Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase.

Lei, Ruipeng; Kim, Wooseob; Lv, Huibin; Mou, Zongjun; Scherm, Michael J; Schmitz, Aaron J; Turner, Jackson S; Tan, Timothy J C; Wang, Yiquan; Ouyang, Wenhao O; Liang, Weiwen; Rivera-Cardona, Joel; Teo, Chuyun; Graham, Claire S; Brooke, Christopher B; Presti, Rachel M; Mok, Chris K P; Krammer, Florian; Dai, Xinghong; Ellebedy, Ali H; Wu, Nicholas C.

Immunity ; 56(11): 2621-2634.e6, 2023 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-37967533

2.

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike.

Tan, Timothy J C; Verma, Abhishek K; Odle, Abby; Lei, Ruipeng; Meyerholz, David K; Matreyek, Kenneth A; Perlman, Stanley; Wong, Lok-Yin Roy; Wu, Nicholas C.

Proc Natl Acad Sci U S A ; 121(15): e2317222121, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38557175

3.

Immunity certification for COVID-19: ethical considerations.

Voo, Teck Chuan; Reis, Andreas A; Thomé, Beatriz; Ho, Calvin Wl; Tam, Clarence C; Kelly-Cirino, Cassandra; Emanuel, Ezekiel; Beca, Juan P; Littler, Katherine; Smith, Maxwell J; Parker, Michael; Kass, Nancy; Gobat, Nina; Lei, Ruipeng; Upshur, Ross; Hurst, Samia; Munsaka, Sody.

Bull World Health Organ ; 99(2): 155-161, 2021 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-33551509

4.

Reboot ethics governance in China.

Lei, Ruipeng; Zhai, Xiaomei; Zhu, Wei; Qiu, Renzong.

Nature ; 569(7755): 184-186, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-31065097

5.

Ethical and regulatory issues in human gene editing: Chinese perspective.

Lei, Ruipeng; Qiu, Renzong.

Biotechnol Appl Biochem ; 67(6): 880-891, 2020 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-33011985

6.

Impassable scientific, ethical and legal barriers to body-to-head transplantation.

Lei, Ruipeng; Qiu, Renzong.

Bioethics ; 34(2): 172-182, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31639227

7.

Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety.

Wen, Zhiwei; Tuttle, Paloma R; Howlader, A Hasan; Vasilyeva, Anna; Gonzalez, Laura; Tangar, Antonija; Lei, Ruipeng; Laverde, Eduardo E; Liu, Yuan; Miksovska, Jaroslava; Wnuk, Stanislaw F.

J Org Chem ; 84(6): 3624-3631, 2019 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-30806513

8.

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning.

Lei, Ruipeng; Qing, Enya; Odle, Abby; Yuan, Meng; Gunawardene, Chaminda D; Tan, Timothy J C; So, Natalie; Ouyang, Wenhao O; Wilson, Ian A; Gallagher, Tom; Perlman, Stanley; Wu, Nicholas C; Wong, Lok-Yin Roy.

Nat Commun ; 15(1): 4056, 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38744813

9.

Analysis of ethics dumping and proposed solutions in the field of biomedical research in China.

Liao, Bohua; Ma, Yonghui; Lei, Ruipeng.

Front Pharmacol ; 14: 1214590, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37701030

10.

A leap of faith: building the trust in human biobanks.

Zhang, Yi; Liao, Bohua; Lei, Ruipeng.

Front Genet ; 14: 1261623, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37928244

11.

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem.

Teo, Qi Wen; Wang, Yiquan; Lv, Huibin; Tan, Timothy J C; Lei, Ruipeng; Mao, Kevin J; Wu, Nicholas C.

Cell Rep ; 42(11): 113410, 2023 11 28.

Artigo em Inglês | MEDLINE | ID: mdl-37976161

12.

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem.

Teo, Qi Wen; Wang, Yiquan; Lv, Huibin; Tan, Timothy J C; Lei, Ruipeng; Mao, Kevin J; Wu, Nicholas C.

bioRxiv ; 2023 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-37461670

13.

