Detalhe da pesquisa
1.
The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.
Br J Clin Pharmacol
; 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38690606
2.
The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.
J Biol Chem
; 295(33): 11754-11763, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32587091
3.
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Bioorg Med Chem Lett
; 26(23): 5741-5748, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810243
4.
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Bioorg Med Chem Lett
; 25(12): 2496-500, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978964
5.
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.
Bioorg Med Chem Lett
; 24(11): 2571-7, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755427
6.
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Bioorg Med Chem Lett
; 24(5): 1315-21, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24508129
7.
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
J Med Chem
; 66(19): 13400-13415, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37738648
8.
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J Med Chem
; 64(18): 13807-13829, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34464130
9.
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.
ACS Med Chem Lett
; 10(6): 972-977, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223457
10.
Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.
Biomol NMR Assign
; 12(2): 263-268, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29667121
11.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J Med Chem
; 61(5): 1785-1799, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29424542
12.
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.
J Med Chem
; 61(17): 7796-7813, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30095900
13.
Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.
ACS Med Chem Lett
; 8(6): 672-677, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626531
14.
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J Med Chem
; 60(20): 8591-8605, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28937774
15.
Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.
Proteins
; 63(3): 424-39, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16470849
16.
Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure
; 23(12): 2280-2290, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26602186
17.
Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic Acid bioisostere.
ACS Med Chem Lett
; 3(7): 574-8, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900513