Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Deletion of protein kinase CÎµ in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis.

Raddatz, K; Frangioudakis, G; Diakanastasis, B; Liao, B M; Leitges, M; Schmitz-Peiffer, C.

Diabetologia ; 55(10): 2789-2793, 2012 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-22814763

2.

Deletion of protein kinase CÎ´ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

Cantley, J; Boslem, E; Laybutt, D R; Cordery, D V; Pearson, G; Carpenter, L; Leitges, M; Biden, T J.

Diabetologia ; 54(2): 380-9, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21103982

3.

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

Raddatz, K; Turner, N; Frangioudakis, G; Liao, B M; Pedersen, D J; Cantley, J; Wilks, D; Preston, E; Hegarty, B D; Leitges, M; Raftery, M J; Biden, T J; Schmitz-Peiffer, C.

Diabetologia ; 54(6): 1447-56, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21347625

4.

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

Sajan, M P; Bandyopadhyay, G; Miura, A; Standaert, M L; Nimal, S; Longnus, S L; Van Obberghen, E; Hainault, I; Foufelle, F; Kahn, R; Braun, U; Leitges, M; Farese, R V.

Am J Physiol Endocrinol Metab ; 298(2): E179-92, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19887597

5.

The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

Chan, V W; Mecklenbräuker, I; Su, I; Texido, G; Leitges, M; Carsetti, R; Lowell, C A; Rajewsky, K; Miyake, K; Tarakhovsky, A.

J Exp Med ; 188(1): 93-101, 1998 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-9653087

6.

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

Frangioudakis, G; Burchfield, J G; Narasimhan, S; Cooney, G J; Leitges, M; Biden, T J; Schmitz-Peiffer, C.

Diabetologia ; 52(12): 2616-20, 2009 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-19809797

7.

Immunodeficiency in protein kinase cbeta-deficient mice.

Leitges, M; Schmedt, C; Guinamard, R; Davoust, J; Schaal, S; Stabel, S; Tarakhovsky, A.

Science ; 273(5276): 788-91, 1996 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-8670417

8.

Protein kinase C-delta (PKCÎ´), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar, S P; Ozturk, M; Marakalala, M J; Loots, D T; Hurdayal, R; Maasdorp, D Beukes; Van Reenen, M; Zak, D E; Darboe, F; Penn-Nicholson, A; Hanekom, W A; Leitges, M; Scriba, T J; Guler, R; Brombacher, F.

Mucosal Immunol ; 11(2): 496-511, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-28832027

9.

Protein kinase C-delta (PKCÎ´), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar, S P; Ozturk, M; Marakalala, M J; Loots, D T; Hurdayal, R; Beukes, D; Van Reenen, M; Zak, D E; Mbandi, S K; Darboe, F; Penn-Nicholson, A; Hanekom, W A; Leitges, M; Scriba, T J; Guler, R; Brombacher, F.

Mucosal Immunol ; 11(2): 579-580, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29346346

10.

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice.

Leitges, M; Mayr, M; Braun, U; Mayr, U; Li, C; Pfister, G; Ghaffari-Tabrizi, N; Baier, G; Hu, Y; Xu, Q.

J Clin Invest ; 108(10): 1505-12, 2001 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-11714742

11.

Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.

Standaert, M L; Bandyopadhyay, G; Galloway, L; Soto, J; Ono, Y; Kikkawa, U; Farese, R V; Leitges, M.

Endocrinology ; 140(10): 4470-7, 1999 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-10499500

12.

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFß signaling axis.

Hill, K S; Erdogan, E; Khoor, A; Walsh, M P; Leitges, M; Murray, N R; Fields, A P.

Oncogene ; 33(16): 2134-44, 2014 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-23604119

13.

Functional PKC in vivo analysis using deficient mouse models.

Leitges, M.

Biochem Soc Trans ; 35(Pt 5): 1018-20, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17956267

14.

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.

Menne, J; Meier, M; Park, J-K; Boehne, M; Kirsch, T; Lindschau, C; Ociepka, R; Leitges, M; Rinta-Valkama, J; Holthofer, H; Haller, H.

Kidney Int ; 70(8): 1456-62, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16955103

15.

Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells.

Leitges, M; Elis, W; Gimborn, K; Huber, M.

Lab Invest ; 81(8): 1087-95, 2001 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-11502860

16.

Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta.

Nechushtan, H; Leitges, M; Cohen, C; Kay, G; Razin, E.

Blood ; 95(5): 1752-7, 2000 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-10688834

17.

The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column.

Leitges, M; Neidhardt, L; Haenig, B; Herrmann, B G; Kispert, A.

Development ; 127(11): 2259-67, 2000 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-10804169

18.

PKC-beta is not necessary for cardiac hypertrophy.

Roman, B B; Geenen, D L; Leitges, M; Buttrick, P M.

Am J Physiol Heart Circ Physiol ; 280(5): H2264-70, 2001 May.

Artigo em Inglês | MEDLINE | ID: mdl-11299230

19.

Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils.

Dekker, L V; Leitges, M; Altschuler, G; Mistry, N; McDermott, A; Roes, J; Segal, A W.

Biochem J ; 347 Pt 1: 285-9, 2000 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-10727429

20.

A role for the beta isoform of protein kinase C in fear conditioning.

Weeber, E J; Atkins, C M; Selcher, J C; Varga, A W; Mirnikjoo, B; Paylor, R; Leitges, M; Sweatt, J D.

J Neurosci ; 20(16): 5906-14, 2000 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-10934237

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Deletion of protein kinase CÎµ in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis.

Deletion of protein kinase CÎ´ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

Immunodeficiency in protein kinase cbeta-deficient mice.

Protein kinase C-delta (PKCÎ´), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Protein kinase C-delta (PKCÎ´), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice.

Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFß signaling axis.

Functional PKC in vivo analysis using deficient mouse models.

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.

Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells.

Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta.

The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column.

PKC-beta is not necessary for cardiac hypertrophy.

Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils.

A role for the beta isoform of protein kinase C in fear conditioning.