Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

α-Defensins in human innate immunity.

Lehrer, Robert I; Lu, Wuyuan.

Immunol Rev ; 245(1): 84-112, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22168415

2.

Hapivirins and diprovirins: novel Î¸-defensin analogs with potent activity against influenza A virus.

Doss, Mona; Ruchala, Piotr; Tecle, Tesfaldet; Gantz, Donald; Verma, Anamika; Hartshorn, Alex; Crouch, Erika C; Luong, Hai; Micewicz, Ewa D; Lehrer, Robert I; Hartshorn, Kevan L.

J Immunol ; 188(6): 2759-68, 2012 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-22345650

3.

Î¸-Defensins: cyclic peptides with endless potential.

Lehrer, Robert I; Cole, Alex M; Selsted, Michael E.

J Biol Chem ; 287(32): 27014-9, 2012 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-22700960

4.

Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.

Pazgier, Marzena; Wei, Gang; Ericksen, Bryan; Jung, Grace; Wu, Zhibin; de Leeuw, Erik; Yuan, Weirong; Szmacinski, Henryk; Lu, Wei-Yue; Lubkowski, Jacek; Lehrer, Robert I; Lu, Wuyuan.

J Biol Chem ; 287(12): 8944-53, 2012 Mar 16.

Artigo em Inglês | MEDLINE | ID: mdl-22270360

5.

Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes.

Arnett, Eusondia; Lehrer, Robert I; Pratikhya, Pratikhya; Lu, Wuyuan; Seveau, Stephanie.

Cell Microbiol ; 13(4): 635-51, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21143570

6.

Reawakening retrocyclins: ancestral human defensins active against HIV-1.

Venkataraman, Nitya; Cole, Amy L; Ruchala, Piotr; Waring, Alan J; Lehrer, Robert I; Stuchlik, Olga; Pohl, Jan; Cole, Alexander M.

PLoS Biol ; 7(4): e95, 2009 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-19402752

7.

Immunology: Peptide gets in shape for self-defence.

Lehrer, Robert I.

Nature ; 469(7330): 309-10, 2011 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-21248835

8.

Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners.

Rampersaud, Ryan; Planet, Paul J; Randis, Tara M; Kulkarni, Ritwij; Aguilar, Jorge L; Lehrer, Robert I; Ratner, Adam J.

J Bacteriol ; 193(5): 1034-41, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-21169489

9.

Trp-26 imparts functional versatility to human alpha-defensin HNP1.

Wei, Gang; Pazgier, Marzena; de Leeuw, Erik; Rajabi, Mohsen; Li, Jing; Zou, Guozhang; Jung, Grace; Yuan, Weirong; Lu, Wei-Yue; Lehrer, Robert I; Lu, Wuyuan.

J Biol Chem ; 285(21): 16275-85, 2010 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-20220136

10.

Multivalent binding of carbohydrates by the human alpha-defensin, HD5.

Lehrer, Robert I; Jung, Grace; Ruchala, Piotr; Andre, Sabine; Gabius, Hans J; Lu, Wuyuan.

J Immunol ; 183(1): 480-90, 2009 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-19542459

11.

Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Doss, Mona; White, Mitchell R; Tecle, Tesfaldet; Gantz, Donald; Crouch, Erika C; Jung, Grace; Ruchala, Piotr; Waring, Alan J; Lehrer, Robert I; Hartshorn, Kevan L.

J Immunol ; 182(12): 7878-87, 2009 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-19494312

12.

Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.

Mygind, Per H; Fischer, Rikke L; Schnorr, Kirk M; Hansen, Mogens T; Sönksen, Carsten P; Ludvigsen, Svend; Raventós, Dorotea; Buskov, Steen; Christensen, Bjarke; De Maria, Leonardo; Taboureau, Olivier; Yaver, Debbie; Elvig-Jørgensen, Signe G; Sørensen, Marianne V; Christensen, Bjørn E; Kjaerulff, Søren; Frimodt-Moller, Niels; Lehrer, Robert I; Zasloff, Michael; Kristensen, Hans-Henrik.

Nature ; 437(7061): 975-80, 2005 Oct 13.

Artigo em Inglês | MEDLINE | ID: mdl-16222292

13.

Induction of group A Streptococcus virulence by a human antimicrobial peptide.

Gryllos, Ioannis; Tran-Winkler, Hien J; Cheng, Ming-Fang; Chung, Hachung; Bolcome, Robert; Lu, Wuyuan; Lehrer, Robert I; Wessels, Michael R.

Proc Natl Acad Sci U S A ; 105(43): 16755-60, 2008 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-18936485

14.

Through the looking glass, mechanistic insights from enantiomeric human defensins.

Wei, Gang; de Leeuw, Erik; Pazgier, Marzena; Yuan, Weirong; Zou, Guozhang; Wang, Jianfeng; Ericksen, Bryan; Lu, Wei-Yue; Lehrer, Robert I; Lu, Wuyuan.

J Biol Chem ; 284(42): 29180-92, 2009 Oct 16.

Artigo em Inglês | MEDLINE | ID: mdl-19640840

15.

De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.

Stegemann, Christin; Tsvetkova, Elena V; Aleshina, Galina M; Lehrer, Robert I; Kokryakov, Vladimir N; Hoffmann, Ralf.

Rapid Commun Mass Spectrom ; 24(5): 599-604, 2010 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-20155756

16.

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Navab, Mohamad; Ruchala, Piotr; Waring, Alan J; Lehrer, Robert I; Hama, Susan; Hough, Greg; Palgunachari, Mayakonda N; Anantharamaiah, G M; Fogelman, Alan M.

J Lipid Res ; 50(8): 1538-47, 2009 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-19225094

17.

Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.

Lehrer, Robert I; Jung, Grace; Ruchala, Piotr; Wang, Wei; Micewicz, Ewa D; Waring, Alan J; Gillespie, Eugene J; Bradley, Kenneth A; Ratner, Adam J; Rest, Richard F; Lu, Wuyuan.

Infect Immun ; 77(9): 4028-40, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19581399

18.

Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: predicting experimental toxicity.

Langham, Allison A; Khandelia, Himanshu; Schuster, Benjamin; Waring, Alan J; Lehrer, Robert I; Kaznessis, Yiannis N.

Peptides ; 29(7): 1085-93, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18455267

19.

Insertion selectivity of antimicrobial peptide protegrin-1 into lipid monolayers: effect of head group electrostatics and tail group packing.

Ishitsuka, Yuji; Pham, Duy S; Waring, Alan J; Lehrer, Robert I; Lee, Ka Yee C.

Biochim Biophys Acta ; 1758(9): 1450-60, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-16989771

20.

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.

Fuhrman, Christopher A; Warren, Andrew D; Waring, Alan J; Dutz, Stephen M; Sharma, Shantanu; Lehrer, Robert I; Cole, Amy L; Cole, Alexander M.

FEBS J ; 274(24): 6477-87, 2007 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18028423

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