27778285

8.

Proteasome Activation by Small Molecules.

Leestemaker, Yves; de Jong, Annemieke; Witting, Katharina F; Penning, Renske; Schuurman, Karianne; Rodenko, Boris; Zaal, Esther A; van de Kooij, Bert; Laufer, Stefan; Heck, Albert J R; Borst, Jannie; Scheper, Wiep; Berkers, Celia R; Ovaa, Huib.

Cell Chem Biol ; 24(6): 725-736.e7, 2017 Jun 22.

Artigo em Inglês | MEDLINE | ID: mdl-28552582

9.

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

Widjaja, Christella E; Olvera, Jocelyn G; Metz, Patrick J; Phan, Anthony T; Savas, Jeffrey N; de Bruin, Gerjan; Leestemaker, Yves; Berkers, Celia R; de Jong, Annemieke; Florea, Bogdan I; Fisch, Kathleen; Lopez, Justine; Kim, Stephanie H; Garcia, Daniel A; Searles, Stephen; Bui, Jack D; Chang, Aaron N; Yates, John R; Goldrath, Ananda W; Overkleeft, Hermen S; Ovaa, Huib; Chang, John T.

J Clin Invest ; 127(10): 3609-3623, 2017 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-28846070

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