Mutational fitness landscape of human influenza H3N2 neuraminidase.

Lei, Ruipeng; Hernandez Garcia, Andrea; Tan, Timothy J C; Teo, Qi Wen; Wang, Yiquan; Zhang, Xiwen; Luo, Shitong; Nair, Satish K; Peng, Jian; Wu, Nicholas C.

Cell Rep ; 42(1): 111951, 2023 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-36640354

14.

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike.

Tan, Timothy J C; Mou, Zongjun; Lei, Ruipeng; Ouyang, Wenhao O; Yuan, Meng; Song, Ge; Andrabi, Raiees; Wilson, Ian A; Kieffer, Collin; Dai, Xinghong; Matreyek, Kenneth A; Wu, Nicholas C.

Nat Commun ; 14(1): 2003, 2023 04 10.

Artigo em Inglês | MEDLINE | ID: mdl-37037866

15.

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning.

Lei, Ruipeng; Qing, Enya; Odle, Abby; Yuan, Meng; Tan, Timothy J C; So, Natalie; Ouyang, Wenhao O; Wilson, Ian A; Gallagher, Tom; Perlman, Stanley; Wu, Nicholas C; Wong, Lok-Yin Roy.

bioRxiv ; 2023 Nov 29.

Artigo em Inglês | MEDLINE | ID: mdl-38076875

16.

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies.

Wang, Yiquan; Lv, Huibin; Lei, Ruipeng; Yeung, Yuen-Hei; Shen, Ivana R; Choi, Danbi; Teo, Qi Wen; Tan, Timothy J C; Gopal, Akshita B; Chen, Xin; Graham, Claire S; Wu, Nicholas C.

bioRxiv ; 2023 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-37745338

17.

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses.

Daulagala, Pavithra; Mann, Brian R; Leung, Kathy; Lau, Eric H Y; Yung, Louise; Lei, Ruipeng; Nizami, Sarea I N; Wu, Joseph T; Chiu, Susan S; Daniels, Rodney S; Wu, Nicholas C; Wentworth, David; Peiris, Malik; Yen, Hui-Ling.

mBio ; 14(3): e0008423, 2023 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-37070986

18.

Regulation and management of the biosecurity for synthetic biology.

Zeng, Xiaomei; Jiang, Hailun; Yang, Guangying; Ou, Yakun; Lu, Shan; Jiang, Jia; Lei, Ruipeng; Su, Li.

Synth Syst Biotechnol ; 7(2): 784-790, 2022 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-35387231

19.

Globin X: A highly stable intrinsically hexacoordinate globin.

Farhana, Rifat; Lei, Ruipeng; Pham, Khoa; Derrien, Valerie; Cedeño, Jonathan; Rodriquez, Veronica; Bernad, Sophie; Lima, Francisco Fernandez; Miksovska, Jaroslava.

J Inorg Biochem ; 236: 111976, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36058051

20.

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning.

Ouyang, Wenhao O; Tan, Timothy J C; Lei, Ruipeng; Song, Ge; Kieffer, Collin; Andrabi, Raiees; Matreyek, Kenneth A; Wu, Nicholas C.

Sci Adv ; 8(47): eadd7221, 2022 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-36417523

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Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase.

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike.

Immunity certification for COVID-19: ethical considerations.

Reboot ethics governance in China.

Ethical and regulatory issues in human gene editing: Chinese perspective.

Impassable scientific, ethical and legal barriers to body-to-head transplantation.

Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety.

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning.

Analysis of ethics dumping and proposed solutions in the field of biomedical research in China.

A leap of faith: building the trust in human biobanks.

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem.

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem.

Mutational fitness landscape of human influenza H3N2 neuraminidase.

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike.

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning.

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies.

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses.

Regulation and management of the biosecurity for synthetic biology.

Globin X: A highly stable intrinsically hexacoordinate globin.

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning.