Detalhe da pesquisa
1.
The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.
Molecules
; 24(13)2019 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31324042
2.
FAK dimerization controls its kinase-dependent functions at focal adhesions.
EMBO J
; 33(4): 356-70, 2014 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24480479
3.
SF2312 is a natural phosphonate inhibitor of enolase.
Nat Chem Biol
; 12(12): 1053-1058, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27723749
4.
A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.
Nucleic Acids Res
; 43(9): 4758-73, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25897118
5.
The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding.
Angew Chem Int Ed Engl
; 56(41): 12590-12593, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28833982
6.
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem J
; 466(2): 337-46, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25486442
7.
Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation.
Proc Natl Acad Sci U S A
; 110(21): 8525-30, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650349
8.
Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.
Proc Natl Acad Sci U S A
; 108(33): 13468-73, 2011 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21808041
9.
Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.
J Biol Chem
; 287(20): 16541-9, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22427660
10.
H-NS forms a superhelical protein scaffold for DNA condensation.
Proc Natl Acad Sci U S A
; 107(36): 15728-32, 2010 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20798056
11.
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
Science
; 379(6636): 996-1003, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893255
12.
Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding.
Biochemistry
; 51(50): 10035-43, 2012 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23181972
13.
Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.
J Med Chem
; 65(3): 2388-2408, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34982556
14.
GRB2 enforces homology-directed repair initiation by MRE11.
Sci Adv
; 7(32)2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348893
15.
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J Med Chem
; 64(20): 15141-15169, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34643390
16.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292726
17.
Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.
Mol Microbiol
; 73(2): 165-79, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19508284
18.
The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 4): 421-5, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20383013
19.
Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.
J Med Chem
; 63(10): 5242-5256, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255647
20.
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
J Med Chem
; 63(17): 9888-9911, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787110